| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 157, Issue 1 65-71, Copyright © 1996 by American Association of Immunologists
ARTICLES |
CF Rubio, J Kench, DM Russell, R Yawger and D Nemazee
Division of Basic Science, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.
The effect of the autoimmune prone MRL/lpr (H-2k) genetic background on central B cell tolerance was studied in mice bearing 3-83 (anti-H-2Kk) Ig heavy and light chain transgenes. B cells bearing the dominant, transgene-encoded anti-H-2Kk specificity were tolerized appropriately on the MRL/lpr genetic background. Nevertheless, mice developed disease traits characteristic of the MRL/lpr strain, including lymphadenopathy and elevated levels of IgG dsDNA autoantibodies. Two transgenic lines were examined in this analysis: 3-83 mu delta, which expresses IgM and IgD forms of the 3-83 Ab, and Tol 1, which expresses only the IgM form of 3-83. The results obtained differed somewhat between the two transgenic lines. Crosses using 3-83 mu(delta) mice never demonstrated any defects in B cell self-tolerance to H-2Kk. Similarly, no Kk autoantibody production was seen in Tol 1 mice that were backcrossed onto the MRL/lpr genetic background and maintained in a specific pathogen-free facility. However, a subset of Tol 1/MRL/lpr mice that were housed in a conventional mouse facility demonstrated significant transgene-derived anti-Kk autoantibodies. Overall, these results suggest that there is no general defect in central B cell tolerance in MRL/lpr mice, despite their defect in the fas gene. These findings suggest similarities between the MRL/lpr T and B cell systems, because both fail to manifest clear central tolerance defects, but they nevertheless promote hyperplasia and autoimmunity in the peripheral immune system.
This article has been cited by other articles:
|
|
 |
|
  H.-Y. Lee, Y.-K. Hong, H.-J. Yun, Y.-M. Kim, J.-R. Kim, and W.-H. Yoo Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus Rheumatology, June 1, 2008; 47(6): 789 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Lamoureux, L. C. Watson, M. Cherrier, P. Skog, D. Nemazee, and A. J. Feeney Reduced receptor editing in lupus-prone MRL/lpr mice J. Exp. Med., November 26, 2007; 204(12): 2853 - 2864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nijnik, H. Ferry, G. Lewis, E. Rapsomaniki, J. C. H. Leung, A. Daser, T. Lambe, C. C. Goodnow, and R. J. Cornall Spontaneous B cell hyperactivity in autoimmune-prone MRL mice Int. Immunol., July 1, 2006; 18(7): 1127 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Kumar, L. Li, M. Yan, M. Bhaskarabhatla, A. B. Mobley, C. Nguyen, J. M. Mooney, J. D. Schatzle, E. K. Wakeland, and C. Mohan Regulation of B cell tolerance by the lupus susceptibility gene ly108. Science, June 16, 2006; 312(5780): 1665 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chen, H. Li, Q. Tian, M. Beardall, Y. Xu, N. Casanova, and M. Weigert Selection of Anti-Double-Stranded DNA B Cells in Autoimmune MRL-lpr/lpr Mice J. Immunol., May 1, 2006; 176(9): 5183 - 5190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. William, C. Euler, E. Leadbetter, A. Marshak-Rothstein, and M. J. Shlomchik Visualizing the Onset and Evolution of an Autoantibody Response in Systemic Autoimmunity J. Immunol., June 1, 2005; 174(11): 6872 - 6878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hayashi, T. Nojima, R. Goitsuka, and D. Kitamura Impaired Receptor Editing in the Primary B Cell Repertoire of BASH-Deficient Mice J. Immunol., November 15, 2004; 173(10): 5980 - 5988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Enders, P. Bouillet, H. Puthalakath, Y. Xu, D. M. Tarlinton, and A. Strasser Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation-induced Apoptosis and Deletion of Autoreactive B Cells J. Exp. Med., October 6, 2003; 198(7): 1119 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Seagal, N. Leider, G. Wildbaum, N. Karin, and D. Melamed Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Ig{micro}-deficient/lpr mice Int. Immunol., September 1, 2003; 15(9): 1045 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. SHLOMCHIK, C. W. EULER, S. C. CHRISTENSEN, and J. WILLIAM Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune-Prone MRL/lpr Mice Ann. N.Y. Acad. Sci., April 1, 2003; 987(1): 38 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, H. Li, D. Ni, and M. Weigert Anti-DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern J. Exp. Med., December 16, 2002; 196(12): 1543 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Rudolph, K. L. Congdon, F. N. A. Sackey, M. M. Fitzsimons, and M. H. Foster Humoral Autoimmunity to Basement Membrane Antigens Is Regulated in C57BL/6 and MRL/MpJ Mice Transgenic for Anti-Laminin Ig Receptors J. Immunol., June 1, 2002; 168(11): 5943 - 5953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Borrero and S. H. Clarke Low-Affinity Anti-Smith Antigen B Cells Are Regulated by Anergy as Opposed to Developmental Arrest or Differentiation to B-1 J. Immunol., January 1, 2002; 168(1): 13 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Cocca, S. N. Seal, P. D'Agnillo, Y. M. Mueller, P. D. Katsikis, J. Rauch, M. Weigert, and M. Z. Radic Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells PNAS, November 20, 2001; 98(24): 13826 - 13831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, N. Takahashi, H. Kakinuma, and Y. Nishi Molecular Evolution of Catalytic Antibodies in Autoimmune Mice J. Immunol., November 15, 2001; 167(10): 5775 - 5785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Tian, C.-H. G. Chou, and A. L. DeFranco Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells Int. Immunol., April 1, 2001; 13(4): 581 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, D. S. Smith, A. Guth, and L. J. Wysocki A Receptor Presentation Hypothesis for T Cell Help That Recruits Autoreactive B Cells J. Immunol., February 1, 2001; 166(3): 1562 - 1571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang and M. J. Shlomchik Autoantigen-specific B Cell Activation in Fas-deficient Rheumatoid Factor Immunoglobulin Transgenic Mice J. Exp. Med., September 6, 1999; 190(5): 639 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Brard, M. Shannon, E. L. Prak, S. Litwin, and M. Weigert Somatic Mutation and Light Chain Rearrangement Generate Autoimmunity in Anti–single-stranded DNA Transgenic MRL/lpr Mice J. Exp. Med., September 6, 1999; 190(5): 691 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mandik-Nayak, S.-j. Seo, C. Sokol, K. M. Potts, A. Bui, and J. Erikson MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti-double-stranded DNA B Cells J. Exp. Med., June 7, 1999; 189(11): 1799 - 1814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. T.M. Chan, L. G. Hannum, A. M. Haberman, M. P. Madaio, and M. J. Shlomchik A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus J. Exp. Med., May 17, 1999; 189(10): 1639 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Friedmann, N. Yachimovich, G. Mostoslavsky, Y. Pewzner-Jung, A. Ben-Yehuda, K. Rajewsky, and D. Eilat Production of High Affinity Autoantibodies in Autoimmune New Zealand Black/New Zealand White F1 Mice Targeted with an Anti-DNA Heavy Chain J. Immunol., April 15, 1999; 162(8): 4406 - 4416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Kench, D. M. Russell, and D. Nemazee Efficient Peripheral Clonal Elimination of B Lymphocytes in MRL/lpr Mice Bearing Autoantibody Transgenes J. Exp. Med., September 7, 1998; 188(5): 909 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Spatz, V. Saenko, A. Iliev, L. Jones, L. Geskin, and B. Diamond Light Chain Usage in Anti-double-stranded DNA B Cell Subsets: Role in Cell Fate Determination J. Exp. Med., April 7, 1997; 185(7): 1317 - 1326. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
