The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chorinchath, B. B.
Right arrow Articles by McCallum, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chorinchath, B. B.
Right arrow Articles by McCallum, R. E.

The Journal of Immunology, Vol 156, Issue 4 1525-1530, Copyright © 1996 by American Association of Immunologists

ARTICLES

Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice

BB Chorinchath, LY Kong, L Mao and RE McCallum
Department of Medical Microbiology and Immunology, Texas A&M University Health Science Center, College Station 77843-1114, USA.

Gram-negative bacterial infection is a common cause of septic shock in the older population in the U.S. We employed an experimental model of sepsis to study the cause of increased lethality due to LPS in older animals. Three ages of male B6JC3J/Nia mice, young (2 mo old), mature (12 mo old), and senescent (24 mo old), were treated with bacterial LPS, and the older mice were found to be 10 times more sensitive to LPS lethality. Increased sensitivity to LPS in senescent mice correlated with significantly elevated plasma TNF-alpha and nitric oxide levels. Abs to TNF-alpha afforded aged animals passive protection against a supralethal dose of LPS, establishing a central role for TNF in the increased sensitivity to LPS seen in the aged animals. Other cytokines, such as IL-1 and IFN-gamma, appeared secondary to TNF and nitric oxide in the age-associated sensitivity to LPS. Plasma corticosterone levels were increased by LPS at a time when maximal levels of plasma TNF-alpha were observed in both age groups, although the kinetics of hormone production and the magnitude of TNF-alpha release varied among the age groups. Exogenously administered dexamethasone protected senescent animals given a high dose of LPS, by decreasing cytokine levels. The increased sensitivity to LPS observed in aged animals, therefore, seems to be due to excessive TNF and nitric oxide production, resulting from perturbed endogenous hormonal control of cytokine production.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. P. Krzyszton, N. L. Sparkman, R. W. Grant, J. B. Buchanan, S. R. Broussard, J. Woods, and R. W. Johnson
Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1109 - R1114.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
S. Blad, A.-K. Welin, I. Kjellmer, K.G. Rosen, and C. Mallard
ECG and Heart Rate Variability Changes in Preterm and Near-Term Fetal Lamb Following LPS Exposure
Reproductive Sciences, July 1, 2008; 15(6): 572 - 583.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
B. M. Meador, C. P. Krzyszton, R. W. Johnson, and K. A. Huey
Effects of IL-10 and age on IL-6, IL-1{beta}, and TNF-{alpha} responses in mouse skeletal and cardiac muscle to an acute inflammatory insult
J Appl Physiol, April 1, 2008; 104(4): 991 - 997.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
C. Nieves Jr, H. S. Sitren, K. A. Herrlinger-Garcia, and B. Langkamp-Henken
Pharmacologic Levels of Dietary Arginine in CB6F1 Mice Increase Serum Ammonia in the Healthy State and Serum Nitrite in Endotoxemia
JPEN J Parenter Enteral Nutr, March 1, 2007; 31(2): 101 - 108.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y. Shoshani, J. Pe'er, V. Doviner, J. Frucht-Pery, and A. Solomon
Increased Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Pseudophakic Corneal Edema
Invest. Ophthalmol. Vis. Sci., June 1, 2005; 46(6): 1940 - 1947.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Mahmoodi, S. Sahebjam, D. Smookler, R. Khokha, and J. S. Mort
Lack of Tissue Inhibitor of Metalloproteinases-3 Results in an Enhanced Inflammatory Response in Antigen-Induced Arthritis
Am. J. Pathol., June 1, 2005; 166(6): 1733 - 1740.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. K. Chang and J. LoCicero III
Overexpressed nuclear factor {kappa}B correlates with enhanced expression of interleukin-1{beta} and inducible nitric oxide synthase in aged murine lungs to endotoxic stress
Ann. Thorac. Surg., April 1, 2004; 77(4): 1222 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. B. Buchanan, E. Peloso, and E. Satinoff
Thermoregulatory and metabolic changes during fever in young and old rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1165 - R1169.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
K. Sharman, E. Sharman, A. Campbell, and S. C. Bondy
Reduced Basal Levels and Enhanced LPS Response of IL-6 mRNA in Aged Mice
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2001; 56(12): B520 - 523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Florez-Duquet, E. Peloso, and E. Satinoff
Fever and behavioral thermoregulation in young and old rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1457 - R1461.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
K. S. Krabbe, H. Bruunsgaard, C. M. Hansen, K. Moller, L. Fonsmark, J. Qvist, P. L. Madsen, G. Kronborg, H. O. Andersen, P. Skinhoj, et al.
Ageing Is Associated with a Prolonged Fever Response in Human Endotoxemia
Clin. Vaccine Immunol., March 1, 2001; 8(2): 333 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Z.-q. Yan, A. Sirsjo, M.-L. Bochaton-Piallat, G. Gabbiani, and G. K. Hansson
Augmented Expression of Inducible NO Synthase in Vascular Smooth Muscle Cells During Aging Is Associated With Enhanced NF-{kappa}B Activation
Arterioscler. Thromb. Vasc. Biol., December 1, 1999; 19(12): 2854 - 2862.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M.-C. Farges, M.-P. Bérard, F. Raul, J.-P. Cézard, B. Joly, P. Davot, M.-P. Vasson, and L. Cynober
Oral Administration of a Glutamine-Enriched Diet Before or After Endotoxin Challenge in Aged Rats Has Limited Effects
J. Nutr., October 1, 1999; 129(10): 1799 - 1806.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
M. E. Poynter and R. A. Daynes
Peroxisome Proliferator-activated Receptor alpha  Activation Modulates Cellular Redox Status, Represses Nuclear Factor-kappa B Signaling, and Reduces Inflammatory Cytokine Production in Aging
J. Biol. Chem., December 4, 1998; 273(49): 32833 - 32841.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Paolisso, M. R. Rizzo, G. Mazziotti, M. R. Tagliamonte, A. Gambardella, M. Rotondi, C. Carella, D. Giugliano, M. Varricchio, and F. D'Onofrio
Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha
Am J Physiol Endocrinol Metab, August 1, 1998; 275(2): E294 - E299.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Saito and J. Papaconstantinou
Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress
J. Biol. Chem., July 27, 2001; 276(31): 29307 - 29312.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.