The Journal of Immunology, Vol 156, Issue 12 4638-4643, Copyright © 1996 by American Association of Immunologists

ARTICLES

Enhancement of delayed-type hypersensitivity to sheep red blood cells in mice by granulocyte colony-stimulating factor administration at the elicitation phase

M Terashita, C Kudo, T Yamashita, I Gresser and F Sendo
Department of Immunology and Parasitology, Yamagata University School of Medicine, Yamagata, Japan.

We previously demonstrated that selective depletion of polymorphonuclear neutrophils by a mAb inhibits both the priming and effector phases of delayed-type hypersensitivity (DTH) to SRBC. To better understand the role of polymorphonuclear neutrophils in DTH, we examined the effect of granulocyte CSF (G-CSF) on DTH to SRBC in mice. G-CSF administered at the elicitation phase enhanced a DTH response that was weak in control G-CSF-untreated mice. This treatment also augmented mononuclear leukocyte recruitment in DTH in these mice. However, G-CSF administration failed to augment priming of DTH to SRBC under any conditions examined.

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