The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fikrig, E
Right arrow Articles by Flavell, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fikrig, E
Right arrow Articles by Flavell, R.

The Journal of Immunology, Vol 157, Issue 1 1-3, Copyright © 1996 by American Association of Immunologists

CUTTING EDGE

Protective antibodies in murine Lyme disease arise independently of CD40 ligand

E Fikrig, SW Barthold, M Chen, IS Grewal, J Craft and RA Flavell
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Borrelia burgdorferi-infected mice develop acute arthritis that undergoes Ab-mediated resolution. To further investigate the role of B. burgdorferi-specific Abs in Lyme borreliosis, CD40 ligand-deficient (CD40L-deficient) mice were infected with B. burgdorferi. The development and regression of arthritis were similar in CD40L-deficient and control mice. Although CD40L-deficient mice have defects in Ig class switching, infected CD40L-deficient mice developed B. burgdorferi- specific IgG2b Abs. Moreover, the transfer of serum from B. burgdorferi- infected CD40L-deficient animals prevented infection in severe combined immunodeficient mice. These data show that B. burgdorferi-infected CD40L-deficient mice are capable of producing Abs that are protective, despite the inability of these mice to mediate T-dependent immune responses.


This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
U. Pal, P. Wang, F. Bao, X. Yang, S. Samanta, R. Schoen, G. P. Wormser, I. Schwartz, and E. Fikrig
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis
J. Exp. Med., January 21, 2008; 205(1): 133 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. R. Alugupalli, S. Akira, E. Lien, and J. M. Leong
MyD88- and Bruton's Tyrosine Kinase-Mediated Signals Are Essential for T Cell-Independent Pathogen-Specific IgM Responses
J. Immunol., March 15, 2007; 178(6): 3740 - 3749.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Guerau-de-Arellano, J. Alroy, and B. T. Huber
{beta}2 Integrins Control the Severity of Murine Lyme Carditis
Infect. Immun., June 1, 2005; 73(6): 3242 - 3250.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. A. Belperron, C. M. Dailey, and L. K. Bockenstedt
Infection-Induced Marginal Zone B Cell Production of Borrelia hermsii-Specific Antibody Is Impaired in the Absence of CD1d
J. Immunol., May 1, 2005; 174(9): 5681 - 5686.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. O. Willer and S. H. Speck
Establishment and Maintenance of Long-Term Murine Gammaherpesvirus 68 Latency in B Cells in the Absence of CD40
J. Virol., March 1, 2005; 79(5): 2891 - 2899.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
E. S. Raveche, S. E. Schutzer, H. Fernandes, H. Bateman, B. A. McCarthy, S. P. Nickell, and M. W. Cunningham
Evidence of Borrelia Autoimmunity-Induced Component of Lyme Carditis and Arthritis
J. Clin. Microbiol., February 1, 2005; 43(2): 850 - 856.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. K. Bockenstedt, M.-C. Shanafelt, A. Belperron, J. Mao, and S. W. Barthold
Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected {gamma}{delta} T-Cell-Deficient Mice
Infect. Immun., May 1, 2003; 71(5): 2938 - 2940.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Anguita, S. W. Barthold, R. Persinski, M. N. Hedrick, C. A. Huy, R. J. Davis, R. A. Flavell, and E. Fikrig
Murine Lyme Arthritis Development Mediated by p38 Mitogen-Activated Protein Kinase Activity
J. Immunol., June 15, 2002; 168(12): 6352 - 6357.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Thomas, J. Anguita, S. W. Barthold, and E. Fikrig
Coinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis
Infect. Immun., May 1, 2001; 69(5): 3359 - 3371.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. L. Mbow, N. Zeidner, R. D. Gilmore Jr., M. Dolan, J. Piesman, and R. G. Titus
Major Histocompatibility Complex Class II-Independent Generation of Neutralizing Antibodies against T-Cell-Dependent Borrelia burgdorferi Antigens Presented by Dendritic Cells: Regulation by NK and {gamma}{delta} T Cells
Infect. Immun., April 1, 2001; 69(4): 2407 - 2415.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Kumar, A. Belperron, S. W. Barthold, and L. K. Bockenstedt
Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi
J. Immunol., November 1, 2000; 165(9): 4797 - 4801.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. D. McKisic and S. W. Barthold
T-Cell-Independent Responses to Borrelia burgdorferi Are Critical for Protective Immunity and Resolution of Lyme Disease
Infect. Immun., September 1, 2000; 68(9): 5190 - 5197.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. D. McKisic, W. L. Redmond, and S. W. Barthold
Cutting Edge: T Cell-Mediated Pathology in Murine Lyme Borreliosis
J. Immunol., June 15, 2000; 164(12): 6096 - 6099.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Szomolanyi-Tsuda, J. D. Brien, J. E. Dorgan, R. M. Welsh, and R. L. Garcea
The Role of CD40-CD154 Interaction in Antiviral T Cell-Independent IgG Responses
J. Immunol., June 1, 2000; 164(11): 5877 - 5882.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y.-i. Hwang, M. H. Nahm, D. E. Briles, D. Thomas, and J. M. Purkerson
Acquired, but Not Innate, Immune Responses to Streptococcus pneumoniae Are Compromised by Neutralization of CD40L
Infect. Immun., February 1, 2000; 68(2): 511 - 517.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. Andersen, T. Jensen, A. Nansen, O. Marker, and A. R. Thomsen
CD4+ T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-{gamma} or IL-4
Int. Immunol., December 1, 1999; 11(12): 2035 - 2042.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. Ozaki, B. A. Coren, T. N. Huynh, D. J. Redondo, H. Kikutani, and S. R. Webb
CD4+ T Cell Responses to CD40-Deficient APCs: Defects in Proliferation and Negative Selection Apply Only with B Cells as APCs
J. Immunol., November 15, 1999; 163(10): 5250 - 5256.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Chaussabel, F. Jacobs, J. de Jonge, M. de Veerman, Y. Carlier, K. Thielemans, M. Goldman, and B. Vray
CD40 Ligation Prevents Trypanosoma cruzi Infection through Interleukin-12 Upregulation
Infect. Immun., April 1, 1999; 67(4): 1929 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. J. Mathiesen, A. Holm, M. Christiansen, J. Blom, K. Hansen, S. Ostergaard, and M. Theisen
The Dominant Epitope of Borrelia garinii Outer Surface Protein C Recognized by Sera from Patients with Neuroborreliosis Has a Surface-Exposed Conserved Structural Motif
Infect. Immun., September 1, 1998; 66(9): 4073 - 4079.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. P. Seiler, Y. Ma, J. H. Weis, P. S. Frenette, R. O. Hynes, D. D. Wagner, and J. J. Weis
E and P Selectins Are Not Required for Resistance to Severe Murine Lyme Arthritis
Infect. Immun., September 1, 1998; 66(9): 4557 - 4559.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. R. Pachner, K. Amemiya, E. Delaney, T. O'Neill, C. A. N. Hughes, and W.-F. Zhang
Interleukin-6 is expressed at high levels in the CNS in Lyme neuroborreliosis
Neurology, July 1, 1997; 49(1): 147 - 152.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.