| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 156, Issue 3 1110-1116, Copyright © 1996 by American Association of Immunologists
ARTICLES |
S Kanangat, J Thomas, S Gangappa, JS Babu and BT Rouse
Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37996, USA.
In this report we investigated whether induction of IL-12 occurs in response to herpes simplex virus (HSV) infection of the mouse eye, which may serve to regulate the nature of the subsequent immune response. The data show early induction and continued maintenance of IL- 12 (p40) mRNA in the cornea and draining lymph node upon ocular infection with HSV. Using a very sensitive radioimmunoassay technique, IL-12 (p40) protein also was detected in the cornea upon ocular HSV infection. Unfractionated splenocytes and enriched populations of dendritic cells, macrophages, and neutrophils all responded to HSV infection in vitro by up-regulating the expression of IL-12 (p40) mRNA. However, cultured corneal cells failed to generate IL-12 (p40) upon exposure to HSV. The data indicate that inflammatory cells that infiltrate the cornea in response to HSV-1 infection are the main source of IL-12 in the eye. Our results are consistent with the hypothesis that IL-12 induction in the eye acts as a triggering event that biases HSV-specific immunity to a type 1 T cell response, which, in the environment of the eye, culminates in an immunopathologic disease.
This article has been cited by other articles:
|
|
 |
|
  P. C. Reading, P. G. Whitney, D. P. Barr, M. Wojtasiak, J. D. Mintern, J. Waithman, and A. G. Brooks IL-18, but not IL-12, Regulates NK Cell Activity following Intranasal Herpes Simplex Virus Type 1 Infection J. Immunol., September 1, 2007; 179(5): 3214 - 3221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Jones, M. Fernandez, K. Herc, L. Bosnjak, M. Miranda-Saksena, R. A. Boadle, and A. Cunningham Herpes Simplex Virus Type 2 Induces Rapid Cell Death and Functional Impairment of Murine Dendritic Cells In Vitro J. Virol., October 15, 2003; 77(20): 11139 - 11149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Gherardi, J. C. Ramirez, and M. Esteban IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system J. Gen. Virol., August 1, 2003; 84(8): 1961 - 1972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Kumaraguru and B. T. Rouse The IL-12 response to herpes simplex virus is mainly a paracrine response of reactive inflammatory cells J. Leukoc. Biol., September 1, 2002; 72(3): 564 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Stumpf, R. Case, C. Shimeld, D. L. Easty, and T. J. Hill Primary herpes simplex virus type 1 infection of the eye triggers similar immune responses in the cornea and the skin of the eyelids J. Gen. Virol., June 1, 2002; 83(7): 1579 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Ali, J. Lynam, C. S. McLean, C. Entwisle, P. Loudon, J. M. Rojas, S. E. B. McArdle, G. Li, S. Mian, and R. C. Rees Tumor Regression Induced by Intratumor Therapy with a Disabled Infectious Single Cycle (DISC) Herpes Simplex Virus (HSV) Vector, DISC/HSV/Murine Granulocyte-Macrophage Colony-Stimulating Factor, Correlates with Antigen-Specific Adaptive Immunity J. Immunol., April 1, 2002; 168(7): 3512 - 3519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee, M. Zheng, S. Deshpande, S. K. Eo, T. A. Hamilton, and B. T. Rouse IL-12 suppresses the expression of ocular immunoinflammatory lesions by effects on angiogenesis J. Leukoc. Biol., March 1, 2002; 71(3): 469 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. U. Meduri, S. Kanangat, M. Bronze, D. R. Patterson, C. U. Meduri, C. Pak, E. A. Tolley, and D. R. Schaberg Effects of Methylprednisolone on Intracellular Bacterial Growth Clin. Vaccine Immunol., November 1, 2001; 8(6): 1156 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vollstedt, M. Franchini, G. Alber, M. Ackermann, and M. Suter Interleukin-12- and Gamma Interferon-Dependent Innate Immunity Are Essential and Sufficient for Long-Term Survival of Passively Immunized Mice Infected with Herpes Simplex Virus Type 1 J. Virol., October 15, 2001; 75(20): 9596 - 9600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Stumpf, C. Shimeld, D. L. Easty, and T. J. Hill Cytokine Production in a Murine Model of Recurrent Herpetic Stromal Keratitis Invest. Ophthalmol. Vis. Sci., February 1, 2001; 42(2): 372 - 378. [Abstract] [Full Text]
|
|
|
|
|
|
L. Malmgaard, S. R. Paludan, S. C. Mogensen, and S. Ellermann-Eriksen Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-{kappa}B J. Gen. Virol., December 1, 2000; 81(12): 3011 - 3020. [Abstract] [Full Text]
|
|
|
|
|
|
S. Noisakran and D. J. J. Carr Plasmid DNA Encoding IFN-{alpha}1 Antagonizes Herpes Simplex Virus Type 1 Ocular Infection Through CD4+ and CD8+ T Lymphocytes J. Immunol., June 15, 2000; 164(12): 6435 - 6443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Ali, C. S. McLean, M. E. G. Boursnell, G. Martin, C. L. Holmes, S. Reeder, C. Entwisle, D. M. Blakeley, J. G. Shields, S. Todryk, et al. Preclinical Evaluation of "Whole" Cell Vaccines for Prophylaxis and Therapy Using a Disabled Infectious Single Cycle-Herpes Simplex Virus Vector to Transduce Cytokine Genes Cancer Res., March 1, 2000; 60(6): 1663 - 1670. [Abstract] [Full Text]
|
|
|
|
|
|
S. Gangappa, S. P. Deshpande, and B. T. Rouse Bystander Activation of CD4+ T Cells Accounts for Herpetic Ocular Lesions Invest. Ophthalmol. Vis. Sci., February 1, 2000; 41(2): 453 - 459. [Abstract] [Full Text]
|
|
|
|
|
|
M. van den Broek, M. F. Bachmann, G. Kohler, M. Barner, R. Escher, R. Zinkernagel, and M. Kopf IL-4 and IL-10 Antagonize IL-12-Mediated Protection Against Acute Vaccinia Virus Infection with a Limited Role of IFN-{gamma} and Nitric Oxide Synthetase 2 J. Immunol., January 1, 2000; 164(1): 371 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gosselin, A. TomoIu, R. C. Gallo, and L. Flamand Interleukin-15 as an Activator of Natural Killer Cell-Mediated Antiviral Response Blood, December 15, 1999; 94(12): 4210 - 4219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kanangat, G. U. Meduri, E. A. Tolley, D. R. Patterson, C. U. Meduri, C. Pak, J. P. Griffin, M. S. Bronze, and D. R. Schaberg Effects of Cytokines and Endotoxin on the Intracellular Growth of Bacteria Infect. Immun., June 1, 1999; 67(6): 2834 - 2840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Gherardi, J. C. Ramirez, D. Rodriguez, J. R. Rodriguez, G.-I. Sano, F. Zavala, and M. Esteban IL-12 Delivery from Recombinant Vaccinia Virus Attenuates the Vector and Enhances the Cellular Immune Response Against HIV-1 Env in a Dose-Dependent Manner J. Immunol., June 1, 1999; 162(11): 6724 - 6733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Nguyen and C. A. Biron Synergism for Cytokine-Mediated Disease During Concurrent Endotoxin and Viral Challenges: Roles for NK and T Cell IFN-{gamma} Production J. Immunol., May 1, 1999; 162(9): 5238 - 5246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gangappa, J. S. Babu, J. Thomas, M. Daheshia, and B. T. Rouse Virus-Induced Immunoinflammatory Lesions in the Absence of Viral Antigen Recognition J. Immunol., October 15, 1998; 161(8): 4289 - 4300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Monteiro, C. Harvey, and G. Trinchieri Role of Interleukin-12 in Primary Influenza Virus Infection J. Virol., June 1, 1998; 72(6): 4825 - 4831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Toda, R. L. Martuza, H. Kojima, and S. D. Rabkin In Situ Cancer Vaccination: An IL-12 Defective Vector/Replication-Competent Herpes Simplex Virus Combination Induces Local and Systemic Antitumor Activity J. Immunol., May 1, 1998; 160(9): 4457 - 4464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Thomas and B. T. Rouse Immunopathology of Herpetic Stromal Keratitis: Discordance in CD4+ T Cell Function Between Euthymic Host and Reconstituted SCID Recipients J. Immunol., April 15, 1998; 160(8): 3965 - 3970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Mehrotra, R. P. Donnelly, S. Wong, H. Kanegane, A. Geremew, H. S. Mostowski, K. Furuke, J. P. Siegel, and E. T. Bloom Production of IL-10 by Human Natural Killer Cells Stimulated with IL-2 and/or IL-12 J. Immunol., March 15, 1998; 160(6): 2637 - 2644. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
