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The Journal of Immunology, Vol 156, Issue 7 2361-2364, Copyright © 1996 by American Association of Immunologists

CUTTING EDGE

Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit

D Nandi, H Jiang and JJ Monaco
Department of Molecular Genetics; Howard Hughes Medical Insitute, University of Cincinnati, Ohio 452167, USA.

We show that six proteasome-associated proteins are induced by IFN- gamma, corresponding to three proteasome beta-type subunits and their precursors: the MHC-linked subunits (LMP-2 and LMP-7) and LMP-10. Concurrently, incorporation of LMP-9, LMP-17, and LMP-19 into proteasomes is reduced. LMP-10 appears to be the product of a previously cloned proteasome subunit gene, MECL-1. MECL-1 transcription is increased in the presence of IFN-gamma, whereas the transcription of two other proteasome genes, Lmp-15 and Lmp-3, is not affected. The three IFN-gamma-inducible subunits and their constitutively expressed counterparts contain most or all of the catalytic sites of the proteasome. Independent assortment of LMP-2, LMP-7, and LMP-10 into different proteasome complexes may thus generate up to 36 unique proteasome subsets. This may increase the repertoire of potentially antigenic peptides for presentation by MHC class I.


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