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The Journal of Immunology, Vol 156, Issue 7 2458-2464, Copyright © 1996 by American Association of Immunologists

ARTICLES

Extensive diversity of transcribed TCR-beta in phylogenetically primitive vertebrate

NA Hawke, JP Rast and GW Litman
Department of Medical Microbiology and Immunology, University of South Florida, Tampa 33612, USA.

The genetic complexity of the expressed TCR Vbeta repertoire in Heterodontus francisci, the horned shark, a member of the most phylogenetically primitive vertebrate class in which TCR genes have been identified, is addressed. The sequences of 55 spleen cDNA clones encoding TCR-beta genes are compared, and 7 diverse Vbeta families are defined by overall sequence identity and clustering based on phylogenetic distance analyses. At least 18 putative Jbeta sequence types, as well as a consensus diversity (D) element that resembles most closely mammalian TCR Dbeta, can he recognized. Extensive sequence diversity, as well as characteristic TCR-beta length variation in CDR3, is evident. Unlike Ig genes in this species, TCR-beta genes exhibit considerable V family multiplicity and appear to utilize combinatorial mechanisms in the generation of immunologic diversity. in this sense, the TCR-beta genes in this cartilaginous fish and humans are more similar than are the genes encoding Ab proteins in these species.


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