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The Journal of Immunology, Vol 156, Issue 10 3638-3644, Copyright © 1996 by American Association of Immunologists
ARTICLES |
A Glass, CM Walsh, DH Lynch and WR Clark
Department of Biology, University of California, Los Angeles 90095, USA.
Cloned murine CTL activated via the TCR or by PMA and ionomycin up- regulate surface Fas ligand and show an increased ability to kill non- Ag-specific Fas+ target cells. This up-regulation starts after 45 to 60 min and has a t1/2 for reversal of about 90 min. Up-regulation of lytic function is accompanied by up-regulation of Fas ligand on the CTL surface, which can be blocked by protein synthesis inhibitors. When up- regulation of Fas lytic function was induced by PMA and ionomycin, EGTA blocked both activation of lytic function and expression of Fas ligand detected by FACS analysis. However, when up-regulation was induced by specific Ag, EGTA blocked activation of lytic function, but not up- regulation of Fas ligand. Moreover, EL-4 cells have very high levels of surface Fas ligand, although they are not cytotoxic. Thus, expression of surface Fas ligand may be required, but not sufficient, for Fas- mediated lysis.
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