The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kwok, W. W.
Right arrow Articles by Nepom, G. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kwok, W. W.
Right arrow Articles by Nepom, G. T.

The Journal of Immunology, Vol 156, Issue 6 2171-2177, Copyright © 1996 by American Association of Immunologists

ARTICLES

Allele-specific motifs characterize HLA-DQ interactions with a diabetes- associated peptide derived from glutamic acid decarboxylase

WW Kwok, ML Domeier, FC Raymond, P Byers and GT Nepom
Virginia Mason Research Center, Seattle, WA 98101, USA.

Polymorphic residues of HLA class II molecules influence immune activation in part by determining specific structural constraints for binding antigenic peptides. We identified a peptide from glutamic acid decarboxylase, a diabetes-associated autoantigen that preferentially bound to HLA-DQ3.2 molecules, one of the HLA determinants highly associated with insulin-dependent diabetes. We analyzed interactions of specific HLA-DQ residues with modified peptide analogues and found a pattern of permissive site-specific amino acids that accommodated allele-specific binding. Four anchor residues constrain binding to different DQ alleles; limited variation at two of these sites, residues 4 and 9, accounts for the unique pattern of peptide binding to HLA- DQ3.1 or HLA-DQ3.2.


This article has been cited by other articles:


Home page
 GutHome page
C Mitea, R Havenaar, J W. Drijfhout, L Edens, L Dekking, and F Koning
Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease
Gut, January 1, 2008; 57(1): 25 - 32.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. A. Ettinger, G. K. Papadopoulos, A. K. Moustakas, G. T. Nepom, and W. W. Kwok
Allelic Variation in Key Peptide-Binding Pockets Discriminates between Closely Related Diabetes-Protective and Diabetes-Susceptible HLA-DQB1*06 Alleles
J. Immunol., February 1, 2006; 176(3): 1988 - 1998.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Senger, F. Maurano, M. F. Mazzeo, M. Gaita, O. Fierro, C. S. David, R. Troncone, S. Auricchio, R. A. Siciliano, and M. Rossi
Identification of Immunodominant Epitopes of {alpha}-Gliadin in HLA-DQ8 Transgenic Mice following Oral Immunization
J. Immunol., December 15, 2005; 175(12): 8087 - 8095.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
M. F. Mazzeo, B. De Giulio, S. Senger, M. Rossi, A. Malorni, and R. A. Siciliano
Identification of transglutaminase-mediated deamidation sites in a recombinant {alpha}-gliadin by advanced mass-spectrometric methodologies
Protein Sci., November 1, 2003; 12(11): 2434 - 2442.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. C. Iannuzzi, M. J. Maliarik, L. M. Poisson, and B. A. Rybicki
Sarcoidosis Susceptibility and Resistance HLA-DQB1 Alleles in African Americans
Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1225 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pathol.Home page
M A Kelly, M L Rayner, C H Mijovic, and A H Barnett
Molecular aspects of type 1 diabetes
Mol. Pathol., February 1, 2003; 56(1): 1 - 10.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Sidney, M.-F. del Guercio, S. Southwood, and A. Sette
The HLA Molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 Share an Extensive Overlap in Peptide Binding Specificity
J. Immunol., November 1, 2002; 169(9): 5098 - 5108.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Graham, W. A. Hagopian, I. Kockum, L. S. Li, C. B. Sanjeevi, R. M. Lowe, J. B. Schaefer, M. Zarghami, H. L. Day, M. Landin-Olsson, et al.
Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes
Diabetes, May 1, 2002; 51(5): 1346 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
L. W. Vader, A. de Ru, Y. van der Wal, Y. M.C. Kooy, W. Benckhuijsen, M. L. Mearin, J. W. Drijfhout, P. van Veelen, and F. Koning
Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac Disease
J. Exp. Med., March 4, 2002; 195(5): 643 - 649.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Suri, I. Vidavsky, K. van der Drift, O. Kanagawa, M. L. Gross, and E. R. Unanue
In APCs, the Autologous Peptides Selected by the Diabetogenic I-Ag7 Molecule Are Unique and Determined by the Amino Acid Changes in the P9 Pocket
J. Immunol., February 1, 2002; 168(3): 1235 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
F. Cucca, R. Lampis, M. Congia, E. Angius, S. Nutland, S. C. Bain, A. H. Barnett, and J. A. Todd
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
Hum. Mol. Genet., September 1, 2001; 10(19): 2025 - 2037.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Snijders, D. G. Elferink, A. Geluk, A. L. van der Zanden, K. Vos, G. M. T. Schreuder, F. C. Breedveld, R. R. P. de Vries, and E. H. Zanelli
An HLA-DRB1-Derived Peptide Associated with Protection Against Rheumatoid Arthritis Is Naturally Processed by Human APCs
J. Immunol., April 15, 2001; 166(8): 4987 - 4993.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. S. Abraham, L. Wen, E. V. Marietta, and C. S. David
Type 1 Diabetes-Predisposing MHC Alleles Influence the Selection of Glutamic Acid Decarboxylase (GAD) 65-Specific T Cells in a Transgenic Model
J. Immunol., January 15, 2001; 166(2): 1370 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. A. Ettinger, A. W. Liu, G. T. Nepom, and W. W. Kwok
{beta}57-Asp Plays an Essential Role in the Unique SDS Stability of HLA-DQA1*0102/DQB1*0602 {alpha}{beta} Protein Dimer, the Class II MHC Allele Associated with Protection from Insulin-Dependent Diabetes Mellitus
J. Immunol., September 15, 2000; 165(6): 3232 - 3238.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. K. Moustakas, Y. van de Wal, J. Routsias, Y. M. C. Kooy, P. van Veelen, J. W. Drijfhout, F. Koning, and G. K. Papadopoulos
Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes
Int. Immunol., August 1, 2000; 12(8): 1157 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
Y VAN DE WAL, Y KOOY, P VAN VEELEN, W VADER, F KONING, and S PENA
Coeliac disease: it takes three to tango!
Gut, May 1, 2000; 46(5): 734 - 737.
[Full Text] [PDF]

Home page
 Int ImmunolHome page
S. Gregori, E. Bono, F. Gallazzi, J. Hammer, L. C. Harrison, and L. Adorini
The motif for peptide binding to the insulin-dependent diabetes mellitus-associated class II MHC molecule I-Ag7 validated by phage display library
Int. Immunol., April 1, 2000; 12(4): 493 - 503.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
H. Arentz-Hansen, R. Korner, O. Molberg, H. Quarsten, W. Vader, Y. M.C. Kooy, K. E.A. Lundin, F. Koning, P. Roepstorff, L. M. Sollid, et al.
The Intestinal T Cell Response to {alpha}-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase
J. Exp. Med., February 21, 2000; 191(4): 603 - 612.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. C. Steele, S. P. Young, J. C. Goodall, and P. H. Gallimore
Structural Aspects of the Interaction Between Heterogeneic Human Papillomavirus Type 1 E4-Specific T Cell Receptors and the Same Peptide/HLA-DQ8 Complex
J. Immunol., November 1, 1998; 161(9): 4745 - 4752.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. van de Wal, Y. Kooy, P. van Veelen, S. Pena, L. Mearin, G. Papadopoulos, and F. Koning
Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity
J. Immunol., August 15, 1998; 161(4): 1585 - 1588.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. A. Ettinger and W. W. Kwok
A Peptide Binding Motif for HLA-DQA1*0102/DQB1*0602, the Class II MHC Molecule Associated with Dominant Protection in Insulin-Dependent Diabetes Mellitus
J. Immunol., March 1, 1998; 160(5): 2365 - 2373.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.