| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 156, Issue 9 3550-3557, Copyright © 1996 by American Association of Immunologists
ARTICLES |
T Murohara, JA Delyani, SM Albelda and AM Lefer
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Polymorphonuclear leukocytes have been shown to play an important role in myocardial ischemia (MI) and reperfusion (R) injury. Since blockade of platelet-endothelial cell adhesion molecules (PECAM-1) inhibits neutrophil transmigration in vitro and in vivo, the effects of a polygonal Ab directed against PECAM-1 were examined in a feline model of Ml/R. We established cross-reactivity of our anti-human PECAM-1 Ab to cat coronary vasculature and neutrophils by immunohistochemistry and flow cytometry. The anti-PECAM-1 Ab markedly blocked leukocyte transmigration into the peritoneal cavity of cats after glycogen- induced peritonitis. Then, anti-PECAM-1 Ab (1 mg/kg) was tested to determine whether it attenuates MI/R injury in a well characterized feline model of Ml and R. Anti-PECAM-1 Ab administered 10 min before R significantly inhibited the myocardial necrosis seen 4.5 h post-R compared with that in MI/R cats treated with control isotype rabbit IgG (12 +/- 2 vs 29 +/- 4% of area at risk; p less than 0.01) and significantly attenuated the rise in plasma creatine kinase activity (p less than 0.05). The Ab did not prevent increases in cardiac myeloperoxidase activity within the affected regions and did not significantly inhibit autologous neutrophil adhesion to coronary endothelium after stimulation of either neutrophils (by leukotriene B4) or coronary endothelium (by thrombin) in vitro. These results indicate that in vivo blockade of PECAM-1 significantly attenuates MI/R injury, presumably by inhibiting transendothelial migration of neutrophils.
This article has been cited by other articles:
|
|
 |
|
  A. Ramachandran, S. Jha, and D. J. Lefer REVIEW Paper: Pathophysiology of Myocardial Reperfusion Injury: The Role of Genetically Engineered Mouse Models Vet. Pathol., September 1, 2008; 45(5): 698 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Woodfin, M.-B. Voisin, and S. Nourshargh PECAM-1: A Multi-Functional Molecule in Inflammation and Vascular Biology Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2514 - 2523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Lou, P. Alcaide, F. W. Luscinskas, and W. A. Muller CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils J. Immunol., January 15, 2007; 178(2): 1136 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Albelda, K. C. Lau, P. Chien, Z.-Y. Huang, E. Arguiris, A. Bohen, J. Sun, J. A. Billet, M. Christofidou-Solomidou, Z. K. Indik, et al. Role for Platelet-Endothelial Cell Adhesion Molecule-1 in Macrophage Fc{gamma} Receptor Function Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2): 246 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. van Buul and P. L. Hordijk Signaling in Leukocyte Transendothelial Migration Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 824 - 833. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Feng, J. A. Nagy, K. Pyne, H. F. Dvorak, and A. M. Dvorak Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium J. Histochem. Cytochem., January 1, 2004; 52(1): 87 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. O'Brien, P. Lim, J. Sun, and S. M. Albelda PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization Blood, April 1, 2003; 101(7): 2816 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tasaka, L. Qin, A. Saijo, S. M. Albelda, H. M. DeLisser, and C. M. Doerschuk Platelet Endothelial Cell Adhesion Molecule-1 in Neutrophil Emigration during Acute Bacterial Pneumonia in Mice and Rats Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 164 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-D. Wang, J. Pernow, P.-O. Sjoquist, and L. Ryden Pharmacological possibilities for protection against myocardial reperfusion injury Cardiovasc Res, July 1, 2002; 55(1): 25 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wiewrodt, A. P. Thomas, L. Cipelletti, M. Christofidou-Solomidou, D. A. Weitz, S. I. Feinstein, D. Schaffer, S. M. Albelda, M. Koval, and V. R. Muzykantov Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells Blood, February 1, 2002; 99(3): 912 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Pernow, A.T. Gonon, and A. Gourine The role of the endothelium for reperfusion injury Eur. Heart J. Suppl., June 1, 2001; 3(suppl_C): C22 - C27. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Shintani, T. Murohara, H. Ikeda, T. Ueno, K.-i. Sasaki, J. Duan, and T. Imaizumi Augmentation of Postnatal Neovascularization With Autologous Bone Marrow Transplantation Circulation, February 13, 2001; 103(6): 897 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Nakada, K. Amin, M. Christofidou-Solomidou, C. D. O'Brien, J. Sun, I. Gurubhagavatula, G. A. Heavner, A. H. Taylor, C. Paddock, Q.-H. Sun, et al. Antibodies Against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block In Vivo Neutrophil Recruitment J. Immunol., January 1, 2000; 164(1): 452 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liao, A. R. Schenkel, and W. A. Muller Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes J. Immunol., November 15, 1999; 163(10): 5640 - 5648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Lefer Role of the {beta}2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion Ann. Thorac. Surg., November 1, 1999; 68(5): 1920 - 1923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Quarmby, P. Kumar, J. Wang, J. A. Macro, J. J. Hutchinson, R. D. Hunter, and S. Kumar Irradiation Induces Upregulation of CD31 in Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 588 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Duncan, D. P. Andrew, H. Takimoto, S. A. Kaufman, H. Yoshida, J. Spellberg, J. Luis de la Pompa, A. Elia, A. Wakeham, B. Karan-Tamir, et al. Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions J. Immunol., March 1, 1999; 162(5): 3022 - 3030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Serebruany and P. A. Gurbel Effect of Thrombolytic Therapy on Platelet Expression and Plasma Concentration of PECAM-1 (CD31) in Patients With Acute Myocardial Infarction Arterioscler. Thromb. Vasc. Biol., January 1, 1999; 19(1): 153 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. DeLisser and S. M. Albelda The Function of Cell Adhesion Molecules in Lung Inflammation: More Questions Than Answers Am. J. Respir. Cell Mol. Biol., October 1, 1998; 19(4): 533 - 536. [Full Text]
|
|
|
|
 |
|
 Y. Shen, C. Sultana, M. Arditi, K. S. Kim, and V. K. Kalra Endotoxin-induced migration of monocytes and PECAM-1 phosphorylation are abrogated by PAF receptor antagonists Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E479 - E486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. O. Nossuli, R. Hayward, D. Jensen, R. Scalia, and A. M. Lefer Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H509 - H519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-H. Sun, C. Paddock, G. P. Visentin, M. M. Zukowski, W. A. Muller, and P. J. Newman Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1. PECAM-1 IS NOT A HEPARIN-BINDING PROTEIN J. Biol. Chem., May 8, 1998; 273(19): 11483 - 11490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets Blood, January 15, 1998; 91(2): 500 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sagawa, T. Kimura, M. Swieter, and R. P. Siraganian The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31) J. Biol. Chem., December 5, 1997; 272(49): 31086 - 31091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-W. Wu and E. C.-Y. Lian Binding Properties and Inhibition of Platelet Aggregation by a Monoclonal Antibody to CD31 (PECAM-1) Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 3154 - 3158. [Abstract] [Full Text]
|
|
|
|
|
|
T. O. Nossuli, R. Hayward, R. Scalia, and A. M. Lefer Peroxynitrite Reduces Myocardial Infarct Size and Preserves Coronary Endothelium After Ischemia and Reperfusion in Cats Circulation, October 7, 1997; 96(7): 2317 - 2324. [Abstract] [Full Text]
|
|
|
|
|
|
J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31 J. Biol. Chem., August 15, 1997; 272(33): 20555 - 20563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sagawa, W. Swaim, J. Zhang, E. Unsworth, and R. P. Siraganian Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31) J. Biol. Chem., May 16, 1997; 272(20): 13412 - 13418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Liao, J. Ali, T. Greene, and W. A. Muller Soluble Domain 1 of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo J. Exp. Med., April 7, 1997; 185(7): 1349 - 1358. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
