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The Journal of Immunology, Vol 156, Issue 11 4079-4082, Copyright © 1996 by American Association of Immunologists

CUTTING EDGE

Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice

LF Wang, JY Lin, KH Hsieh and RH Lin
Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.

Hapten-induced contact hypersensitivity has been well-characterized in humans as well as in animal models. However, it is not clear whether or not protein Ag can directly sensitize epicutaneously and induce a primary immune response. We demonstrated in this study, for the first time, that through epicutaneous exposure protein Ag in the absence of adjuvant sensitizes animals and induces a predominant Th2-like response. Furthermore, mice receiving repeated protein Ag sustained elevated levels of specific IgE. This animal model can be used to investigate the molecular mechanism controlling the differential Th1/Th2 development in skin diseases.


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