The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by VanCott, J. L.
Right arrow Articles by McGhee, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by VanCott, J. L.
Right arrow Articles by McGhee, J. R.

The Journal of Immunology, Vol 156, Issue 4 1504-1514, Copyright © 1996 by American Association of Immunologists

ARTICLES

Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella

JL VanCott, HF Staats, DW Pascual, M Roberts, SN Chatfield, M Yamamoto, M Coste, PB Carter, H Kiyono and JR McGhee
Immunobiology Vaccine Center, University of Alabama Medical Center, Birmingham 35294, USA.

We have assessed regulatory Th cell and cytokine responses in mice after oral immunization with recombinant Salmonella (BRD 847) expressing fragment C of tetanus toxoid, since little information is available to explain how these vectors induce mucosal IgA responses. A single dose of BRD 847 elicited serum IgG2a and mucosal IgA anti- tetanus toxoid Ab responses. To assess Th1-and Th2-type responses, CD4+ T cells from Peyer's patches and spleen were restimulated in vitro, and cytokine-specific ELISPOT, ELISA, and reverse transcriptase-PCR assays were used to assess cytokine patterns. CD4+ T cells produced IFN-gamma and IL-2 as well as IL-10, but not IL-4 or IL-5. Although IL-6 was elevated, further purification of cells from in vitro cultures into CD4+ Mac-1- T cells and Mac-1+ CD4- cells revealed that only the latter cell population had consistently elevated IL-6 gene expression, whereas both sorted populations exhibited increased IFN-gamma and IL-10 gene expression. Thus, orally administered recombinant Salmonella expressing fragment C of tetanus toxoid elicited dominant Ag-specific Th1-type responses together with Th2-type cells producing IL-10 in both mucosal and systemic tissues. Macrophages producing IL-6 were also evident. Our results are consistent with the suggestion that Ag-specific Th1 cells and their derived cytokines, IFN-gamma and IL-2, and Th2-derived IL-10 together with IL-6 produced by macrophages provide important signals for the development of mucosal IgA and serum IgG subclass responses in the absence of preferential expression of Th2 cytokines IL-4 and IL-5.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
J. Ochoa-Reparaz, A. Rynda, M. A. Ascon, X. Yang, I. Kochetkova, C. Riccardi, G. Callis, T. Trunkle, and D. W. Pascual
IL-13 Production by Regulatory T Cells Protects against Experimental Autoimmune Encephalomyelitis Independently of Autoantigen
J. Immunol., July 15, 2008; 181(2): 954 - 968.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. Momoi, T. Hashizume, T. Kurita-Ochiai, Y. Yuki, H. Kiyono, and M. Yamamoto
Nasal Vaccination with the 40-Kilodalton Outer Membrane Protein of Porphyromonas gingivalis and a Nontoxic Chimeric Enterotoxin Adjuvant Induces Long-Term Protective Immunity with Reduced Levels of Immunoglobulin E Antibodies
Infect. Immun., June 1, 2008; 76(6): 2777 - 2784.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Hashizume, A. Togawa, T. Nochi, O. Igarashi, M.-N. Kweon, H. Kiyono, and M. Yamamoto
Peyer's Patches Are Required for Intestinal Immunoglobulin A Responses to Salmonella spp.
Infect. Immun., March 1, 2008; 76(3): 927 - 934.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
F. W. van Ginkel, T. Iwamoto, B. D. Schultz, and J. M. Tomich
Immunity to a Self-Derived, Channel-Forming Peptide in the Respiratory Tract
Clin. Vaccine Immunol., February 1, 2008; 15(2): 260 - 266.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
G. C. Ippolito, R. L. Schelonka, M. Zemlin, I. I. Ivanov, R. Kobayashi, C. Zemlin, G. L. Gartland, L. Nitschke, J. Pelkonen, K. Fujihashi, et al.
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
J. Exp. Med., June 12, 2006; 203(6): 1567 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Palaniappan, S. Singh, U. P. Singh, R. Singh, E. W. Ades, D. E. Briles, S. K. Hollingshead, W. Royal III, J. S. Sampson, J. K. Stiles, et al.
CCL5 Modulates Pneumococcal Immunity and Carriage
J. Immunol., February 15, 2006; 176(4): 2346 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Jun, W. Gilmore, G. Callis, A. Rynda, A. Haddad, and D. W. Pascual
A Live Diarrheal Vaccine Imprints a Th2 Cell Bias and Acts as an Anti-Inflammatory Vaccine
J. Immunol., November 15, 2005; 175(10): 6733 - 6740.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. A. Ascon, J. Ochoa-Reparaz, N. Walters, and D. W. Pascual
Partially Assembled K99 Fimbriae Are Required for Protection
Infect. Immun., November 1, 2005; 73(11): 7274 - 7280.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Ohmura, M. Yamamoto, C. Tomiyama-Miyaji, Y. Yuki, Y. Takeda, and H. Kiyono
Nontoxic Shiga Toxin Derivatives from Escherichia coli Possess Adjuvant Activity for the Augmentation of Antigen-Specific Immune Responses via Dendritic Cell Activation
Infect. Immun., July 1, 2005; 73(7): 4088 - 4097.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Walters, T. Trunkle, M. Sura, and D. W. Pascual
Enhanced Immunoglobulin A Response and Protection against Salmonella enterica Serovar Typhimurium in the Absence of the Substance P Receptor
Infect. Immun., January 1, 2005; 73(1): 317 - 324.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
U. P. Singh, S. Singh, P. N. Boyaka, J. R. McGhee, and J. W. Lillard Jr
Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8R{beta} interactions
J. Leukoc. Biol., December 1, 2004; 76(6): 1240 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. O. Lasaro, W. B. Luiz, M. E. Sbrogio-Almeida, L. S. Nishimura, B. E. C. Guth, and L. C. S. Ferreira
Combined Vaccine Regimen Based on Parenteral Priming with a DNA Vaccine and Administration of an Oral Booster Consisting of a Recombinant Salmonella enterica Serovar Typhimurium Vaccine Strain for Immunization against Infection with Human-Derived Enterotoxigenic Escherichia coli Strains
Infect. Immun., November 1, 2004; 72(11): 6480 - 6491.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. P. Singh, S. Singh, P. Ravichandran, D. D. Taub, and J. W. Lillard Jr.
Viral Macrophage-Inflammatory Protein-II: A Viral Chemokine That Differentially Affects Adaptive Mucosal Immunity Compared with Its Mammalian Counterparts
J. Immunol., November 1, 2004; 173(9): 5509 - 5516.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Robinson, L. M. Chamberlain, M. C. Lopez, C. M. Rush, H. Marcotte, R. W. F. Le Page, and J. M. Wells
Mucosal and Cellular Immune Responses Elicited by Recombinant Lactococcus lactis Strains Expressing Tetanus Toxin Fragment C
Infect. Immun., May 1, 2004; 72(5): 2753 - 2761.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kataoka, J. R. McGhee, R. Kobayashi, K. Fujihashi, S. Shizukuishi, and K. Fujihashi
Nasal Flt3 Ligand cDNA Elicits CD11c+CD8+ Dendritic Cells for Enhanced Mucosal Immunity
J. Immunol., March 15, 2004; 172(6): 3612 - 3619.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. Chen and D. M. Schifferli
Construction, Characterization, and Immunogenicity of an Attenuated Salmonella enterica Serovar Typhimurium pgtE Vaccine Expressing Fimbriae with Integrated Viral Epitopes from the spiC Promoter
Infect. Immun., August 1, 2003; 71(8): 4664 - 4673.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. W. Lillard Jr, U. P. Singh, P. N. Boyaka, S. Singh, D. D. Taub, and J. R. McGhee
MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity
Blood, February 1, 2003; 101(3): 807 - 814.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. N. Boyaka, M. Ohmura, K. Fujihashi, T. Koga, M. Yamamoto, M.-N. Kweon, Y. Takeda, R. J. Jackson, H. Kiyono, Y. Yuki, et al.
Chimeras of Labile Toxin One and Cholera Toxin Retain Mucosal Adjuvanticity and Direct Th Cell Subsets Via Their B Subunit
J. Immunol., January 1, 2003; 170(1): 454 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. F. Hoft and C. S. Eickhoff
Type 1 Immunity Provides Optimal Protection against Both Mucosal and Systemic Trypanosoma cruzi Challenges
Infect. Immun., December 1, 2002; 70(12): 6715 - 6725.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Q.-B. Yang, M. Martin, S. M. Michalek, and J. Katz
Mechanisms of Monophosphoryl Lipid A Augmentation of Host Responses to Recombinant HagB from Porphyromonas gingivalis
Infect. Immun., July 1, 2002; 70(7): 3557 - 3565.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. J. Pestka, H.-R. Zhou, Q. Jia, and A. M. Timmer
Dietary Fish Oil Suppresses Experimental Immunoglobulin A Nephropathy in Mice
J. Nutr., February 1, 2002; 132(2): 261 - 269.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Jespersgaard, P. Zhang, G. Hajishengallis, M. W. Russell, and S. M. Michalek
Effect of Attenuated Salmonella enterica Serovar Typhimurium Expressing a Streptococcus mutans Antigen on Secondary Responses to the Cloned Protein
Infect. Immun., November 1, 2001; 69(11): 6604 - 6611.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
U. Yrlid, M. Svensson, A. Hakansson, B. J. Chambers, H.-G. Ljunggren, and M. J. Wick
In Vivo Activation of Dendritic Cells and T Cells during Salmonella enterica Serovar Typhimurium Infection
Infect. Immun., September 1, 2001; 69(9): 5726 - 5735.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Dohi, P. D. Rennert, K. Fujihashi, H. Kiyono, Y. Shirai, Y. I. Kawamura, J. L. Browning, and J. R. McGhee
Elimination of Colonic Patches with Lymphotoxin {beta} Receptor-Ig Prevents Th2 Cell-Type Colitis
J. Immunol., September 1, 2001; 167(5): 2781 - 2790.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Wu, X. Wang, K. L. Csencsits, A. Haddad, N. Walters, and D. W. Pascual
M cell-targeted DNA vaccination
PNAS, July 13, 2001; (2001) 161204098.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. W. Pascual, M. D. White, T. Larson, and N. Walters
Impaired Mucosal Immunity in L-Selectin-Deficient Mice Orally Immunized with a Salmonella Vaccine Vector
J. Immunol., July 1, 2001; 167(1): 407 - 415.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y. Huang, G. Hajishengallis, and S. M. Michalek
Induction of Protective Immunity against Streptococcus mutans Colonization after Mucosal Immunization with Attenuated Salmonella enterica Serovar Typhimurium Expressing an S. mutans Adhesin under the Control of In Vivo-Inducible nirB Promoter
Infect. Immun., April 1, 2001; 69(4): 2154 - 2161.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Grangette, H. Muller-Alouf, D. Goudercourt, M.-C. Geoffroy, M. Turneer, and A. Mercenier
Mucosal Immune Responses and Protection against Tetanus Toxin after Intranasal Immunization with Recombinant Lactobacillus plantarum
Infect. Immun., March 1, 2001; 69(3): 1547 - 1553.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Lucas, D. Bumann, A. Walduck, J. Koesling, L. Develioglu, T. F. Meyer, and T. Aebischer
Adoptive Transfer of CD4+ T Cells Specific for Subunit A of Helicobacter pylori Urease Reduces H. pylori Stomach Colonization in Mice in the Absence of Interleukin-4 (IL-4)/IL-13 Receptor Signaling
Infect. Immun., March 1, 2001; 69(3): 1714 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. U. Igietseme, J. L. Portis, and L. L. Perry
Inflammation and Clearance of Chlamydia trachomatis in Enteric and Nonenteric Mucosae
Infect. Immun., March 1, 2001; 69(3): 1832 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. N. Boyaka, M. Marinaro, R. J. Jackson, F. W. van Ginkel, E. Cormet-Boyaka, K. L. Kirk, C. R. Kensil, and J. R. McGhee
Oral QS-21 Requires Early IL-4 Help for Induction of Mucosal and Systemic Immunity
J. Immunol., February 15, 2001; 166(4): 2283 - 2290.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Lillard Jr., P. N. Boyaka, D. D. Taub, and J. R. McGhee
RANTES Potentiates Antigen-Specific Mucosal Immune Responses
J. Immunol., January 1, 2001; 166(1): 162 - 169.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Elhofy, I. Marriott, and K. L. Bost
Salmonella Infection Does Not Increase Expression and Activity of the High Affinity IL-12 Receptor
J. Immunol., September 15, 2000; 165(6): 3324 - 3332.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. C. R. Guillobel, J. I. Carinhanha, L. Cardenas, J. D. Clements, D. F. de Almeida, and L. C. S. Ferreira
Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a Live Salmonella enterica Serovar Typhimurium Vaccine Strain
Infect. Immun., July 1, 2000; 68(7): 4349 - 4353.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. L. VanCott, M. A. Franco, H. B. Greenberg, S. Sabbaj, B. Tang, R. Murray, and J. R. McGhee
Protective Immunity to Rotavirus Shedding in the Absence of Interleukin-6: Th1 Cells and Immunoglobulin A Develop Normally
J. Virol., June 1, 2000; 74(11): 5250 - 5256.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. Yamamoto, P. Rennert, J. R. McGhee, M.-N. Kweon, S. Yamamoto, T. Dohi, S. Otake, H. Bluethmann, K. Fujihashi, and H. Kiyono
Alternate Mucosal Immune System: Organized Peyer's Patches Are Not Required for IgA Responses in the Gastrointestinal Tract
J. Immunol., May 15, 2000; 164(10): 5184 - 5191.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Sydenham, G. Douce, F. Bowe, S. Ahmed, S. Chatfield, and G. Dougan
Salmonella enterica Serovar Typhimurium surA Mutants Are Attenuated and Effective Live Oral Vaccines
Infect. Immun., March 1, 2000; 68(3): 1109 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. W. Pascual, D. M. Hone, S. Hall, F. W. van Ginkel, M. Yamamoto, N. Walters, K. Fujihashi, R. J. Powell, S. Wu, J. L. Vancott, et al.
Expression of Recombinant Enterotoxigenic Escherichia coli Colonization Factor Antigen I by Salmonella typhimurium Elicits a Biphasic T Helper Cell Response
Infect. Immun., December 1, 1999; 67(12): 6249 - 6256.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Katz, K. P. Black, and S. M. Michalek
Host Responses to Recombinant Hemagglutinin B of Porphyromonas gingivalis in an Experimental Rat Model
Infect. Immun., September 1, 1999; 67(9): 4352 - 4359.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. W. v. Ginkel, S. M. Wahl, J. F. Kearney, M.-N. Kweon, K. Fujihashi, P. D. Burrows, H. Kiyono, and J. R. McGhee
Partial IgA-Deficiency with Increased Th2-Type Cytokines in TGF-{beta}1 Knockout Mice
J. Immunol., August 15, 1999; 163(4): 1951 - 1957.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Benyacoub, S. Hopkins, A. Potts, S. Kelly, J.-P. Kraehenbuhl, R. Curtiss III, P. De Grandi, and D. Nardelli-Haefliger
The Nature of the Attenuation of Salmonella typhimurium Strains Expressing Human Papillomavirus Type 16 Virus-Like Particles Determines the Systemic and Mucosal Antibody Responses in Nasally Immunized Mice
Infect. Immun., July 1, 1999; 67(7): 3674 - 3679.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J.-F. Viret, D. Favre, B. Wegmuller, C. Herzog, J. U. Que, S. J. Cryz Jr., and A. B. Lang
Mucosal and Systemic Immune Responses in Humans after Primary and Booster Immunizations with Orally Administered Invasive and Noninvasive Live Attenuated Bacteria
Infect. Immun., July 1, 1999; 67(7): 3680 - 3685.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Yamamoto, H. Kiyono, S. Yamamoto, E. Batanero, M.-N. Kweon, S. Otake, M. Azuma, Y. Takeda, and J. R. McGhee
Direct Effects on Antigen-Presenting Cells and T Lymphocytes Explain the Adjuvanticity of a Nontoxic Cholera Toxin Mutant
J. Immunol., June 15, 1999; 162(12): 7015 - 7021.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. Everest, J. Ketley, S. Hardy, G. Douce, S. Khan, J. Shea, D. Holden, D. Maskell, and G. Dougan
Evaluation of Salmonella typhimurium Mutants in a Model of Experimental Gastroenteritis
Infect. Immun., June 1, 1999; 67(6): 2815 - 2821.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
T. Dohi, K. Fujihashi, P. D. Rennert, K. Iwatani, H. Kiyono, and J. R. McGhee
Hapten-induced Colitis Is Associated with Colonic Patch Hypertrophy and T Helper Cell 2-Type Responses
J. Exp. Med., April 19, 1999; 189(8): 1169 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Zhang, X. Yang, H. Lu, G. Zhong, and R. C. Brunham
Immunity to Chlamydia trachomatis Mouse Pneumonitis Induced by Vaccination with Live Organisms Correlates with Early Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-12 Production and with Dendritic Cell-Like Maturation
Infect. Immun., April 1, 1999; 67(4): 1606 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Lillard Jr., P. N. Boyaka, J. A. Hedrick, A. Zlotnik, and J. R. McGhee
Lymphotactin Acts as an Innate Mucosal Adjuvant
J. Immunol., February 15, 1999; 162(4): 1959 - 1965.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. W. Lillard Jr., P. N. Boyaka, O. Chertov, J. J. Oppenheim, and J. R. McGhee
Mechanisms for induction of acquired host immunity by neutrophil peptide defensins
PNAS, January 19, 1999; 96(2): 651 - 656.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. N. Boyaka, M. Marinaro, R. J. Jackson, S. Menon, H. Kiyono, E. Jirillo, and J. R. McGhee
IL-12 Is an Effective Adjuvant for Induction of Mucosal Immunity
J. Immunol., January 1, 1999; 162(1): 122 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. G. Schwacha, J. J. Meissler Jr., and T. K. Eisenstein
Salmonella typhimurium Infection in Mice Induces Nitric Oxide-Mediated Immunosuppression through a Natural Killer Cell-Dependent Pathway
Infect. Immun., December 1, 1998; 66(12): 5862 - 5866.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. A. Ascon, D. M. Hone, N. Walters, and D. W. Pascual
Oral Immunization with a Salmonella typhimurium Vaccine Vector Expressing Recombinant Enterotoxigenic Escherichia coli K99 Fimbriae Elicits Elevated Antibody Titers for Protective Immunity
Infect. Immun., November 1, 1998; 66(11): 5470 - 5476.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Yamamoto, D. E. Briles, S. Yamamoto, M. Ohmura, H. Kiyono, and J. R. McGhee
A Nontoxic Adjuvant for Mucosal Immunity to Pneumococcal Surface Protein A
J. Immunol., October 15, 1998; 161(8): 4115 - 4121.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Roberts, J. Li, A. Bacon, and S. Chatfield
Oral Vaccination against Tetanus: Comparison of the Immunogenicities of Salmonella Strains Expressing Fragment C from the nirB and htrA Promoters
Infect. Immun., July 1, 1998; 66(7): 3080 - 3087.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. W. Pascual, N. Walters, and P. Hillemeyer
Repeated Intratracheal Instillations of Nonreplicating Adenovirus 2 Vector Attenuate CTL Responses and IFN-{gamma} Production
J. Immunol., May 1, 1998; 160(9): 4465 - 4472.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-N. Kweon, K. Fujihashi, J. L. VanCott, K. Higuchi, M. Yamamoto, J. R. McGhee, and H. Kiyono
Lack of Orally Induced Systemic Unresponsiveness in IFN-{gamma} Knockout Mice
J. Immunol., February 15, 1998; 160(4): 1687 - 1693.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. C. VanCott, R. W. Kaminski, J. R. Mascola, V. S. Kalyanaraman, N. M. Wassef, C. R. Alving, J.T. Ulrich, G. H. Lowell, and D. L. Birx
HIV-1 Neutralizing Antibodies in the Genital and Respiratory Tracts of Mice Intranasally Immunized with Oligomeric gp160
J. Immunol., February 15, 1998; 160(4): 2000 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
I. E. Corthesy-Theulaz, S. Hopkins, D. Bachmann, P. F. Saldinger, N. Porta, R. Haas, Y. Zheng-Xin, T. Meyer, H. Bouzourene, A. L. Blum, et al.
Mice Are Protected from Helicobacter pylori Infection by Nasal Immunization with Attenuated Salmonella typhimurium phoPc Expressing Urease A and B Subunits
Infect. Immun., February 1, 1998; 66(2): 581 - 586.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. J. Dunstan, C. P. Simmons, and R. A. Strugnell
Comparison of the Abilities of Different Attenuated Salmonella typhimurium Strains To Elicit Humoral Immune Responses against a Heterologous Antigen
Infect. Immun., February 1, 1998; 66(2): 732 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. A. Benton, J. L. VanCott, and D. E. Briles
Role of Tumor Necrosis Factor Alpha in the Host Response of Mice to Bacteremia Caused by Pneumolysin-Deficient Streptococcus pneumoniae
Infect. Immun., February 1, 1998; 66(2): 839 - 842.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Yamamoto, H. Kiyono, M. Yamamoto, K. Imaoka, M. Yamamoto, K. Fujihashi, F. W. Van Ginkel, M. Noda, Y. Takeda, and J. R. McGhee
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity
PNAS, May 13, 1997; 94(10): 5267 - 5272.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Wu, X. Wang,