| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 156, Issue 5 1756-1763, Copyright © 1996 by American Association of Immunologists
ARTICLES |
F Momburg, EA Armandola, M Post and GJ Hammerling
Department of Molecular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
The transporter associated with Ag processing (TAP) translocates peptides from the cytosol into the endoplasmic reticulum where they associate with MHC class I molecules. Two specificity patterns with regard to the C-terminal residue of transported peptides have been previously shown. While the u allele of rat TAP and the mouse TAP preferentially transport peptides with hydrophobic C-terminal residues, no such selection was reported for the a allele of rat TAP or for the human TAP. We were able to map two short stretches in rat TAP2, with two polymorphic residues each, that essentially control the differential peptide transport observed for the rat alleles by constructing several hybrids between rat TAP2a and TAP2u and co- expressing them with rat TAP1 in TAP-deficient T2 cells. The critical residues are located in putative cytoplasmic loops close to the membrane.
This article has been cited by other articles:
|
|
 |
|
  O. Hershkovitz, M. Jarahian, A. Zilka, A. Bar-Ilan, G. Landau, S. Jivov, Y. Tekoah, R. Glicklis, J. T. Gallagher, S. C. Hoffmann, et al. Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool Glycobiology, January 1, 2008; 18(1): 28 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Daza-Vamenta, G. Glusman, L. Rowen, B. Guthrie, and D. E. Geraghty Genetic Divergence of the Rhesus Macaque Major Histocompatibility Complex Genome Res., August 1, 2004; 14(8): 1501 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Velarde, R. C. Ford, M. F. Rosenberg, and S. J. Powis Three-dimensional Structure of Transporter Associated with Antigen Processing (TAP) Obtained by Single Particle Image Analysis J. Biol. Chem., November 30, 2001; 276(49): 46054 - 46063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Ritz, F. Momburg, H.-P. Pircher, D. Strand, C. Huber, and B. Seliger Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) function Int. Immunol., January 1, 2001; 13(1): 31 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Vos, P. Spee, F. Momburg, and J. Neefjes Membrane Topology and Dimerization of the Two Subunits of the Transporter Associated with Antigen Processing Reveal a Three-Domain Structure J. Immunol., December 15, 1999; 163(12): 6679 - 6685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Hansen, P. Strassburger, G. H. Thorgaard, W. P. Young, and L. Du Pasquier Expression, Linkage, and Polymorphism of MHC-Related Genes in Rainbow Trout, Oncorhynchus mykiss J. Immunol., July 15, 1999; 163(2): 774 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Yan, L. Shi, and D. Faustman Novel Splicing of the Human MHC-Encoded Peptide Transporter Confers Unique Properties J. Immunol., January 15, 1999; 162(2): 852 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Deverson, L. Leong, A. Seelig, W. J. Coadwell, E. M. Tredgett, G. W. Butcher, and J. C. Howard Functional Analysis by Site-Directed Mutagenesis of the Complex Polymorphism in Rat Transporter Associated with Antigen Processing J. Immunol., March 15, 1998; 160(6): 2767 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang, C. Raynoschek, K. Svensson, and H.-G. Ljunggren Binding of H-2Kb-specific Peptides to TAP and Major Histocompatibility Complex Class I in Microsomes from Wild-type, TAP1, and beta 2-Microglobulin Mutant Mice J. Biol. Chem., October 4, 1996; 271(40): 24830 - 24835. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
