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The Journal of Immunology, Vol 156, Issue 12 4909-4914, Copyright © 1996 by American Association of Immunologists

ARTICLES

Characterization of murine intercellular adhesion molecule-2

H Xu, JK Bickford, E Luther, C Carpenito, F Takei and TA Springer
Department of Molecular Genetics and Protein Chemistry, Pfizer Central Research, Groton, CT 06340, USA.

Rat mAbs were raised against murine intercellular adhesion molecule-2 (ICAM-2). Immune precipitation and purification reveal that the murine ICAM-2 glycoprotein is 55 kDa and is similar in size to human ICAM-2. ICAM-2 is expressed on a variety of leukocyte cell lines, including T and B lymphoma, mastocytoma, and macrophage lines. ICAM-2 is well expressed on endothelioma cell lines, and in contrast to ICAM-1, expression is not increased by inflammatory cytokines. One of the mAb to ICAM-2 partially or completely inhibits binding of cells expressing LFA-1 to purified ICAM-2, and binding of cells expressing ICAM-2 to purified LFA-1. The findings in the mouse are congruent with those in the human, suggesting functional conservation of ICAM-2 across species.


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