The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mieza, M. A.
Right arrow Articles by Taniguchi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mieza, M. A.
Right arrow Articles by Taniguchi, M.

The Journal of Immunology, Vol 156, Issue 10 4035-4040, Copyright © 1996 by American Association of Immunologists

ARTICLES

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice

MA Mieza, T Itoh, JQ Cui, Y Makino, T Kawano, K Tsuchida, T Koike, T Shirai, H Yagita, A Matsuzawa, H Koseki and M Taniguchi
Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, Japan.

A novel peripheral T cell subset characterized by the expression of a NK marker and invariant TCR encoded by V alpha 14 J alpha 281 gene segments with a 1-base N-region was investigated in relation to autoimmune disease development. First, we observed that invariant V alpha 14+ NK T cells are specifically reduced with aging in C57BL/6 lpr/lpr or MRL lpr/lpr mice, whereas no change was observed in age- matched control C57BL/6 or MRL +/+ mice as determined by FACS analysis and RNase protection assay. This reduction precedes the disease development and could also be detected in other autoimmune disease- prone mice, such as C3H gld/gld and (NZB x NZW)F1 mice. These results suggest that the specific decrease in invariant V alpha 14+ NK T cells correlates strongly with the development of autoimmunity. Second, injection of MRL lpr/lpr mice with anti-V alpha 14 mAb resulted in the early onset and exacerbation of lymphosplenomegaly due to the accumulation of abnormal CD3+ B220+ CD4-CD8- T cells as well as an increase in the titers of anti-dsDNA autoantibodies. These results indicate that V alpha 14+ NK T cells regulate autoimmune responses and play a crucial role in controlling the development of autoimmune diseases.


This article has been cited by other articles:


Home page
 J. Virol.Home page
I. Tsunoda, T. Tanaka, and R. S. Fujinami
Regulatory Role of CD1d in Neurotropic Virus Infection
J. Virol., October 15, 2008; 82(20): 10279 - 10289.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Williams, J. M. Lumsden, X. Yu, L. Feigenbaum, J. Zhang, S. M. Steinberg, and R. J. Hodes
Regulation of Thymic NKT Cell Development by the B7-CD28 Costimulatory Pathway
J. Immunol., July 15, 2008; 181(2): 907 - 917.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Tsukamoto, M. Ohtsuji, W. Shiroiwa, Q. Lin, K. Nakamura, H. Tsurui, Y. Jiang, K. Sudo, H. Nishimura, T. Shirai, et al.
Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis
J. Immunol., April 1, 2008; 180(7): 4530 - 4539.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Loh, Y.-C. Cai, G. Bonventi, G. Lajoie, R. MacLeod, and J. E. Wither
Dissociation of the Genetic Loci Leading to B1a and NKT Cell Expansions from Autoantibody Production and Renal Disease in B6 Mice with an Introgressed New Zealand Black Chromosome 4 Interval
J. Immunol., February 1, 2007; 178(3): 1608 - 1617.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Iwai, Y. Tomita, S. Okano, I. Shimizu, Y. Yasunami, T. Kajiwara, Y. Yoshikai, M. Taniguchi, K. Nomoto, and H. Yasui
Regulatory Roles of NKT Cells in the Induction and Maintenance of Cyclophosphamide-Induced Tolerance
J. Immunol., December 15, 2006; 177(12): 8400 - 8409.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. D. Gadola, M. Koch, J. Marles-Wright, N. M. Lissin, D. Shepherd, G. Matulis, K. Harlos, P. M. Villiger, D. I. Stuart, B. K. Jakobsen, et al.
Structure and binding kinetics of three different human CD1d-{alpha}-galactosylceramide-specific T cell receptors
J. Exp. Med., March 20, 2006; 203(3): 699 - 710.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Komori, H. Furukawa, S. Mori, M. R. Ito, M. Terada, M.-C. Zhang, N. Ishii, N. Sakuma, M. Nose, and M. Ono
A Signal Adaptor SLAM-Associated Protein Regulates Spontaneous Autoimmunity and Fas-Dependent Lymphoproliferation in MRL-Faslpr Lupus Mice
J. Immunol., January 1, 2006; 176(1): 395 - 400.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. Osada, M. A. Morse, H. K. Lyerly, and T. M. Clay
Ex vivo expanded human CD4+ regulatory NKT cells suppress expansion of tumor antigen-specific CTLs
Int. Immunol., September 1, 2005; 17(9): 1143 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Forestier, A. Molano, J. S. Im, Y. Dutronc, B. Diamond, A. Davidson, P. A. Illarionov, G. S. Besra, and S. A. Porcelli
Expansion and Hyperactivity of CD1d-Restricted NKT Cells during the Progression of Systemic Lupus Erythematosus in (New Zealand Black x New Zealand White)F1 Mice
J. Immunol., July 15, 2005; 175(2): 763 - 770.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H.-H. Lin, D. E. Faunce, M. Stacey, A. Terajewicz, T. Nakamura, J. Zhang-Hoover, M. Kerley, M. L. Mucenski, S. Gordon, and J. Stein-Streilein
The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
J. Exp. Med., May 16, 2005; 201(10): 1615 - 1625.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Oh, S. Kim, S.-H. Park, H. Gu, D. Roopenian, D. H. Chung, Y. S. Kim, and D.-S. Lee
Direct Regulatory Role of NKT Cells in Allogeneic Graft Survival Is Dependent on the Quantitative Strength of Antigenicity
J. Immunol., February 15, 2005; 174(4): 2030 - 2036.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Tao, L. Shangwu, W. Qun, L. Yan, J. Wei, L. Junyan, G. Feili, J. Boquan, and T. Jinquan
CD226 Expression Deficiency Causes High Sensitivity to Apoptosis in NK T Cells from Patients with Systemic Lupus Erythematosus
J. Immunol., February 1, 2005; 174(3): 1281 - 1290.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Matsumoto, E. Kubota, Y. Omi, U. Lee, and J. M. Penninger
Essential Role of LFA-1 in Activating Th2-Like Responses by {alpha}-Galactosylceramide-Activated NKT Cells
J. Immunol., October 15, 2004; 173(8): 4976 - 4984.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Falcone, F. Facciotti, N. Ghidoli, P. Monti, S. Olivieri, L. Zaccagnino, E. Bonifacio, G. Casorati, F. Sanvito, and N. Sarvetnick
Up-Regulation of CD1d Expression Restores the Immunoregulatory Function of NKT Cells and Prevents Autoimmune Diabetes in Nonobese Diabetic Mice
J. Immunol., May 15, 2004; 172(10): 5908 - 5916.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Teige, I. Teige, S. Lavasani, R. Bockermann, E. Mondoc, R. Holmdahl, and S. Issazadeh-Navikas
CD1-Dependent Regulation of Chronic Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis
J. Immunol., January 1, 2004; 172(1): 186 - 194.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-Q. Yang, V. Saxena, H. Xu, L. Van Kaer, C.-R. Wang, and R. R. Singh
Repeated {alpha}-Galactosylceramide Administration Results in Expansion of NK T Cells and Alleviates Inflammatory Dermatitis in MRL-lpr/lpr Mice
J. Immunol., October 15, 2003; 171(8): 4439 - 4446.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. M. Esteban, T. Tsoutsman, M. A. Jordan, D. Roach, L. D. Poulton, A. Brooks, O. V. Naidenko, S. Sidobre, D. I. Godfrey, and A. G. Baxter
Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci
J. Immunol., September 15, 2003; 171(6): 2873 - 2878.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-Q. Yang, A. K. Singh, M. T. Wilson, M. Satoh, A. K. Stanic, J.-J. Park, S. Hong, S. D. Gadola, A. Mizutani, S. R. Kakumanu, et al.
Immunoregulatory Role of CD1d in the Hydrocarbon Oil-Induced Model of Lupus Nephritis
J. Immunol., August 15, 2003; 171(4): 2142 - 2153.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Matsuki, A. K. Stanic, M. E. Embers, L. Van Kaer, L. Morel, and S. Joyce
Genetic Dissection of V{alpha}14J{alpha}18 Natural T Cell Number and Function in Autoimmune-Prone Mice
J. Immunol., June 1, 2003; 170(11): 5429 - 5437.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
L E Schiffer, N Hussain, X Wang, W Huang, J Sinha, M Ramanujam, and A Davidson
Lowering anti-dsDNA antibodies--what's new?
Lupus, December 1, 2002; 11(12): 885 - 894.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
T. Inui, R. Nakagawa, S. Ohkura, Y. Habu, Y. Koike, K. Motoki, N. Kuranaga, M. Fukasawa, N. Shinomiya, and S. Seki
Age-Associated Augmentation of the Synthetic Ligand- Mediated Function of Mouse NK1.1 Ag+ T Cells: Their Cytokine Production and Hepatotoxicity In Vivo and In Vitro
J. Immunol., December 1, 2002; 169(11): 6127 - 6132.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Y. Oikawa, A. Shimada, S. Yamada, Y. Motohashi, Y. Nakagawa, J.-i. Irie, T. Maruyama, and T. Saruta
High Frequency of V{alpha}24+ V{beta}11+ T-Cells Observed in Type 1 Diabetes
Diabetes Care, October 1, 2002; 25(10): 1818 - 1823.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. E. Faunce and J. Stein-Streilein
NKT Cell-Derived RANTES Recruits APCs and CD8+ T Cells to the Spleen During the Generation of Regulatory T Cells in Tolerance
J. Immunol., July 1, 2002; 169(1): 31 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. T. Mars, V. Laloux, K. Goude, S. Desbois, A. Saoudi, L. Van Kaer, H. Lassmann, A. Herbelin, A. Lehuen, and R. S. Liblau
Cutting Edge: V{alpha}14-J{alpha}281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice
J. Immunol., June 15, 2002; 168(12): 6007 - 6011.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. D. Gadola, N. Dulphy, M. Salio, and V. Cerundolo
V{alpha}24-J{alpha}Q-Independent, CD1d-Restricted Recognition of {alpha}-Galactosylceramide by Human CD4+ and CD8{alpha}{beta}+ T Lymphocytes
J. Immunol., June 1, 2002; 168(11): 5514 - 5520.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Duthie and S. J. Kahn
Treatment with {alpha}-Galactosylceramide Before Trypanosoma cruzi Infection Provides Protection or Induces Failure to Thrive
J. Immunol., June 1, 2002; 168(11): 5778 - 5785.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
G. Gonzalez-Aseguinolaza, L. Van Kaer, C. C. Bergmann, J. M. Wilson, J. Schmieg, M. Kronenberg, T. Nakayama, M. Taniguchi, Y. Koezuka, and M. Tsuji
Natural Killer T Cell Ligand {alpha}-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines
J. Exp. Med., March 4, 2002; 195(5): 617 - 624.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. E. Gumperz, S. Miyake, T. Yamamura, and M. B. Brenner
Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining
J. Exp. Med., March 4, 2002; 195(5): 625 - 636.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. W. Jahng, I. Maricic, B. Pedersen, N. Burdin, O. Naidenko, M. Kronenberg, Y. Koezuka, and V. Kumar
Activation of Natural Killer T Cells Potentiates or Prevents Experimental Autoimmune Encephalomyelitis
J. Exp. Med., December 17, 2001; 194(12): 1789 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. K. Singh, M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer
Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis
J. Exp. Med., December 17, 2001; 194(12): 1801 - 1811.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kawakami, Y. Kinjo, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Nakayama, M. Taniguchi, and A. Saito
Monocyte Chemoattractant Protein-1-Dependent Increase of V{alpha}14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection
J. Immunol., December 1, 2001; 167(11): 6525 - 6532.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. N. Naumov, K. S. Bahjat, R. Gausling, R. Abraham, M. A. Exley, Y. Koezuka, S. B. Balk, J. L. Strominger, M. Clare-Salzer, and S. B. Wilson
Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets
PNAS, November 9, 2001; (2001) 251531798.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
S.M. Rhind
CD1--The Pathology Perspective
Vet. Pathol., November 1, 2001; 38(6): 611 - 619.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Muhammad Ali Tahir, O. Cheng, A. Shaulov, Y. Koezuka, G. J. Bubley, S. B. Wilson, S. P. Balk, and M. A. Exley
Loss of IFN-{gamma} Production by Invariant NK T Cells in Advanced Cancer
J. Immunol., October 1, 2001; 167(7): 4046 - 4050.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
D Baeten, N Van Damme, F Van den Bosch, E Kruithof, M De Vos, H Mielants, E M Veys, and F De Keyser
Impaired Th1 cytokine production in spondyloarthropathy is restored by anti-TNF{alpha}
Ann Rheum Dis, August 1, 2001; 60(8): 750 - 755.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. D. Poulton, M. J. Smyth, C. G. Hawke, P. Silveira, D. Shepherd, O. V. Naidenko, D. I. Godfrey, and A. G. Baxter
Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice
Int. Immunol., July 1, 2001; 13(7): 887 - 896.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F.-D. Shi, M. Flodstrom, B. Balasa, S. H. Kim, K. Van Gunst, J. L. Strominger, S. B. Wilson, and N. Sarvetnick
Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse
PNAS, June 5, 2001; 98(12): 6777 - 6782.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
N. Kadowaki, S. Antonenko, S. Ho, M.-C. Rissoan, V. Soumelis, S. A. Porcelli, L. L. Lanier, and Y.-J. Liu
Distinct Cytokine Profiles of Neonatal Natural Killer T Cells after Expansion with Subsets of Dendritic Cells
J. Exp. Med., May 21, 2001; 193(10): 1221 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
Y. Wang, I. Goldschneider, J. O’Rourke, and R. E. Cone
Blood mononuclear cells induce regulatory NK T thymocytes in anterior chamber-associated immune deviation
J. Leukoc. Biol., May 1, 2001; 69(5): 741 - 746.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
K. Yamazaki, Y. Ohsawa, and H. Yoshie
Elevated Proportion of Natural Killer T Cells in Periodontitis Lesions : A Common Feature of Chronic Inflammatory Diseases
Am. J. Pathol., April 1, 2001; 158(4): 1391 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. B. Fritz and M.-L. Zhao
Regulation of Experimental Autoimmune Encephalomyelitis in the C57BL/6J Mouse by NK1.1+, DX5+, {{alpha}}{{beta}}+ T Cells
J. Immunol., March 15, 2001; 166(6): 4209 - 4215.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K.-i. Seino, K. Fukao, K. Muramoto, K. Yanagisawa, Y. Takada, S. Kakuta, Y. Iwakura, L. Van Kaer, K. Takeda, T. Nakayama, et al.
Requirement for natural killer T (NKT) cells in the induction of allograft tolerance
PNAS, February 15, 2001; (2001) 41608298.
[Abstract] [Full Text]

Home page
 Infect. Immun.Home page
K. Kawakami, Y. Kinjo, S. Yara, Y. Koguchi, K. Uezu, T. Nakayama, M. Taniguchi, and A. Saito
Activation of V{alpha}14+ Natural Killer T Cells by {alpha}-Galactosylceramide Results in Development of Th1 Response and Local Host Resistance in Mice Infected with Cryptococcus neoformans
Infect. Immun., January 1, 2001; 69(1): 213 - 220.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K.-H. Sonoda, D. E. Faunce, M. Taniguchi, M. Exley, S. Balk, and J. Stein-Streilein
NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance
J. Immunol., January 1, 2001; 166(1): 42 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Pal, T. Tabira, T. Kawano, M. Taniguchi, S. Miyake, and T. Yamamura
Costimulation-Dependent Modulation of Experimental Autoimmune Encephalomyelitis by Ligand Stimulation of V{{alpha}}14 NK T Cells
J. Immunol., January 1, 2001; 166(1): 662 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. M. Araujo, A. Puel, C. Gouarin, A. Hameg, J.-C. Mevel, Y. Koezuka, J.-F. Bach, D. Mouton, and A. Herbelin
NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: gene mapping in the interval-specific congenic strains raised for immunomodulatory genes
Int. Immunol., November 1, 2000; 12(11): 1613 - 1622.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Hameg, I. Apostolou, M. Leite-de-Moraes, J.-M. Gombert, C. Garcia, Y. Koezuka, J.-F. Bach, and A. Herbelin
A Subset of NKT Cells That Lacks the NK1.1 Marker, Expresses CD1d Molecules, and Autopresents the {alpha}-Galactosylceramide Antigen
J. Immunol., November 1, 2000; 165(9): 4917 - 4926.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. C. Leite-de-Moraes, A. Herbelin, C. Gouarin, Y. Koezuka, E. Schneider, and M. Dy
Fas/Fas Ligand Interactions Promote Activation-Induced Cell Death of NK T Lymphocytes
J. Immunol., October 15, 2000; 165(8): 4367 - 4371.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. O. Yang, F. K. Racke, P. T. Nguyen, R. Gausling, M. E. Severino, H. F. Horton, M. C. Byrne, J. L. Strominger, and S. B. Wilson
CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of V{alpha}24J{alpha}Q T Cells: A Feedback Mechanism for Immune Regulation
J. Immunol., October 1, 2000; 165(7): 3756 - 3762.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Bonish, D. Jullien, Y. Dutronc, B. B. Huang, R. Modlin, F. M. Spada, S. A. Porcelli, and B. J. Nickoloff
Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-{gamma} Production by NK-T Cells
J. Immunol., October 1, 2000; 165(7): 4076 - 4085.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Apostolou, A. Cumano, G. Gachelin, and P. Kourilsky
Evidence for Two Subgroups of CD4-CD8- NKT Cells with Distinct TCR{alpha}{beta} Repertoires and Differential Distribution in Lymphoid Tissues
J. Immunol., September 1, 2000; 165(5): 2481 - 2490.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Gonzalez-Aseguinolaza, C. de Oliveira, M. Tomaska, S. Hong, O. Bruna-Romero, T. Nakayama, M. Taniguchi, A. Bendelac, L. Van Kaer, Y. Koezuka, et al.
alpha -Galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria
PNAS, July 18, 2000; 97(15): 8461 - 8466.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Elewaut, L. Brossay, S. M. Santee, O. V. Naidenko, N. Burdin, H. De Winter, J. Matsuda, C. F. Ware, H. Cheroutre, and M. Kronenberg
Membrane Lymphotoxin Is Required for the Development of Different Subpopulations of NK T Cells
J. Immunol., July 15, 2000; 165(2): 671 - 679.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Skold, N. N. Faizunnessa, C.-R. Wang, and S. Cardell
CD1d-Specific NK1.1+ T Cells with a Transgenic Variant TCR
J. Immunol., July 1, 2000; 165(1): 168 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Joyce
Natural T cells: Cranking up the immune system by prompt cytokine secretion
PNAS, June 20, 2000; 97(13): 6933 - 6935.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Zeng, M.-K. Lee, J. Tung, A. Brendolan, and S. Strober
Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice
J. Immunol., May 15, 2000; 164(10): 5000 - 5004.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Olivares-Villagomez, A. K. Wensky, Y. Wang, and J. J. Lafaille
Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis
J. Immunol., May 15, 2000; 164(10): 5499 - 5507.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Illes, T. Kondo, J. Newcombe, N. Oka, T. Tabira, and T. Yamamura
Differential Expression of NK T Cell V{alpha}24J{alpha}Q Invariant TCR Chain in the Lesions of Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy
J. Immunol., April 15, 2000; 164(8): 4375 - 4381.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. J. J. van der Vliet, N. Nishi, T. D. de Gruijl, B. M. E. von Blomberg, A. J. M. van den Eertwegh, H. M. Pinedo, G. Giaccone, and R. J. Scheper
Human natural killer T cells acquire a memory-activated phenotype before birth
Blood, April 1, 2000; 95(7): 2440 - 2442.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. L. Walunas, B. Wang, C.-R. Wang, and J. M. Leiden
Cutting Edge: The Ets1 Transcription Factor Is Required for the Development of NK T Cells in Mice
J. Immunol., March 15, 2000; 164(6): 2857 - 2860.
[Abstract] [Full Text] [PDF]

Home page