| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 156, Issue 1 310-315, Copyright © 1996 by American Association of Immunologists
ARTICLES |
S Laberge, WW Cruikshank, DJ Beer and DM Center
Pulmonary Center, Boston University School of Medicine, MA 02118, USA.
At sites of inflammation, mononuclear cells are in close contact with aggregated platelets. Although the physiologic role of this association is not clear, this proximity suggests that platelet-derived mediators may play a role in chemoattraction of T lymphocytes. In the current study we investigated serotonin receptor-bearing lymphocyte modulation of T cell migration. Serotonin-stimulated human blood mononuclear cells secrete lymphocyte chemoattractant activity with selective activity for CD4+ T cells. This chemoattractant activity was observed within 2 h of exposure to serotonin and was blocked by serotonin type 2 receptor antagonists. Molecular sieve chromatography of supernatant from serotonin-stimulated PBMCs revealed a single peak of T cell chemoattractant activity with an apparent molecular mass of 56 kDa and a pl of 9.1. Neutralizing experiments with specific mAbs indicated that the serotonin-induced chemotactic factor was the previously characterized lymphocyte chemoattractant factor (LCF), recently designated IL-16. Serotonin induced secretion of IL-16 from CD8+, not CD4+, T cells which did not require the de novo protein synthesis. These studies suggest that serotonin, via serotonin type 2 receptors, may promote the recruitment of CD4+ T lymphocytes into an inflammatory focus.
This article has been cited by other articles:
|
|
 |
|
  M. Leon-Ponte,, G. P. Ahern, and P. J. O'Connell Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor Blood, April 15, 2007; 109(8): 3139 - 3146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Durk, E. Panther, T. Muller, S. Sorichter, D. Ferrari, C. Pizzirani, F. Di Virgilio, D. Myrtek, J. Norgauer, and M. Idzko 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes Int. Immunol., May 1, 2005; 17(5): 599 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X-J. Qin, H-Z. Shi, Z-X. Huang, L-F. Kang, W-N. Mo, and C. Wu Interleukin-16 in tuberculous and malignant pleural effusions Eur. Respir. J., April 1, 2005; 25(4): 605 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Idzko, E. Panther, C. Stratz, T. Muller, H. Bayer, G. Zissel, T. Durk, S. Sorichter, F. Di Virgilio, M. Geissler, et al. The Serotoninergic Receptors of Human Dendritic Cells: Identification and Coupling to Cytokine Release J. Immunol., May 15, 2004; 172(10): 6011 - 6019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gawaz Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium Cardiovasc Res, February 15, 2004; 61(3): 498 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. F. Little, E. Lynch, G. Fine, D. M. Center, and W. W. Cruikshank Tumor Necrosis Factor-{alpha}-Induced Synthesis of Interleukin-16 in Airway Epithelial Cells: Priming for Serotonin Stimulation Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 354 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Cloez-Tayarani, A.-F. Petit-Bertron, H. D. Venters, and J.-M. Cavaillon Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors Int. Immunol., February 1, 2003; 15(2): 233 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Cristillo and B. E. Bierer Identification of Novel Targets of Immunosuppressive Agents by cDNA-based Microarray Analysis J. Biol. Chem., February 1, 2002; 277(6): 4465 - 4476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Reich, A. Heine, S. Hugo, V. Blaschke, P. Middel, A. Kaser, H. Tilg, S. Blaschke, C. Gutgesell, and C. Neumann Engagement of the Fc{epsilon}RI Stimulates the Production of IL-16 in Langerhans Cell-Like Dendritic Cells J. Immunol., December 1, 2001; 167(11): 6321 - 6329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Seegert, P Rosenstiel, H Pfahler, P Pfefferkorn, S Nikolaus, and S Schreiber Increased expression of IL-16 in inflammatory bowel disease Gut, March 1, 2001; 48(3): 326 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshimoto, C.-R. Wang, T. Yoneto, A. Matsuzawa, W. W. Cruikshank, and H. Nariuchi Role of IL-16 in delayed-type hypersensitivity reaction Blood, May 1, 2000; 95(9): 2869 - 2874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sciaky, W. Brazer, D. M. Center, W. W. Cruikshank, and T. J. Smith Cultured Human Fibroblasts Express Constitutive IL-16 mRNA: Cytokine Induction of Active IL-16 Protein Synthesis Through a Caspase-3-Dependent Mechanism J. Immunol., April 1, 2000; 164(7): 3806 - 3814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K F Chung and P J Barnes Cytokines in asthma Thorax, September 1, 1999; 54(9): 825 - 857. [Full Text]
|
|
|
|
|
|
P. Zhou, K. Devadas, D. Tewari, A. Jegorow, and A. L. Notkins Processing, Secretion, and Anti-HIV-1 Activity of IL-16 With or Without a Signal Peptide in CD4+ T Cells J. Immunol., July 15, 1999; 163(2): 906 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Klimiuk, J. J. Goronzy, and C. M. Weyand IL-16 as an Anti-Inflammatory Cytokine in Rheumatoid Synovitis J. Immunol., April 1, 1999; 162(7): 4293 - 4299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Bannert, A. Avots, M. Baier, E. Serfling, and R. Kurth GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes PNAS, February 16, 1999; 96(4): 1541 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. H. Wu, Y. Zhang, N. A. Parada, H. Kornfeld, J. Nicoll, D. M. Center, and W. W. Cruikshank Processing and Release of IL-16 from CD4+ But Not CD8+ T Cells Is Activation Dependent J. Immunol., February 1, 1999; 162(3): 1287 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes, K. F. Chung, and C. P. Page Inflammatory Mediators of Asthma: An Update Pharmacol. Rev., December 1, 1998; 50(4): 515 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Chupp, E. A. Wright, D. Wu, M. Vallen-Mashikian, W. W. Cruikshank, D. M. Center, H. Kornfeld, and J. S. Berman Tissue and T Cell Distribution of Precursor and Mature IL-16 J. Immunol., September 15, 1998; 161(6): 3114 - 3119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Szabo, K. Zhao, I. Kirman, J. Le Maoult, R. Dyall, W. Cruikshank, and M. E. Weksler Maturation of B Cell Precursors Is Impaired in Thymic-Deprived Nude and Old Mice J. Immunol., September 1, 1998; 161(5): 2248 - 2253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Laberge, P. Ernst, O. Ghaffar, W. W. Cruikshank, H. Kornfeld, D. M. Center, and Q. Hamid Increased Expression of Interleukin-16 in Bronchial Mucosa of Subjects with Atopic Asthma Am. J. Respir. Cell Mol. Biol., August 1, 1997; 17(2): 193 - 202. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
