The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kehry, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kehry, M.

The Journal of Immunology, Vol 156, Issue 7 2345-2348, Copyright © 1996 by American Association of Immunologists

CUTTING EDGE

Commentary: CD40-mediated signaling in B cells. Balancing cell survival, growth, and death

MR Kehry
Department of Immunological Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefeild, CT 06877, USA.

Multimerization of CD40 molecules on B cells by binding CD40 ligand on activated T cells initiates signaling events essential for B cell differentiation. In mature B cells, CD40 mediates stimulation and costimulation of cell growth, switch recombination, and transcriptional regulation. CD40-mediated signaling also regulates cell death, rescuing B cells from anti-Ig-induced apoptosis and inducing the expression of the Fas surface molecule. Recent efforts to elucidate the biochemistry of CD40-mediated signaling pathways have identified members of the TRAF protein family that are associated with the cytoplasmic tail of CD40. CD40 cross-linking probably multimerizes TRAF proteins which may act as direct transcriptional regulators. Modulation of protein tyrosine kinase and protein tyrosine phosphatase activity also occurs after CD40- mediated signaling; however, a connection to the TRAF pathway has not been established. Multiple pathways of B cell triggering are probably integrated at the level of transcriptional activation to produce differentiation stage-specific B cell responses.


This article has been cited by other articles:


Home page
 haematolHome page
J.-J. Goval, C. Thielen, C. Bourguignon, R. Greimers, E. Dejardin, Y. S. Choi, J. Boniver, and L. de Leval
The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP
Haematologica, August 1, 2008; 93(8): 1169 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Travert, P. Ame-Thomas, C. Pangault, A. Morizot, O. Micheau, G. Semana, T. Lamy, T. Fest, K. Tarte, and T. Guillaudeux
CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-{kappa}B Activation and Up-Regulation of c-FLIP and Bcl-xL
J. Immunol., July 15, 2008; 181(2): 1001 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. D. Mineva, T. L. Rothstein, J. A. Meyers, A. Lerner, and G. E. Sonenshein
CD40 Ligand-mediated Activation of the de Novo RelB NF-{kappa}B Synthesis Pathway in Transformed B Cells Promotes Rescue from Apoptosis
J. Biol. Chem., June 15, 2007; 282(24): 17475 - 17485.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Zirlik, U. Bavendiek, P. Libby, L. MacFarlane, N. Gerdes, J. Jagielska, S. Ernst, M. Aikawa, H. Nakano, E. Tsitsikov, et al.
TRAF-1, -2, -3, -5, and -6 Are Induced in Atherosclerotic Plaques and Differentially Mediate Proinflammatory Functions of CD40L in Endothelial Cells
Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1101 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Bilancio, K. Okkenhaug, M. Camps, J. L. Emery, T. Ruckle, C. Rommel, and B. Vanhaesebroeck
Key role of the p110{delta} isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110{delta} function in B cells
Blood, January 15, 2006; 107(2): 642 - 650.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A Ogawa, T Tagawa, H Nishimura, T Yajima, T Abe, T Arai, M Taniguchi, K Takeda, S Akira, Y Nimura, et al.
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice
Gut, January 1, 2006; 55(1): 105 - 113.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H.-C. Chuang, J.-D. Lay, W.-C. Hsieh, H.-C. Wang, Y. Chang, S.-E. Chuang, and I.-J. Su
Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome
Blood, November 1, 2005; 106(9): 3090 - 3096.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. R. Herrin, A. L. Groeger, and L. B. Justement
The Adaptor Protein HSH2 Attenuates Apoptosis in Response to Ligation of the B Cell Antigen Receptor Complex on the B Lymphoma Cell Line, WEHI-231
J. Biol. Chem., February 4, 2005; 280(5): 3507 - 3515.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. L. Drayton, G. Bonizzi, X. Ying, S. Liao, M. Karin, and N. H. Ruddle
I{kappa}B Kinase Complex {alpha} Kinase Activity Controls Chemokine and High Endothelial Venule Gene Expression in Lymph Nodes and Nasal-Associated Lymphoid Tissue
J. Immunol., November 15, 2004; 173(10): 6161 - 6168.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A.-J. Ruth, A. R. Kitching, M. Li, T. J. Semple, J. R. Timoshanko, P. G. Tipping, and S. R. Holdsworth
An IL-12-Independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-Mediated Glomerulonephritis and Dermal Delayed-Type Hypersensitivity
J. Immunol., July 1, 2004; 173(1): 136 - 144.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Flaxenburg, M. Melter, P. H. Lapchak, D. M. Briscoe, and S. Pal
The CD40-Induced Signaling Pathway in Endothelial Cells Resulting in the Overexpression of Vascular Endothelial Growth Factor Involves Ras and Phosphatidylinositol 3-Kinase
J. Immunol., June 15, 2004; 172(12): 7503 - 7509.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. M. Siwkowski, L. Malik, C. C. Esau, M. A. Maier, E. V. Wancewicz, K. Albertshofer, B. P. Monia, C. F. Bennett, and A. B. Eldrup
Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing
Nucleic Acids Res., May 17, 2004; 32(9): 2695 - 2706.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. Duddy, A. Alter, and A. Bar-Or
Distinct Profiles of Human B Cell Effector Cytokines: A Role in Immune Regulation?
J. Immunol., March 15, 2004; 172(6): 3422 - 3427.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. N. D'Souza, L. C. Edelstein, P. M. Pegman, S. M. Smith, S. T. Loughran, A. Clarke, A. Mehl, M. Rowe, C. Gelinas, and D. Walls
Nuclear Factor {kappa}B-Dependent Activation of the Antiapoptotic bfl-1 Gene by the Epstein-Barr Virus Latent Membrane Protein 1 and Activated CD40 Receptor
J. Virol., February 15, 2004; 78(4): 1800 - 1816.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Kaufman, P. J. Sime, and R. P. Phipps
Expression of CD154 (CD40 Ligand) by Human Lung Fibroblasts: Differential Regulation by IFN-{gamma} and IL-13, and Implications for Fibrosis
J. Immunol., February 1, 2004; 172(3): 1862 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K.-I. Imadome, M. Shirakata, N. Shimizu, S. Nonoyama, and Y. Yamanashi
CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation
PNAS, June 24, 2003; 100(13): 7836 - 7840.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Craxton, D. Magaletti, E. J. Ryan, and E. A. Clark
Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF
Blood, June 1, 2003; 101(11): 4464 - 4471.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Grassme, V. Jendrossek, J. Bock, A. Riehle, and E. Gulbins
Ceramide-Rich Membrane Rafts Mediate CD40 Clustering
J. Immunol., January 1, 2002; 168(1): 298 - 307.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
U. Schonbeck and P. Libby
CD40 Signaling and Plaque Instability
Circ. Res., December 7, 2001; 89(12): 1092 - 1103.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. M. Mehl, M. Jones, M. Rowe, and P. Brennan
Characterization of a CD40-Dominant Inhibitory Receptor Mutant
J. Immunol., December 1, 2001; 167(11): 6388 - 6393.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. G. Werneburg, S. J. Zoog, T. T. A. Dang, M. R. Kehry, and J. J. Crute
Molecular Characterization of CD40 Signaling Intermediates
J. Biol. Chem., November 9, 2001; 276(46): 43334 - 43342.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Hinz, P. Loser, S. Mathas, D. Krappmann, B. Dorken, and C. Scheidereit
Constitutive NF-{kappa}B maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
Blood, May 1, 2001; 97(9): 2798 - 2807.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
A. BRAS, A. RUIZ-VELA, D. GARCIA-DOMINGO, and C. MARTINEZ-A
Apoptosis as a Scaffold for Building up the B Cell Repertoire
Ann. N.Y. Acad. Sci., December 1, 2000; 926(1): 13 - 29.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. A. Bishop, Y. Hsing, B. S. Hostager, S. V. Jalukar, L. M. Ramirez, and M. A. Tomai
Molecular Mechanisms of B Lymphocyte Activation by the Immune Response Modifier R-848
J. Immunol., November 15, 2000; 165(10): 5552 - 5557.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Andjelic, C. Hsia, H. Suzuki, T. Kadowaki, S. Koyasu, and H.-C. Liou
Phosphatidylinositol 3-Kinase and NF-{kappa}B/Rel Are at the Divergence of CD40-Mediated Proliferation and Survival Pathways
J. Immunol., October 1, 2000; 165(7): 3860 - 3867.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Cerutti, A. Schaffer, R. G. Goodwin, S. Shah, H. Zan, S. Ely, and P. Casali
Engagement of CD153 (CD30 Ligand) by CD30+ T Cells Inhibits Class Switch DNA Recombination and Antibody Production in Human IgD+ IgM+ B Cells
J. Immunol., July 15, 2000; 165(2): 786 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. P. Phipps
Atherosclerosis: The emerging role of inflammation and the CD40-CD40 ligand system
PNAS, June 20, 2000; 97(13): 6930 - 6932.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
U. Schonbeck, G. K. Sukhova, K. Shimizu, F. Mach, and P. Libby
Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
PNAS, June 20, 2000; 97(13): 7458 - 7463.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Bhushan, B. Barnhart, S. Shone, C. Song, and L. R. Covey
A Transcriptional Defect Underlies B Lymphocyte Dysfunction in a Patient Diagnosed with Non-X-Linked Hyper-IgM Syndrome
J. Immunol., March 15, 2000; 164(6): 2871 - 2880.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Chirmule, J. Tazelaar, and J. M. Wilson
Th2-Dependent B Cell Responses in the Absence of CD40-CD40 Ligand Interactions
J. Immunol., January 1, 2000; 164(1): 248 - 255.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Aicher, G. L. Shu, D. Magaletti, T. Mulvania, A. Pezzutto, A. Craxton, and E. A. Clark
Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells
J. Immunol., December 1, 1999; 163(11): 5786 - 5795.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. Ozaki, B. A. Coren, T. N. Huynh, D. J. Redondo, H. Kikutani, and S. R. Webb
CD4+ T Cell Responses to CD40-Deficient APCs: Defects in Proliferation and Negative Selection Apply Only with B Cells as APCs
J. Immunol., November 15, 1999; 163(10): 5250 - 5256.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. H. Lee, H. Dadgostar, Q. Cheng, J. Shu, and G. Cheng
NF-kappa B-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
PNAS, August 3, 1999; 96(16): 9136 - 9141.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. M. Izumi, E. C. McFarland, A. T. Ting, E. A. Riley, B. Seed, and E. D. Kieff
The Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 Engages the Tumor Necrosis Factor Receptor-Associated Proteins TRADD and Receptor-Interacting Protein (RIP) but Does Not Induce Apoptosis or Require RIP for NF-kappa B Activation
Mol. Cell. Biol., August 1, 1999; 19(8): 5759 - 5767.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. R. Posner, L. A. Cavacini, M. P. Upton, K. C. Tillman, E. R. Gornstein, and C. M. Norris Jr.
Surface Membrane-expressed CD40 Is Present on Tumor Cells from Squamous Cell Cancer of the Head and Neck in Vitro and in Vivo and Regulates Cell Growth in Tumor Cell Lines
Clin. Cancer Res., August 1, 1999; 5(8): 2261 - 2270.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. S. Pullen, T. T. A. Dang, J. J. Crute, and M. R. Kehry
CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs). BINDING SITE SPECIFICITY AND ACTIVATION OF DOWNSTREAM PATHWAYS BY DISTINCT TRAFs
J. Biol. Chem., May 14, 1999; 274(20): 14246 - 14254.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. Leveille, H. Zekki, R. Al-Daccak, and W. Mourad
CD40- and HLA-DR-mediated cell death pathways share a lot of similarities but differ in their use of ADP-ribosyltransferase activities
Int. Immunol., May 1, 1999; 11(5): 719 - 730.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. K. Busch and G. A. Bishop
The EBV Transforming Protein, Latent Membrane Protein 1, Mimics and Cooperates with CD40 Signaling in B Lymphocytes
J. Immunol., March 1, 1999; 162(5): 2555 - 2561.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
G. G. B. Klaus, M. Holman, C. Johnson-Leger, J. R. Christenson, and M. R. Kehry
Interaction of B cells with activated T cells reduces the threshold for CD40-mediated B cell activation
Int. Immunol., January 1, 1999; 11(1): 71 - 79.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Li and R. H. Carter
Convergence of CD19 and B Cell Antigen Receptor Signals at MEK1 in the ERK2 Activation Cascade
J. Immunol., December 1, 1998; 161(11): 5901 - 5908.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. D. Sharma, M. Leite de Moraes, F. Zavala, C. Pontoux, and M. Papiernik
Induction and Inhibition of CD40-CD40 Ligand Interactions: A New Strategy Underlying Host-Virus Relationships
J. Immunol., November 15, 1998; 161(10): 5357 - 5365.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Kato, N. Motoyama, I. Taniuchi, H. Takeshita, M. Toyoda, K. Masuda, and T. Watanabe
Affinity Maturation in Lyn Kinase-Deficient Mice with Defective Germinal Center Formation
J. Immunol., May 15, 1998; 160(10): 4788 - 4795.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. C. Gilfillan, P. J. Noel, E. R. Podack, S. L. Reiner, and C. B. Thompson
Expression of the Costimulatory Receptor CD30 Is Regulated by Both CD28 and Cytokines
J. Immunol., March 1, 1998; 160(5): 2180 - 2187.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. M. Izumi and E. D. Kieff
The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappa B
PNAS, November 11, 1997; 94(23): 12592 - 12597.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. M. Izumi, K. M. Kaye, and E. D. Kieff
The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation
PNAS, February 18, 1997; 94(4): 1447 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Ingham, D. L. Krebs, S. M. Barbazuk, C. W. Turck, H. Hirai, M. Matsuda, and M. R. Gold
B Cell Antigen Receptor Signaling Induces the Formation of Complexes Containing the Crk Adapter Proteins
J. Biol. Chem., December 13, 1996; 271(50): 32306 - 32314.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Patil, G. M. Wildey, T. L. Brown, L. Choy, R. Derynck, and P. H. Howe
Smad7 Is Induced by CD40 and Protects WEHI 231 B-lymphocytes from Transforming Growth Factor-beta -induced Growth Inhibition and Apoptosis
J. Biol. Chem., December 1, 2000; 275(49): 38363 - 38370.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.