The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shanmugam, A.
Right arrow Articles by Tournier-Lasserve, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shanmugam, A.
Right arrow Articles by Tournier-Lasserve, E.

The Journal of Immunology, Vol 156, Issue 10 3747-3754, Copyright © 1996 by American Association of Immunologists

ARTICLES

TCR alpha beta gene usage for myelin basic protein recognition in healthy monozygous twins

A Shanmugam, C Copie-Bergman, B Falissard, O Delrieu, JP Jais, D Rebibo, JF Bach and E Tournier-Lasserve
INSERM Unit 25, Necker Faculty of Medicine, Paris, France.

The pathogenic role of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) has been suggested by the encephalitogenicity of MBP-specific T cells in experimental allergic encephalomyelitis (EAE). In humans, extensive analysis of TCRs involved in MBP recognition has led to conflicting results, varying from an intra- and/or interindividual restriction to high diversity in TCRAV/TCRBV gene usage. We previously established MBP-specific T cell lines (TCLs) from healthy monozygous twins and characterized their fine epitope specificity. In this study, we report on the TCR alpha beta gene usage of 52 of these MBP TCLs that are specific for epitopes recognized by both co-twins within the same pair. High overall diversity in the TCR alpha and TCR beta genes used for recognition of this self-Ag, MBP, was observed. Variable genes belonging to 19 different TCRAV and 16 different TCRBV subfamilies are expressed by the 52 TCLs herein studied. In co-twins, TCLs utilized genes belonging to common TCRAV and/or TCRBV gene subfamilies in 7 of 13 instances of shared epitope recognition. Statistical analysis of intrapair concordance for TCR gene usage for the recognition of a given peptide did not show any significant deviation from values that would be anticipated in the absence of genetic background effect.


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
P. Somma, G. Ristori, L. Battistini, S. Cannoni, G. Borsellino, A. Diamantini, M. Salvetti, R. Sorrentino, and M. T. Fiorillo
Characterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis
J. Leukoc. Biol., March 1, 2007; 81(3): 696 - 710.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Brisebois, S. P. Zehntner, J. Estrada, T. Owens, and S. Fournier
A Pathogenic Role for CD8+ T Cells in a Spontaneous Model of Demyelinating Disease
J. Immunol., August 15, 2006; 177(4): 2403 - 2411.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. R Oksenberg, G. T Stavri, M. C Jeong, Natara Garovoy, J. R Salisbury, and J. D Erusalimsky
Analysis of the T-cell receptor repertoire in human atherosclerosis
Cardiovasc Res, November 1, 1997; 36(2): 256 - 267.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.