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The Journal of Immunology, Vol 156, Issue 1 146-152, Copyright © 1996 by American Association of Immunologists
ARTICLES |
JA Wilder, CY Koh and D Yuan
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Investigations into the role of NK cells in regulating Ab responses have yielded variable results, some suggesting that NK cells can down- regulate Ag-specific Ig production and others proposing an enhancing effect. These apparently inconsistent findings may stem partially from the specificity of reagents used in purifying cell populations and/or the nature of the in vitro systems used to study these events. We chose to investigate the ability of either resting or poly(I:C)-activated NK cells to alter an in vivo Ab response in mice given a T-independent (TNP-LPS) or T-dependent (TNP-keyhole limpet hemocyanin (KLH)) Ag. By using a more specific Ab, anti-NK-1.1, to deplete NK cells, we were able to clearly show that resting, endogenous NK cells do not affect either type of response, as measured by serum Ag-specific Ig levels quantitated by isotype-specific ELISA. In contrast, activation of NK cells by poly(I:C) increased Ag-specific IgC2a as well as IgG1 levels. Interestingly, only the effect on IgG2a production is reversible by depletion of NK cells.
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