| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 156, Issue 4 1515-1524, Copyright © 1996 by American Association of Immunologists
ARTICLES |
ME Berman, Y Xie and WA Muller
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA.
Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a glycoprotein expressed on the surfaces of monocytes, neutrophils, platelets, a subpopulation of T cells, and, as described in this work, on NK cells. It is also concentrated at the junctions between endothelial cells (EC) in culture, and is expressed on continuous endothelia in all tissues. PECAM has been shown to be involved in monocyte and neutrophil transendothelial migration in vitro and in vivo. The function of PECAM in NK cell interaction with EC has never been studied. In this work, we demonstrate that ligation of PECAM on the surface of NK cells activates their beta 2 integrins. Anti-PECAM Abs added to NK cells caused a 2.5- to 4-fold increase in the binding of these cells to monolayers of EC or 3T3 cells transfected with ICAM- 1, and this was inhibited by a mAb against CD18. PECAM also plays a role in NK cell transendothelial migration. Anti-PECAM Abs inhibited 50% of NK cell transmigration through resting EC in an in vitro system. The transmigration of CD56dim and CD56bright cells was inhibited equally. IFN-gamma increased NK cell transmigration; the transmigration of CD56bright cells was increased to a much greater extent than CD56dim transmigration (4-fold vs 1.5-fold). Anti-PECAM inhibited the transmigration of CD56dim cells by 30%, while that of CD56bright cells was not blocked. These studies demonstrate that PECAM-1 could play an important role in the extravasation of NK cells into tissues for constitutive surveillance and into sites of inflammation.
This article has been cited by other articles:
|
|
 |
|
  A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS J. Leukoc. Biol., July 1, 2008; 84(1): 1 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bergom, C. Paddock, C. Gao, T. Holyst, D. K. Newman, and P. J. Newman An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling J. Cell Sci., April 15, 2008; 121(8): 1235 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Woodfin, M.-B. Voisin, and S. Nourshargh PECAM-1: A Multi-Functional Molecule in Inflammation and Vascular Biology Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2514 - 2523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rijcken, R. B. Mennigen, S. D. Schaefer, M. G. Laukoetter, C. Anthoni, H.-U. Spiegel, M. Bruewer, N. Senninger, and C. F. Krieglstein PECAM-1 (CD 31) mediates transendothelial leukocyte migration in experimental colitis Am J Physiol Gastrointest Liver Physiol, August 1, 2007; 293(2): G446 - G452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. OUYANG, G. BAERLOCHER, I. VULTO, and P. M. LANSDORP Telomere Length in Human Natural Killer Cell Subsets Ann. N.Y. Acad. Sci., June 1, 2007; 1106(1): 240 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kondo, E. A. Scheef, N. Sheibani, and C. M. Sorenson PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2070 - C2083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Lou, P. Alcaide, F. W. Luscinskas, and W. A. Muller CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils J. Immunol., January 15, 2007; 178(2): 1136 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Bentz, M. Jarquin-Pardo, G. Chan, M. S. Smith, C. Sinzger, and A. D. Yurochko Human Cytomegalovirus (HCMV) Infection of Endothelial Cells Promotes Naive Monocyte Extravasation and Transfer of Productive Virus To Enhance Hematogenous Dissemination of HCMV J. Virol., December 1, 2006; 80(23): 11539 - 11555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Eugenin, R. Gamss, C. Buckner, D. Buono, R. S. Klein, E. E. Schoenbaum, T. M. Calderon, and J. W. Berman Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS. J. Leukoc. Biol., March 1, 2006; 79(3): 444 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Falati, S. Patil, P. L. Gross, M. Stapleton, G. Merrill-Skoloff, N. E. Barrett, K. L. Pixton, H. Weiler, B. Cooley, D. K. Newman, et al. Platelet PECAM-1 inhibits thrombus formation in vivo Blood, January 15, 2006; 107(2): 535 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Wee and D. E. Jackson The Ig-ITIM superfamily member PECAM-1 regulates the "outside-in" signaling properties of integrin {alpha}IIb{beta}3 in platelets Blood, December 1, 2005; 106(12): 3816 - 3823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Lomakina and R. E. Waugh Micromechanical Tests of Adhesion Dynamics between Neutrophils and Immobilized ICAM-1 Biophys. J., February 1, 2004; 86(2): 1223 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gao, W. Sun, M. Christofidou-Solomidou, M. Sawada, D. K. Newman, C. Bergom, S. M. Albelda, S. Matsuyama, and P. J. Newman PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis Blood, July 1, 2003; 102(1): 169 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Newman and D. K. Newman Signal Transduction Pathways Mediated by PECAM-1: New Roles for an Old Molecule in Platelet and Vascular Cell Biology Arterioscler. Thromb. Vasc. Biol., June 1, 2003; 23(6): 953 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Randolph, G. Sanchez-Schmitz, R. M. Liebman, and K. Schakel The CD16+ (Fc{gamma}RIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting J. Exp. Med., August 19, 2002; 196(4): 517 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Lalor, S. Edwards, G. McNab, M. Salmi, S. Jalkanen, and D. H. Adams Vascular Adhesion Protein-1 Mediates Adhesion and Transmigration of Lymphocytes on Human Hepatic Endothelial Cells J. Immunol., July 15, 2002; 169(2): 983 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miller, K.-L. P. Sung, W. A. Muller, J. Y. Cho, M. Roman, D. Castaneda, J. Nayar, T. Condon, J. Kim, P. Sriramarao, et al. Eosinophil Tissue Recruitment to Sites of Allergic Inflammation in the Lung Is Platelet Endothelial Cell Adhesion Molecule Independent J. Immunol., August 15, 2001; 167(4): 2292 - 2297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Zhao and P. J. Newman Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 from Within the Cell J. Cell Biol., January 8, 2001; 152(1): 65 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zeng, L. Gao, S. Birklé, and R. K. Yu Suppression of Ganglioside GD3 Expression in a Rat F-11 Tumor Cell Line Reduces Tumor Growth, Angiogenesis, and Vascular Endothelial Growth Factor Production Cancer Res., December 1, 2000; 60(23): 6670 - 6676. [Abstract] [Full Text]
|
|
|
|
|
|
F. P. J. Mul, A. E. M. Zuurbier, H. Janssen, J. Calafat, S. van Wetering, P. S. Hiemstra, D. Roos, and P. L. Hordijk Sequential migration of neutrophils across monolayers of endothelial and epithelial cells J. Leukoc. Biol., October 1, 2000; 68(4): 529 - 537. [Abstract] [Full Text]
|
|
|
|
|
|
D. Sanmugalingam, A. J. Wardlaw, and P. Bradding Adhesion of human lung mast cells to bronchial epithelium: evidence for a novel carbohydrate-mediated mechanism J. Leukoc. Biol., July 1, 2000; 68(1): 38 - 46. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Casey, P.A.W. Rogers, and B.J. Vollenhoven An immunohistochemical analysis of fibroid vasculature Hum. Reprod., July 1, 2000; 15(7): 1469 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Reedquist, E. Ross, E. A. Koop, R. M.F. Wolthuis, F. J.T. Zwartkruis, Y. van Kooyk, M. Salmon, C. D. Buckley, and J. L. Bos The Small GTPase, Rap1, Mediates CD31-induced Integrin Adhesion J. Cell Biol., March 20, 2000; 148(6): 1151 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Johnson-Leger, M Aurrand-Lions, and B. Imhof The parting of the endothelium: miracle, or simply a junctional affair? J. Cell Sci., January 3, 2000; 113(6): 921 - 933. [Abstract] [PDF]
|
|
|
|
|
|
F. Liao, A. R. Schenkel, and W. A. Muller Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes J. Immunol., November 15, 1999; 163(10): 5640 - 5648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wiedle, C. Johnson-Leger, and B. A. Imhof A Chimeric Cell Adhesion Molecule Mediates Homing of Lymphocytes to Vascularized Tumors Cancer Res., October 1, 1999; 59(20): 5255 - 5263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chiba, N. Nakagawa, K. Kurasawa, Y. Tanaka, Y. Saito, and I. Iwamoto Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells Blood, August 15, 1999; 94(4): 1319 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Redick and V. L. Bautch Developmental Platelet Endothelial Cell Adhesion Molecule Expression Suggests Multiple Roles for a Vascular Adhesion Molecule Am. J. Pathol., April 1, 1999; 154(4): 1137 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-i. Masuyama, T. Yoshio, K. Suzuki, S. Kitagawa, M. Iwamoto, T. Kamimura, D. Hirata, A. Takeda, S. Kano, and S. Minota Characterization of the 4C8 Antigen Involved in Transendothelial Migration of CD26hi T Cells after Tight Adhesion to Human Umbilical Vein Endothelial Cell Monolayers J. Exp. Med., March 15, 1999; 189(6): 979 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Quarmby, P. Kumar, J. Wang, J. A. Macro, J. J. Hutchinson, R. D. Hunter, and S. Kumar Irradiation Induces Upregulation of CD31 in Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 588 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Duncan, D. P. Andrew, H. Takimoto, S. A. Kaufman, H. Yoshida, J. Spellberg, J. Luis de la Pompa, A. Elia, A. Wakeham, B. Karan-Tamir, et al. Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions J. Immunol., March 1, 1999; 162(5): 3022 - 3030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Frey, N. B. Packianathan, T. A. Fehniger, M. E. Ross, W.-C. Wang, C. C. Stewart, M. A. Caligiuri, and S. S. Evans Differential Expression and Function of L-Selectin on CD56bright and CD56dim Natural Killer Cell Subsets J. Immunol., July 1, 1998; 161(1): 400 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-H. Sun, C. Paddock, G. P. Visentin, M. M. Zukowski, W. A. Muller, and P. J. Newman Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1. PECAM-1 IS NOT A HEPARIN-BINDING PROTEIN J. Biol. Chem., May 8, 1998; 273(19): 11483 - 11490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Wang, L. M. Goldman, D. M. Schleider, M. M. Appenheimer, J. R. Subjeck, E. A. Repasky, and S. S. Evans Fever-Range Hyperthermia Enhances L-Selectin-Dependent Adhesion of Lymphocytes to Vascular Endothelium J. Immunol., January 15, 1998; 160(2): 961 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets Blood, January 15, 1998; 91(2): 500 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sagawa, T. Kimura, M. Swieter, and R. P. Siraganian The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31) J. Biol. Chem., December 5, 1997; 272(49): 31086 - 31091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Litwin, K. Clark, L. Noack, J. Furze, M. Berndt, S. Albelda, M. Vadas, and J. Gamble Novel Cytokine-independent Induction of Endothelial Adhesion Molecules Regulated by Platelet/Endothelial Cell Adhesion Molecule (CD31) J. Cell Biol., October 6, 1997; 139(1): 219 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Jackson, K. R. Kupcho, and Peter. J. Newman Characterization of Phosphotyrosine Binding Motifs in the Cytoplasmic Domain of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Are Required for the Cellular Association and Activation of the Protein-tyrosine Phosphatase, SHP-2 J. Biol. Chem., October 3, 1997; 272(40): 24868 - 24875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. Lu, M. Barreuther, S. Davis, and J. A. Madri Platelet Endothelial Cell Adhesion Molecule-1 Is Phosphorylatable by c-Src, Binds Src-Src homology 2 Domain, and Exhibits Immunoreceptor Tyrosine-based Activation Motif-like Properties J. Biol. Chem., May 30, 1997; 272(22): 14442 - 14446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liao, J. Ali, T. Greene, and W. A. Muller Soluble Domain 1 of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo J. Exp. Med., April 7, 1997; 185(7): 1349 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Jackson, C. M. Ward, R. Wang, and P. J. Newman The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation. EVIDENCE FOR A MECHANISTIC LINK BETWEEN PECAM-1- AND INTEGRIN-MEDIATED CELLULAR SIGNALING J. Biol. Chem., March 14, 1997; 272(11): 6986 - 6993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Sandig, E Negrou, and K. Rogers Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture J. Cell Sci., January 11, 1997; 110(22): 2807 - 2818. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Andre, O. Spertini, S. Guia, P. Rihet, F. Dignat-George, H. Brailly, J. Sampol, P. J. Anderson, and E. Vivier Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin PNAS, March 28, 2000; 97(7): 3400 - 3405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cao, C. D. O'Brien, Z. Zhou, S. M. Sanders, J. N. Greenbaum, A. Makrigiannakis, and H. M. DeLisser Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1181 - C1190. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
