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The Journal of Immunology, Vol 155, Issue 9 4139-4142, Copyright © 1995 by American Association of Immunologists

CUTTING EDGE

Inhibition of gamma delta T cell recognition by receptors for MHC class I molecules

H Nakajima, H Tomiyama and M Takiguchi
Department of Tumor Biology, University of Tokyo, Japan.

NK cells have receptors for MHC class I molecules that inhibit cytotoxicity against target cells. We show that recognition of gamma delta CTL is negatively regulated by receptors for MHC class I molecules. Cytolysis of C1R cells by gamma delta CTL clones was inhibited by the expression of polymorphic HLA class I molecules on target cells and was restored by blocking with anti-HLA class I mAb, suggesting the presence of inhibitory receptors for HLA class I molecules. The receptors for HLA class I molecules on gamma delta T cells were heterogenous. The immune responses to various Ags may be regulated via these inhibitory receptors on T cells and NK cells.


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