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The Journal of Immunology, Vol 157, Issue 10 4273-4276, Copyright © 1996 by American Association of Immunologists
CUTTING EDGE |
RE Langman and M Cohn
The Salk Institute, San Diego, CA 92186, USA.
The danger model differs from the associative recognition model solely with respect to the origin of effector T helpers (eTh). More properly, the danger model should be juxtaposed to the Ag-independent model for the origin of eTh cells (i.e., the primer question). The introduction of danger in no way challenges the need to make a self-nonself discrimination, nor, for that matter, does it challenge the need to define self as those Ags encountered in the absence of eTh and that persist, whereas nonself are those Ags encountered in the presence of eTh and that are transient. The clarification of these points is our goal here.
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  R. E. Langman, J. J. Mata, and M. Cohn A computerized model for the self-non-self discrimination at the level of the Th (Th genesis). II. The behavior of the system upon encounter with non-self antigens Int. Immunol., May 1, 2003; 15(5): 593 - 609. [Abstract] [Full Text] [PDF]
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 C. C. Anderson, J. M. Carroll, S. Gallucci, J. P. Ridge, A. W. Cheever, and P. Matzinger Testing Time-, Ignorance-, and Danger-Based Models of Tolerance J. Immunol., March 15, 2001; 166(6): 3663 - 3671. [Abstract] [Full Text] [PDF]
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R. E. Langman and M. Cohn Away with words: commentary on the Atlan–Cohen essay `Immune information, self-organization and meaning' Int. Immunol., June 1, 1999; 11(6): 865 - 870. [Abstract] [Full Text] [PDF]
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