The Journal of Immunology, Vol 156, Issue 1 93-99, Copyright © 1996 by American Association of Immunologists

ARTICLES

Catecholamines modulate human NK cell circulation and function via spleen-independent beta 2-adrenergic mechanisms

M Schedlowski, W Hosch, R Oberbeck, RJ Benschop, R Jacobs, HR Raab and RE Schmidt
Department of Medicine and Dermatology, Hannover Medical School, Germany.

Increases in catecholamines have been shown to induce changes in migration of lymphocytes, in particular NK cells. To analyze the mechanisms of catecholamine-induced NK cell trafficking, normal healthy male human subjects and splenectomized individuals were infused with either adrenaline (0.10 microgram/kg/min), noradrenaline (0.15 microgram/kg/min), or NaCl i.v. for 20 min. Lymphocyte subsets (CD3+, CD4+, CD8+) transiently increased after administration of both catecholamines, with most pronounced increases (up to 600%) in NK cell numbers (CD16+ or CD56+) after infusion of adrenaline. These changes in NK cell numbers and function were accompanied neither by alterations in expression of adhesion molecules (CD11a), CD11b, CD31, CD43, CD44, CD62L) on NK cells nor by changes in plasma concentrations of soluble (s) adhesion molecules (sVCAM-1, sICAM-1, sE-selectin). Comparable increases in lymphocyte subsets were observed in splenectomized subjects, suggesting lymphocyte recruitment from other sources than the spleen. Furthermore, catecholamine-induced increases in lymphocyte subsets could be inhibited by pretreatment with the nonselective beta- adrenoceptor antagonist propranolol, but not by the beta1-selective antagonist bisoprolol. These data demonstrate that adrenaline and noradrenaline modulate the migratory capacity of human NK cells via spleen-independent beta 2-adrenoceptor mechanism.

This article has been cited by other articles:

				S. Kern and T. Ziemssen Review: Brain immune communication psychoneuroimmunology of multiple sclerosis Multiple Sclerosis, January 1, 2008; 14(1): 6 - 21. [Abstract] [PDF]

				A. E. Pontiroli, P. Pizzocri, R. Paroni, and F. Folli Sympathetic Overactivity, Endothelial Dysfunction, Inflammation, and Metabolic Abnormalities Cluster in Grade III (World Health Organization) Obesity: Reversal through sustained weight loss obtained with laparoscopic adjustable gastric banding Diabetes Care, December 1, 2006; 29(12): 2735 - 2738. [Full Text] [PDF]

				R H Straub, R Wiest, U G Strauch, P Harle, and J Scholmerich The role of the sympathetic nervous system in intestinal inflammation. Gut, November 1, 2006; 55(11): 1640 - 1649. [Full Text] [PDF]

				C Rajda, K Bencsik, J Fuvesi, E Seres, L Vecsei, and J Bergquist The norepinephrine level is decreased in the lymphocytes of long-term interferon-beta-treated multiple sclerosis patients Multiple Sclerosis, June 1, 2006; 12(3): 265 - 270. [Abstract] [PDF]

				P Harle, R H Straub, R Wiest, A Mayer, J Scholmerich, F Atzeni, M Carrabba, M Cutolo, and P Sarzi-Puttini Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems Ann Rheum Dis, January 1, 2006; 65(1): 51 - 56. [Abstract] [Full Text] [PDF]

				K. Takeda and K. Okumura CAM and NK Cells Evid. Based Complement. Altern. Med., June 1, 2004; 1(1): 17 - 27. [Abstract] [Full Text] [PDF]

				G. E. Demas, T. J. Bartness, R. J. Nelson, and D. L. Drazen Photoperiod modulates the effects of norepinephrine on lymphocyte proliferation in Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R873 - R879. [Abstract] [Full Text] [PDF]

				F. A. Jain, L.-h. Zhao, M. K. Selig, and R. L. Kradin, Epinephrine promotes pulmonary angiitis: evidence for a {beta}1-adrenoreceptor-mediated mechanism Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L232 - L239. [Abstract] [Full Text] [PDF]

				M. U. GOEBEL, A. E. TREBST, J. STEINER, Y. F. XIE, M. S. EXTON, S. FREDE, A. E. CANBAY, M. C. MICHEL, U. HEEMANN, and M. SCHEDLOWSKI Behavioral conditioning of immunosuppression is possible in humans FASEB J, December 1, 2002; 16(14): 1869 - 1873. [Abstract] [Full Text] [PDF]

				J. M. Kittner, R. Jacobs, C. R. Pawlak, C. J. Heijnen, M. Schedlowski, and R. E. Schmidt Adrenaline-induced immunological changes are altered in patients with rheumatoid arthritis Rheumatology, September 1, 2002; 41(9): 1031 - 1039. [Abstract] [Full Text] [PDF]

				S. A. Motzer, M. Jarrett, M. M. Heitkemper, and J. Tsuji Natural Killer Cell Function and Psychological Distress in Women with and without Irritable Bowel Syndrome Biol Res Nurs, July 1, 2002; 4(1): 31 - 42. [Abstract] [PDF]

				R. Jacobs, C. R. Pawlak, E. Mikeska, D. Meyer-Olson, M. Martin, C. J. Heijnen, M. Schedlowski, and R. E. Schmidt Systemic lupus erythematosus and rheumatoid arthritis patients differ from healthy controls in their cytokine pattern after stress exposure Rheumatology, August 1, 2001; 40(8): 868 - 875. [Abstract] [Full Text] [PDF]

				I. J. Elenkov, R. L. Wilder, G. P. Chrousos, and E. S. Vizi The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System Pharmacol. Rev., December 1, 2000; 52(4): 595 - 638. [Abstract] [Full Text] [PDF]

				F. Nagao, M. Suzui, K. Takeda, H. Yagita, and K. Okumura Mobilization of NK cells by exercise: downmodulation of adhesion molecules on NK cells by catecholamines Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1251 - R1256. [Abstract] [Full Text] [PDF]

				B. Steppich, F. Dayyani, R. Gruber, R. Lorenz, M. Mack, and H. W. L. Ziegler-Heitbrock Selective mobilization of CD14+CD16+ monocytes by exercise Am J Physiol Cell Physiol, September 1, 2000; 279(3): C578 - C586. [Abstract] [Full Text] [PDF]

				K. Schaller, D. Mechau, H. G. Scharmann, M. Weiss, M. Baum, and H. Liesen Increased training load and the beta -adrenergic-receptor system on human lymphocytes J Appl Physiol, July 1, 1999; 87(1): 317 - 324. [Abstract] [Full Text] [PDF]

				M. S. Exton, M. Schult, S. Donath, T. Strubel, U. Bode, A. del Rey, J. Westermann, and M. Schedlowski Conditioned immunosuppression makes subtherapeutic cyclosporin effective via splenic innervation Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1710 - R1717. [Abstract] [Full Text] [PDF]

				M. S. Exton, A. Bindert, T. Kruger, F. Scheller, U. Hartmann, and M. Schedlowski Cardiovascular and Endocrine Alterations After Masturbation-Induced Orgasm in Women Psychosom Med, May 1, 1999; 61(3): 280 - 289. [Abstract] [Full Text] [PDF]

				M. P. Miles, S. K. Leach, W. J. Kraemer, K. Dohi, J. A. Bush, and A. M. Mastro Leukocyte adhesion molecule expression during intense resistance exercise J Appl Physiol, May 1, 1998; 84(5): 1604 - 1609. [Abstract] [Full Text] [PDF]

				G. Shakhar and S. Ben-Eliyahu In Vivo {beta}-Adrenergic Stimulation Suppresses Natural Killer Activity and Compromises Resistance to Tumor Metastasis in Rats J. Immunol., April 1, 1998; 160(7): 3251 - 3258. [Abstract] [Full Text] [PDF]