| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 155, Issue 8 3722-3725, Copyright © 1995 by American Association of Immunologists
ARTICLES |
Z Wang, JG Karras, RG Howard and TL Rothstein
Department of Medicine, Boston University Medical Center, MA 02118, USA.
CD40L, a membrane protein of activated T cells, interacts with the B cell receptor CD40. This interaction has been implicated in the rescue of germinal center B cells from apoptosis and in the rescue of WEHI-231 B lymphoma cells from sIg-induced apoptosis. In this report, we have demonstrated that the signal mediated by CD40L acts upon bcl-x, a bcl-2 homologue. bcl-x expression is strongly enhanced by CD40 receptor engagement, while there is little or no induction by sIg cross-linking. The expression of bax and bcl-2 is not significantly affected by either CD40L or sIg cross-linking. Antisense but not sense phosphorothioate oligonucleotide for bcl-x can partially block this CD40-mediated apoptotic rescue. This result suggests that the up-regulation of bcl-x by CD40L plays an important role in CD40-mediated apoptotic rescue in murine B cells.
This article has been cited by other articles:
|
|
 |
|
  T. Ashworth and A. L. Roy Cutting Edge: TFII-I Controls B Cell Proliferation via Regulating NF-{kappa}B J. Immunol., March 1, 2007; 178(5): 2631 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Smit, D. Y.H. Hallaert, R. Spijker, B. de Goeij, A. Jaspers, A. P. Kater, M. H.J. van Oers, C. J.M. van Noesel, and E. Eldering Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity Blood, February 15, 2007; 109(4): 1660 - 1668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Schwulst, M. H. Grayson, P. J. DiPasco, C. G. Davis, T. S. Brahmbhatt, T. A. Ferguson, and R. S. Hotchkiss Agonistic Monoclonal Antibody Against CD40 Receptor Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis J. Immunol., July 1, 2006; 177(1): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Masaki, M. Izumi, Y. Oshima, Y. Nakaoka, T. Kuroda, R. Kimura, S. Sugiyama, K. Terai, M. Kitakaze, K. Yamauchi-Takihara, et al. Smad1 Protects Cardiomyocytes From Ischemia-Reperfusion Injury Circulation, May 31, 2005; 111(21): 2752 - 2759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Gricks, D. Zahrieh, A. J. Zauls, G. Gorgun, D. Drandi, K. Mauerer, D. Neuberg, and J. G. Gribben Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells Blood, December 15, 2004; 104(13): 4002 - 4009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. McGregor, S. P. Schoenberger, and E. A. Green CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes PNAS, June 22, 2004; 101(25): 9345 - 9350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Guilbault and R. J. Kay RasGRP1 Sensitizes an Immature B Cell Line to Antigen Receptor-induced Apoptosis J. Biol. Chem., May 7, 2004; 279(19): 19523 - 19530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Minami, K. Yamamoto, H. Kiyoi, R. Ueda, H. Saito, and T. Naoe Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia Blood, October 15, 2003; 102(8): 2969 - 2975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hase, Y. Kanno, H. Kojima, C. Morimoto, K. Okumura, and T. Kobata CD27 and CD40 Inhibit p53-independent Mitochondrial Pathways in Apoptosis of B Cells Induced by B Cell Receptor Ligation J. Biol. Chem., November 27, 2002; 277(49): 46950 - 46958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nopora and T. Brocker Bcl-2 Controls Dendritic Cell Longevity In Vivo J. Immunol., September 15, 2002; 169(6): 3006 - 3014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. M. Mackus, S. M. A. Lens, R. H. Medema, M. J. Kwakkenbos, L. M. Evers, M. H. J. v. Oers, R. A. W. v. Lier, and E. Eldering Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation Int. Immunol., September 1, 2002; 14(9): 973 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Pedersen, S. Kitada, L. M. Leoni, J. M. Zapata, J. G. Karras, N. Tsukada, T. J. Kipps, Y. S. Choi, F. Bennett, and J. C. Reed Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1 Blood, August 13, 2002; 100(5): 1795 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Martinez-Barnetche, V. Madrid-Marina, R. A. Flavell, and J. Moreno Does CD40 Ligation Induce B Cell Negative Selection? J. Immunol., February 1, 2002; 168(3): 1042 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Zhu, L. M. Ramirez, R. L. Lee, N. S. Magnuson, G. A. Bishop, and M. R. Gold CD40 Signaling in B Cells Regulates the Expression of the Pim-1 Kinase Via the NF-{kappa}B Pathway J. Immunol., January 15, 2002; 168(2): 744 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jiang and E. A. Clark Involvement of Bik, a Proapoptotic Member of the Bcl-2 Family, in Surface IgM-Mediated B Cell Apoptosis J. Immunol., May 15, 2001; 166(10): 6025 - 6033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. BRAS, A. RUIZ-VELA, D. GARCIA-DOMINGO, and C. MARTINEZ-A Apoptosis as a Scaffold for Building up the B Cell Repertoire Ann. N.Y. Acad. Sci., December 1, 2000; 926(1): 13 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Andjelic, C. Hsia, H. Suzuki, T. Kadowaki, S. Koyasu, and H.-C. Liou Phosphatidylinositol 3-Kinase and NF-{kappa}B/Rel Are at the Divergence of CD40-Mediated Proliferation and Survival Pathways J. Immunol., October 1, 2000; 165(7): 3860 - 3867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lukin, M. Cosyns, T. Mitchell, M. Saffry, and A. Hayward Eradication of Cryptosporidium parvum Infection by Mice with Ovalbumin-Specific T Cells Infect. Immun., May 1, 2000; 68(5): 2663 - 2670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Green, F. S. Wong, K. Eshima, C. Mora, and R. A. Flavell Neonatal Tumor Necrosis Factor {alpha} Promotes Diabetes in Nonobese Diabetic Mice by CD154-independent Antigen Presentation to CD8+ T Cells J. Exp. Med., January 17, 2000; 191(2): 225 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Taylor, J. A. Hickman, and C. Dive Epigenetic Determinants of Resistance to Etoposide Regulation of Bcl-xL and Bax by Tumor Microenvironmental Factors J Natl Cancer Inst, January 5, 2000; 92(1): 18 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Donjerkovic, L. Zhang, and D. W. Scott Regulation of p27Kip1 Accumulation in Murine B-Lymphoma Cells: Role of c-Myc and Calcium Cell Growth Differ., October 1, 1999; 10(10): 695 - 704. [Abstract] [Full Text]
|
|
|
|
|
|
H. H. Lee, H. Dadgostar, Q. Cheng, J. Shu, and G. Cheng NF-kappa B-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes PNAS, August 3, 1999; 96(16): 9136 - 9141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Roberts and E. C. Snow Cutting Edge: Recruitment of the CD19/CD21 Coreceptor to B Cell Antigen Receptor Is Required for Antigen-Mediated Expression of Bcl-2 by Resting and Cycling Hen Egg Lysozyme Transgenic B Cells J. Immunol., April 15, 1999; 162(8): 4377 - 4380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Allison Green and R. A. Flavell TRANCE-RANK, a New Signal Pathway Involved in Lymphocyte Development and T Cell Activation J. Exp. Med., April 5, 1999; 189(7): 1017 - 1020. [Full Text] [PDF]
|
|
|
|
|
|
M. Tamatani, Y. H. Che, H. Matsuzaki, S. Ogawa, H. Okado, S.-i. Miyake, T. Mizuno, and M. Tohyama Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFkappa B Activation in Primary Hippocampal Neurons J. Biol. Chem., March 26, 1999; 274(13): 8531 - 8538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Craxton, G. Shu, J. D. Graves, J. Saklatvala, E. G. Krebs, and E. A. Clark p38 MAPK Is Required for CD40-Induced Gene Expression and Proliferation in B Lymphocytes J. Immunol., October 1, 1998; 161(7): 3225 - 3236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Lee and G. A. Koretzky Extracellular Signal-Regulated Kinase-2, But Not c-Jun NH2-Terminal Kinase, Activation Correlates with Surface IgM-Mediated Apoptosis in the WEHI 231 B Cell Line J. Immunol., August 15, 1998; 161(4): 1637 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gardby, P. Lane, and N. Y. Lycke Requirements for B7-CD28 Costimulation in Mucosal IgA Responses: Paradoxes Observed in CTLA4-H{gamma}1 Transgenic Mice J. Immunol., July 1, 1998; 161(1): 49 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-K. Yi, M. Chang, D. W. Peckham, A. M. Krieg, and R. F. Ashman CpG Oligodeoxyribonucleotides Rescue Mature Spleen B Cells from Spontaneous Apoptosis and Promote Cell Cycle Entry J. Immunol., June 15, 1998; 160(12): 5898 - 5906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Schauer, R. E. Bellas, and G. E. Sonenshein Dominant Signals Leading to Inhibitor {kappa}B Protein Degradation Mediate CD40 Ligand Rescue of WEHI 231 Immature B Cells from Receptor-Mediated Apoptosis J. Immunol., May 1, 1998; 160(9): 4398 - 4405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Plumas, M.-C. Jacob, L. Chaperot, J.-P. Molens, J.-J. Sotto, and J.-C. Bensa Tumor B Cells From Non-Hodgkin's Lymphoma Are Resistant to CD95 (Fas/Apo-1)-Mediated Apoptosis Blood, April 15, 1998; 91(8): 2875 - 2885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Messineo, M. H. Jamerson, E. Hunter, R. Braziel, A. Bagg, S. G. Irving, and J. Cossman Gene Expression by Single Reed-Sternberg Cells: Pathways of Apoptosis and Activation Blood, April 1, 1998; 91(7): 2443 - 2451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ramamoorthy and I. R. Tizard Induction of Apoptosis in a Macrophage Cell Line RAW 264.7 By Acemannan, a beta -(1,4)-Acetylated Mannan Mol. Pharmacol., March 1, 1998; 53(3): 415 - 421. [Abstract] [Full Text]
|
|
|
|
|
|
B. R. Wong, R. Josien, S. Y. Lee, B. Sauter, H.-L. Li, R. M. Steinman, and Y. Choi TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell-specific Survival Factor J. Exp. Med., December 15, 1997; 186(12): 2075 - 2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Rodeck, M. Jost, J. DuHadaway, C. Kari, P. J. Jensen, B. Risse, and D. L. Ewert Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor PNAS, May 13, 1997; 94(10): 5067 - 5072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Izumi, Y. Fujio, K. Kunisada, S. Negoro, E. Tone, M. Funamoto, T. Osugi, Y. Oshima, Y. Nakaoka, T. Kishimoto, et al. Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway J. Biol. Chem., August 10, 2001; 276(33): 31133 - 31141. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
