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The Journal of Immunology, Vol 156, Issue 7 2352-2356, Copyright © 1996 by American Association of Immunologists
CUTTING EDGE |
DW Scott, T Grdina and Y Shi
Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA.
In addition to self tolerance, the immune system needs to be regulated when a response has been initiated. Recent data suggest that activated T and B cells, as well as immature lymphocytes, are susceptible to programmed cell death and that Fas:Fas ligand (FasL) interactions play an important role in this process. However, while T cells may kill themselves via a Fas-dependent pathway, we propose that B cells undergo activation-induced apoptosis independent of Fas, yet can be susceptible to T cell-mediated, FasL-induced death. Therefore, T cells can commit suicide, but B cells are murdered during the regulation of an immune response! Further evidence is presented to support the hypothesis that T cell and B cell apoptosis, are initiated through fundamentally different pathways.
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