| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 156, Issue 7 2357-2360, Copyright © 1996 by American Association of Immunologists
CUTTING EDGE |
S Ehl, U Hoffmann-Rohrer, S Nagata, H Hengartner and R Zinkernagel
Insitute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland.
To address the question of whether cytotoxic CD8+ T cells (CTL) activated in vivo are susceptible to cell death mediated by CD95 (Fas/Apo-1) ligand, a recombinant vaccinia virus expressing murine CD95L (vacc CD95L) was constructed, which drives CD95L expression to infected cells. T cells contacting virus-infected cells during priming, killing, or restimulation therefore encounter CD95L on the same cells. CD95L expression in vivo after infection with the vaccinia recombinant was sufficient to induce extensive necrosis in the liver of normal but not of CD95 mutant lpr mice. Fibroblast cell lines infected with this virus specifically killed CD95-transfected target cells and in vitro activated T cells. In contrast, when T cells were activated by a viral infection in vivo, they were not susceptible to CD95L-mediated cell death during the induction, effector, or memory phase in vitro or in vivo. These results suggest no direct role for CD95L in regulating CTL responses in vivo.
This article has been cited by other articles:
|
|
 |
|
  J. H. Kim, E. Y. Choi, and D. H. Chung Donor Bone Marrow Type II (Non-V{alpha}14J{alpha}18 CD1d-Restricted) NKT Cells Suppress Graft-Versus-Host Disease by Producing IFN-{gamma} and IL-4 J. Immunol., November 15, 2007; 179(10): 6579 - 6587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Onoe, H. Ohdan, D. Tokita, M. Shishida, Y. Tanaka, H. Hara, W. Zhou, K. Ishiyama, H. Mitsuta, K. Ide, et al. Liver Sinusoidal Endothelial Cells Tolerize T Cells across MHC Barriers in Mice J. Immunol., July 1, 2005; 175(1): 139 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Maeda, R. B. Levy, P. Reddy, C. Liu, S. G. Clouthier, T. Teshima, and J. L. M. Ferrara Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease Blood, March 1, 2005; 105(5): 2023 - 2027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. McKarns and R. H. Schwartz Distinct Effects of TGF-{beta}1 on CD4+ and CD8+ T Cell Survival, Division, and IL-2 Production: A Role for T Cell Intrinsic Smad3 J. Immunol., February 15, 2005; 174(4): 2071 - 2083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Min, Y. Maeda, K. Lowler, C. Liu, S. Clouthier, D. Lofthus, E. Weisiger, J. L. M. Ferrara, and P. Reddy Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation Blood, November 15, 2004; 104(10): 3393 - 3399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Davey, C. Kurts, J. F.A.P. Miller, P. Bouillet, A. Strasser, A. G. Brooks, F. R. Carbone, and W. R. Heath Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2-inhibitable Pathway Mediated by Bim J. Exp. Med., October 7, 2002; 196(7): 947 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Gregory, A. C. Repp, A. M. Holhbaum, R. R. Saff, A. Marshak-Rothstein, and B. R. Ksander Membrane Fas Ligand Activates Innate Immunity and Terminates Ocular Immune Privilege J. Immunol., September 1, 2002; 169(5): 2727 - 2735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. Igney and P. H. Krammer Immune escape of tumors: apoptosis resistance and tumor counterattack J. Leukoc. Biol., June 1, 2002; 71(6): 907 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kim, K. A. Whartenby, R. W. Georgantas III, J. Wingard, and C. I. Civin Human CD34+ Hematopoietic Stem/Progenitor Cells Express High Levels of FLIP and Are Resistant to Fas-Mediated Apoptosis Stem Cells, March 1, 2002; 20(2): 174 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Parsons, R. G. Jones, M.-S. Tsao, B. Odermatt, P. S. Ohashi, and J. R. Woodgett Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation J. Immunol., July 1, 2001; 167(1): 42 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Auphan-Anezin and A.-M. Schmitt-Verhulst Differential Survival of Transferred CD8 T Cells and Host Reconstitution Depending on TCR Avidity for Host-Expressed Alloantigen J. Immunol., June 15, 2001; 166(12): 7200 - 7207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Huang and M. L. Tykocinski CTLA-4-Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells Int. Immunol., April 1, 2001; 13(4): 529 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Wei, H. Yagita, M. G. Masucci, and V. Levitsky Different Programs of Activation-Induced Cell Death Are Triggered in Mature Activated CTL by Immunogenic and Partially Agonistic Peptide Ligands J. Immunol., January 15, 2001; 166(2): 989 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Suzuki and P. J. Fink The dual functions of Fas ligand in the regulation of peripheral CD8+ and CD4+ T cells PNAS, February 15, 2000; 97(4): 1707 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bertolino, M.-C. Trescol-Biemont, J. Thomas, B. F. de St Groth, M. Pihlgren, J. Marvel, and C. Rabourdin-Combe Death by neglect as a deletional mechanism of peripheral tolerance Int. Immunol., August 1, 1999; 11(8): 1225 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brochu, B. Rioux-Masse, J. Roy, D.-C. Roy, and C. Perreault Massive Activation-Induced Cell Death of Alloreactive T Cells With Apoptosis of Bystander Postthymic T Cells Prevents Immune Reconstitution in Mice With Graft-Versus-Host Disease Blood, July 15, 1999; 94(2): 390 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Chappell, T. Z. Zaks, S. A. Rosenberg, and N. P. Restifo Human Melanoma Cells Do Not Express Fas (Apo-1/CD95) Ligand Cancer Res., January 1, 1999; 59(1): 59 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kurts, W. R. Heath, H. Kosaka, J. F.A.P. Miller, and F. R. Carbone The Peripheral Deletion of Autoreactive CD8+ T Cells Induced by Cross-presentation of Self-antigens Involves Signaling through CD95 (Fas, Apo-1) J. Exp. Med., July 20, 1998; 188(2): 415 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Suzuki and P. J. Fink Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand J. Exp. Med., January 5, 1998; 187(1): 123 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Smyth and J. A. Trapani The Relative Role of Lymphocyte Granule Exocytosis versus Death Receptor-Mediated Cytotoxicity in Viral Pathophysiology J. Virol., January 1, 1998; 72(1): 1 - 9. [Full Text] [PDF]
|
|
|
|
|
|
R. P. Johnson Upregulation of Fas Ligand by Simian Immunodeficiency Virus---A nef-arious Mechanism of Immune Evasion? J. Exp. Med., July 7, 1997; 186(1): 1 - 5. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
