The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Constant, S.
Right arrow Articles by Bottomly, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Constant, S.
Right arrow Articles by Bottomly, K.

The Journal of Immunology, Vol 155, Issue 8 3734-3741, Copyright © 1995 by American Association of Immunologists

ARTICLES

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo

S Constant, N Schweitzer, J West, P Ranney and K Bottomly
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

The potential role of different subsets of APCs to stimulate naive CD4+ T cells to peptide and protein Ags in vivo was examined. Mice lacking B cells (microMT knockout mice) were impaired in their priming to protein but not peptide Ags, suggesting a requirement for B cells in priming to protein Ags in vivo. Experiments designed to determine the ability of splenic dendritic cells (DCs) and B lymphocytes to take up peptide or protein Ags in vivo demonstrated that peptide Ags were taken up preferentially by DCs, whereas proteins were taken up by Ag-specific B cells in vivo. A further examination of the Ag-specific B cells pulsed in vivo with protein Ags revealed a marked up-regulation in surface expression of B7-2 costimulatory molecules, detectable as early as 4 h after Ag administration. Based on their potency in the uptake and processing of protein Ags as well as their ability to up-regulate costimulatory molecules through Ag internalization, we suggest that Ag- specific B cells will be an important APC in priming naive CD4+ T cells to protein Ags in vivo.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
F. Hjelm, M. C. I. Karlsson, and B. Heyman
A Novel B Cell-Mediated Transport of IgE-Immune Complexes to the Follicle of the Spleen
J. Immunol., May 15, 2008; 180(10): 6604 - 6610.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. K. O'Neill, Y. Cao, K. M. Hamel, P. D. Doodes, G. Hutas, and A. Finnegan
Expression of CD80/86 on B Cells Is Essential for Autoreactive T Cell Activation and the Development of Arthritis
J. Immunol., October 15, 2007; 179(8): 5109 - 5116.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. T. Hagymasi, A. M. Slaiby, M. A. Mihalyo, H. Z. Qui, D. J. Zammit, L. Lefrancois, and A. J. Adler
Steady State Dendritic Cells Present Parenchymal Self-Antigen and Contribute to, but Are Not Essential for, Tolerization of Naive and Th1 Effector CD4 Cells
J. Immunol., August 1, 2007; 179(3): 1524 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
N. D. Huntington, R. Tomioka, C. Clavarino, A. M. Chow, D. Linares, P. Mana, J. Rossjohn, T. G. Cachero, F. Qian, S. L. Kalled, et al.
A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses
Int. Immunol., October 1, 2006; 18(10): 1473 - 1485.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Lauterbach, A. Gruber, C. Ried, C. Cheminay, and T. Brocker
Insufficient APC Capacities of Dendritic Cells in Gene Gun-Mediated DNA Vaccination.
J. Immunol., April 15, 2006; 176(8): 4600 - 4607.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Getahun, F. Hjelm, and B. Heyman
IgE Enhances Antibody and T Cell Responses In Vivo via CD23+ B Cells
J. Immunol., August 1, 2005; 175(3): 1473 - 1482.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. M. Arnaboldi, M. J. Behr, and D. W. Metzger
Mucosal B Cell Deficiency in IgA-/- Mice Abrogates the Development of Allergic Lung Inflammation
J. Immunol., July 15, 2005; 175(2): 1276 - 1285.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Hon, A. Oran, T. Brocker, and J. Jacob
B Lymphocytes Participate in Cross-Presentation of Antigen following Gene Gun Vaccination
J. Immunol., May 1, 2005; 174(9): 5233 - 5242.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. K. O'Neill, M. J. Shlomchik, T. T. Glant, Y. Cao, P. D. Doodes, and A. Finnegan
Antigen-Specific B Cells Are Required as APCs and Autoantibody-Producing Cells for Induction of Severe Autoimmune Arthritis
J. Immunol., March 15, 2005; 174(6): 3781 - 3788.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. A. Byersdorfer, R. J. DiPaolo, S. J. Petzold, and E. R. Unanue
Following Immunization Antigen Becomes Concentrated in a Limited Number of APCs Including B Cells
J. Immunol., December 1, 2004; 173(11): 6627 - 6634.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Palena, M. Zhu, J. Schlom, and K.-Y. Tsang
Human B cells that hyperexpress a triad of costimulatory molecules via avipox-vector infection: an alternative source of efficient antigen-presenting cells
Blood, July 1, 2004; 104(1): 192 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Gerloni, M. Rizzi, P. Castiglioni, and M. Zanetti
T cell immunity using transgenic B lymphocytes
PNAS, March 16, 2004; 101(11): 3892 - 3897.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Heit, K. M. Huster, F. Schmitz, M. Schiemann, D. H. Busch, and H. Wagner
CpG-DNA Aided Cross-Priming by Cross-Presenting B Cells
J. Immunol., February 1, 2004; 172(3): 1501 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Attanavanich and J. F. Kearney
Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells
J. Immunol., January 15, 2004; 172(2): 803 - 811.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Ugrinovic, N. Menager, N. Goh, and P. Mastroeni
Characterization and Development of T-Cell Immune Responses in B-Cell-Deficient (Igh-6-/-) Mice with Salmonella enterica Serovar TyphimuriumInfection
Infect. Immun., December 1, 2003; 71(12): 6808 - 6819.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Jacquemin, V. Vantomme, C. Buhot, R. Lavend'homme, W. Burny, N. Demotte, P. Chaux, K. Peerlinck, J. Vermylen, B. Maillere, et al.
CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A
Blood, February 15, 2003; 101(4): 1351 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
P. Castiglioni, C. Lu, D. Lo, M. Croft, P. Langlade-Demoyen, M. Zanetti, and M. Gerloni
CD4 T cell priming in dendritic cell-deficient mice
Int. Immunol., January 1, 2003; 15(1): 127 - 136.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. Yan and M. J. Mamula
B and T cell tolerance and autoimmunity in autoantibody transgenic mice
Int. Immunol., August 1, 2002; 14(8): 963 - 971.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Shirota, K. Sano, N. Hirasawa, T. Terui, K. Ohuchi, T. Hattori, and G. Tamura
B Cells Capturing Antigen Conjugated with CpG Oligodeoxynucleotides Induce Th1 Cells by Elaborating IL-12
J. Immunol., July 15, 2002; 169(2): 787 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
D. C. Tsitoura, V. P. Yeung, R. H. DeKruyff, and D. T. Umetsu
Critical role of B cells in the development of T cell tolerance to aeroallergens
Int. Immunol., June 1, 2002; 14(6): 659 - 667.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. P. L. Chiu, A. M. Jevnikar, and J. S. Danska
Genetic Control of T and B Lymphocyte Activation in Nonobese Diabetic Mice
J. Immunol., December 15, 2001; 167(12): 7169 - 7179.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Rivera, C.-C. Chen, N. Ron, J. P. Dougherty, and Y. Ron
Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations
Int. Immunol., December 1, 2001; 13(12): 1583 - 1593.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Tian, D. Zekzer, L. Hanssen, Y. Lu, A. Olcott, and D. L. Kaufman
Lipopolysaccharide-Activated B Cells Down-Regulate Th1 Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic Mice
J. Immunol., July 15, 2001; 167(2): 1081 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. M. Blackwell and K. J. Else
B Cells and Antibodies Are Required for Resistance to the Parasitic Gastrointestinal Nematode Trichuris muris
Infect. Immun., June 1, 2001; 69(6): 3860 - 3868.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. O. Nashar, Z. E. Betteridge, and R. N. Mitchell
Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4+ T cells
Int. Immunol., April 1, 2001; 13(4): 541 - 551.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. P.L. Chiu, D. V. Serreze, and J. S. Danska
Development and Function of Diabetogenic T-cells in B-cell-Deficient Nonobese Diabetic Mice
Diabetes, April 1, 2001; 50(4): 763 - 770.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
H. Braley-Mullen and S. Yu
Early Requirement for B Cells for Development of Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice
J. Immunol., December 15, 2000; 165(12): 7262 - 7269.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P.-J. Linton, J. Harbertson, and L. M. Bradley
A Critical Role for B Cells in the Development of Memory CD4 Cells
J. Immunol., November 15, 2000; 165(10): 5558 - 5565.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Holz, T. Dyrberg, W. Hagopian, D. Homann, M. v. Herrath, and M. B. A. Oldstone
Neither B Lymphocytes Nor Antibodies Directed Against Self Antigens of the Islets of Langerhans Are Required for Development of Virus-Induced Autoimmune Diabetes
J. Immunol., November 15, 2000; 165(10): 5945 - 5953.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Muthukkumar, J. Goldstein, and K. E. Stein
The Ability of B Cells and Dendritic Cells to Present Antigen Increases During Ontogeny
J. Immunol., November 1, 2000; 165(9): 4803 - 4813.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Manickasingham and C. Reis e Sousa
Microbial and T Cell-Derived Stimuli Regulate Antigen Presentation by Dendritic Cells In Vivo
J. Immunol., November 1, 2000; 165(9): 5027 - 5034.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. P. Deshpande, M. Zheng, M. Daheshia, and B. T. Rouse
Pathogenesis of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions in B-Cell-Deficient Mice
J. Virol., April 15, 2000; 74(8): 3517 - 3524.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. E. Ozaki, B. A. Coren, T. N. Huynh, D. J. Redondo, H. Kikutani, and S. R. Webb
CD4+ T Cell Responses to CD40-Deficient APCs: Defects in Proliferation and Negative Selection Apply Only with B Cells as APCs
J. Immunol., November 15, 1999; 163(10): 5250 - 5256.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. L. Elkins, C. M. Bosio, and T. R. Rhinehart-Jones
Importance of B cells, but Not Specific Antibodies, in Primary and Secondary Protective Immunity to the Intracellular Bacterium Francisella tularensis Live Vaccine Strain
Infect. Immun., November 1, 1999; 67(11): 6002 - 6007.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. E. Coffin, S. L. Clark, N. A. Bos, J. O. Brubaker, and P. A. Offit
Migration of Antigen-Presenting B Cells from Peripheral to Mucosal Lymphoid Tissues May Induce Intestinal Antigen-Specific IgA Following Parenteral Immunization
J. Immunol., September 15, 1999; 163(6): 3064 - 3070.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Noorchashm, Y. K. Lieu, N. Noorchashm, S. Y. Rostami, S. A. S. Greeley, A. Schlachterman, H. K. Song, L. E. Noto, A. M. Jevnikar, C. F. Barker, et al.
I-Ag7-Mediated Antigen Presentation by B Lymphocytes Is Critical in Overcoming a Checkpoint in T Cell Tolerance to Islet {beta} Cells of Nonobese Diabetic Mice
J. Immunol., July 15, 1999; 163(2): 743 - 750.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Shinde, R. Gee, S. Santulli-Marotto, L. K. Bockenstedt, S. H. Clarke, and M. J. Mamula
T Cell Autoimmunity in Ig Transgenic Mice
J. Immunol., June 15, 1999; 162(12): 7519 - 7524.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Reis e Sousa and R. N. Germain
Analysis of Adjuvant Function by Direct Visualization of Antigen Presentation In Vivo: Endotoxin Promotes Accumulation of Antigen-Bearing Dendritic Cells in the T Cell Areas of Lymphoid Tissue
J. Immunol., June 1, 1999; 162(11): 6552 - 6561.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
O. T.M. Chan, L. G. Hannum, A. M. Haberman, M. P. Madaio, and M. J. Shlomchik
A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus
J. Exp. Med., May 17, 1999; 189(10): 1639 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. L. Constant
B Lymphocytes as Antigen-Presenting Cells for CD4+ T Cell Priming In Vivo
J. Immunol., May 15, 1999; 162(10): 5695 - 5703.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. P. Wong, C. Y. Okada, and R. Levy
TCR Vaccines Against T Cell Lymphoma: QS-21 and IL-12 Adjuvants Induce a Protective CD8+ T Cell Response
J. Immunol., February 15, 1999; 162(4): 2251 - 2258.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Kretz-Rommel and R. L. Rubin
Persistence of Autoreactive T Cell Drive Is Required to Elicit Anti-Chromatin Antibodies in a Murine Model of Drug-Induced Lupus
J. Immunol., January 15, 1999; 162(2): 813 - 820.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Jankovic, T. A. Wynn, M. C. Kullberg, S. Hieny, P. Caspar, S. James, A. W. Cheever, and A. Sher
Optimal Vaccination Against Schistosoma mansoni Requires the Induction of Both B Cell- and IFN-{gamma}-Dependent Effector Mechanisms
J. Immunol., January 1, 1999; 162(1): 345 - 351.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. V. Serreze, S. A. Fleming, H. D. Chapman, S. D. Richard, E. H. Leiter, and R. M. Tisch
B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice
J. Immunol., October 15, 1998; 161(8): 3912 - 3918.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
J. C. Rathmell, S. Fournier, B. C. Weintraub, J. P. Allison, and C. C. Goodnow
Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells
J. Exp. Med., August 17, 1998; 188(4): 651 - 659.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Desmedt, P. Rottiers, H. Dooms, W. Fiers, and J. Grooten
Macrophages Induce Cellular Immunity by Activating Th1 Cell Responses and Suppressing Th2 Cell Responses
J. Immunol., June 1, 1998; 160(11): 5300 - 5308.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. Jankovic, A. W. Cheever, M. C. Kullberg, T. A. Wynn, G. Yap, P. Caspar, F. A. Lewis, R. Clynes, J. V. Ravetch, and A. Sher
CD4+ T Cell-mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell-dependent Mechanism Requiring Fc Receptor Signaling
J. Exp. Med., February 16, 1998; 187(4): 619 - 629.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Gapin, Y. Bravo de Alba, A. Casrouge, J. P. Cabaniols, P. Kourilsky, and J. Kanellopoulos
Antigen Presentation by Dendritic Cells Focuses T Cell Responses Against Immunodominant Peptides: Studies in the Hen Egg-White Lysozyme (HEL) Model1
J. Immunol., February 15, 1998; 160(4): 1555 - 1564.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. E. Macaulay, R. H. DeKruyff, and D. T. Umetsu
Antigen-Primed T Cells from B Cell-Deficient JHD Mice Fail to Provide B Cell Help
J. Immunol., February 15, 1998; 160(4): 1694 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. H. G. Mills, M. Ryan, E. Ryan, and B. P. Mahon
A Murine Model in Which Protection Correlates with Pertussis Vaccine Efficacy in Children Reveals Complementary Roles for Humoral and Cell-Mediated Immunity in Protection against Bordetella pertussis
Infect. Immun., February 1, 1998; 66(2): 594 - 602.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Pasare, V. Morafo, M. Entringer, P. Bansal, A. George, V. Bal, S. Rath, and J. M. Durdik
Presence of Activated Antigen-Binding B Cells During Immunization Enhances Relative Levels of IFN-{gamma} in T Cell Responses
J. Immunol., January 15, 1998; 160(2): 778 - 787.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. Chan and M. J. Shlomchik
A New Role for B Cells in Systemic Autoimmunity: B Cells Promote Spontaneous T Cell Activation in MRL-lpr/lpr Mice
J. Immunol., January 1, 1998; 160(1): 51 - 59.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Steel and T. B. Nutman
Helminth Antigens Selectively Differentiate Unsensitized CD45RA+CD4+ Human T Cells in Vitro
J. Immunol., January 1, 1998; 160(1): 351 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. R. Milich, M. Chen, F. Schodel, D. L. Peterson, J. E. Jones, and J. L. Hughes
Role of B cells in antigen presentation of the hepatitis B core
PNAS, December 23, 1997; 94(26): 14648 - 14653.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
G. Zhong, C. R. e Sousa, and R. N. Germain
Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen-Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro
J. Exp. Med., August 29, 1997; 186(5): 673 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. Korsgren, J. S. E. alt, O. Korsgren, F. Sundler, and C. G.A. Persson
Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell-deficient Mice
J. Exp. Med., March 3, 1997; 185(5): 885 - 892.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. D. Wolf, B. N. Dittel, F. Hardardottir, and C. A. Janeway Jr.
Experimental Autoimmune Encephalomyelitis Induction in Genetically B Cell-deficient Mice
J. Exp. Med., December 15, 1996; 184(6): 2271 - 2278.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.