| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 156, Issue 1 269-274, Copyright © 1996 by American Association of Immunologists
ARTICLES |
A Ahluwalia and M Perretti
Department of Biochemical Pharmacology, Medical College of St. Bartholomew's Hospital, London, United Kingdom.
Local application of the bradykinin B1 receptor antagonist desArg9[Leu8]BK, but not the B2 receptor antagonist Hoe 140, attenuated by approximately 50% the polymorphonuclear leukocyte accumulation into 6-day-old air pouches observed in response to application of murine IL- 1 beta (5 ng). The selective appearance of a chemotactic response to the bradykinin B1 receptor agonist desArg9BK only in air pouches pretreated (4 h) with IL-1 beta indicated the involvement of this receptor type during this acute inflammation model. The pro-migratory action of desArg9BK was magnified when the effect of IL-1 on polymorphonuclear leukocyte accumulation had subsided (i.e., 24 h post- IL-1). desArg9[Leu8]BK, but not Hoe 140, antagonized the effect of desArg9BK, indicating an action on B1 receptors, but not B2 receptors. The cellular infiltration observed following application of desArg9BK in IL-1-sensitized air pouches was due to the release of neuropeptides from C fibers, as indicated by the inhibitory action of the substance P antagonist, RP 67,580, and the calcitonin-gene related peptide antagonist, CGRP-(8-37). In conclusion, this study provides evidence that activation of C fibers, which is necessary for the achievement of a full chemotactic action of IL-1, is due to up-regulation (or induction) of bradykinin B1 receptors and describes, for the first time, a relationship between these receptors and polymorphonuclear leukocyte recruitment.
This article has been cited by other articles:
|
|
 |
|
  J. Duchene, F. Lecomte, S. Ahmed, C. Cayla, J. Pesquero, M. Bader, M. Perretti, and A. Ahluwalia A Novel Inflammatory Pathway Involved in Leukocyte Recruitment: Role for the Kinin B1 Receptor and the Chemokine CXCL5 J. Immunol., October 1, 2007; 179(7): 4849 - 4856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Arndt, S. K. Young, K. R. Poch, J. A. Nick, S. Falk, R. W. Schrier, and G. S. Worthen Systemic Inhibition of the Angiotensin-Converting Enzyme Limits Lipopolysaccharide-Induced Lung Neutrophil Recruitment through Both Bradykinin and Angiotensin II-Regulated Pathways J. Immunol., November 15, 2006; 177(10): 7233 - 7241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ehrenfeld, C. Millan, C. E. Matus, J. E. Figueroa, R. A. Burgos, F. Nualart, K. D. Bhoola, and C. D. Figueroa Activation of kinin B1 receptors induces chemotaxis of human neutrophils J. Leukoc. Biol., July 1, 2006; 80(1): 117 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Souza, E. S. L. Lomez, V. Pinho, J. B. Pesquero, M. Bader, J. L. Pesquero, and M. M. Teixeira Role of Bradykinin B2 and B1 Receptors in the Local, Remote, and Systemic Inflammatory Responses That Follow Intestinal Ischemia and Reperfusion Injury J. Immunol., February 15, 2004; 172(4): 2542 - 2548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Böckmann and I. Paegelow Kinins and kinin receptors: importance for the activation of leukocytes J. Leukoc. Biol., November 1, 2000; 68(5): 587 - 592. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. G. McLean, M. Perretti, and A. Ahluwalia Kinin B1 receptors and the cardiovascular system: regulation of expression and function Cardiovasc Res, November 1, 2000; 48(2): 194 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. McLean, A. Ahluwalia, and M. Perretti Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules J. Exp. Med., July 31, 2000; 192(3): 367 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Cao, E. Pinter, S. Al-Rashed, N. Gerard, J. R. Hoult, and S. D. Brain Neurokinin-1 Receptor Agonists Are Involved in Mediating Neutrophil Accumulation in the Inflamed, But Not Normal, Cutaneous Microvasculature: An In Vivo Study Using Neurokinin-1 Receptor Knockout Mice J. Immunol., May 15, 2000; 164(10): 5424 - 5429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Prat, L. Weinrib, B. Becher, J. Poirier, P. Duquette, R. Couture, and J. P. Antel Bradykinin B1 receptor expression and function on T lymphocytes in active multiple sclerosis Neurology, December 1, 1999; 53(9): 2087 - 2087. [Abstract] [Full Text]
|
|
|
|
 |
|
 T.-J. HUANG, E.-B. HADDAD, A. J. FOX, M. SALMON, C. JONES, G. BURGESS, and K. F. CHUNG Contribution of Bradykinin B1 and B2 Receptors in Allergen-induced Bronchial Hyperresponsiveness Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1717 - 1723. [Abstract] [Full Text]
|
|
|
|
|
|
H. HOSHINO, J. LOTVALL, B.-E. SKOOGH, and A. LINDEN Neutrophil Recruitment by Interleukin-17 into Rat Airways In Vivo . Role of Tachykinins Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1423 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Marceau, J. F. Hess, and D. R. Bachvarov The B1 Receptors for Kinins Pharmacol. Rev., September 1, 1998; 50(3): 357 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yang, L. Taylor, and P. Polgar Mechanisms in the Transcriptional Regulation of Bradykinin B1 Receptor Gene Expression. IDENTIFICATION OF A MINIMUM CELL-TYPE SPECIFIC ENHANCER J. Biol. Chem., April 24, 1998; 273(17): 10763 - 10770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Larrivee, D. R. Bachvarov, F. Houle, J. Landry, J. Huot, and F. Marceau Role of the Mitogen-Activated Protein Kinases in the Expression of the Kinin B1 Receptors Induced by Tissue Injury J. Immunol., February 1, 1998; 160(3): 1419 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Pesquero, R. C. Araujo, P. A. Heppenstall, C. L. Stucky, J. A. Silva Jr., T. Walther, S. M. Oliveira, J. L. Pesquero, A. C. M. Paiva, J. B. Calixto, et al. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors PNAS, July 5, 2000; 97(14): 8140 - 8145. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
