| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 155, Issue 7 3556-3562, Copyright © 1995 by American Association of Immunologists
ARTICLES |
Y Kawakami, L Yao, M Tashiro, S Gibson, GB Mills and T Kawakami
Division of Immunobiology, La Jolla Institute for Allergy and Immunology, CA 92037, USA.
Cross-linking of the high-affinity IgE receptor (Fc epsilon RI) on mast cells induces rapid phosphorylation on serine, threonine, and tyrosine residues and increases the enzymatic activity, of a Tec subfamily tyrosine kinase, Itk/Tsk/Emt (Emt). The pleckstrin homology domain of Emt at its amino-terminal interacts directly with multiple isoforms of protein kinase C (PKC) in vitro. In addition, a portion of Emt is physically associated with multiple isoforms of PKC in intact mast cells. PKC phosphorylates a bacterial fusion protein containing the pleckstrin homology domain of Emt in vitro. Coexpression of Emt in COS- 7 cells with Ca(2+)-dependent PKC isoforms (alpha, beta I, or beta II) induces an enhancement in tyrosine phosphorylation of Emt. In vivo inhibition of PKC expression or activity attenuates tyrosine phosphorylation and enzymatic activity of Emt induced upon Fc epsilon RI cross-linking. These data collectively suggest that PKC phosphorylates Emt and activates its autophosphorylating activity. Alternatively, PKC could activate another tyrosine kinase that phosphorylates Emt, or PKC-mediated phosphorylation of Emt may render it a target for another tyrosine kinase. In any case, PKC appears to play a major role in the activation of Emt induced upon Fc epsilon RI cross-linking.
This article has been cited by other articles:
|
|
 |
|
  C. Spatuzza, M. Schiavone, E. Di Salle, E. Janda, M. Sardiello, G. Fiume, O. Fierro, M. Simonetta, N. Argiriou, R. Faraonio, et al. Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk Nucleic Acids Res., August 1, 2008; 36(13): 4402 - 4416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Iyer and A. August The Tec Family Kinase, IL-2-Inducible T Cell Kinase, Differentially Controls Mast Cell Responses J. Immunol., June 15, 2008; 180(12): 7869 - 7877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Au-Yeung and D. J. Fowell A Key Role for Itk in Both IFN{gamma} and IL-4 Production by NKT Cells J. Immunol., July 1, 2007; 179(1): 111 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Khurana, L. N. Arneson, R. A. Schoon, C. J. Dick, and P. J. Leibson Differential Regulation of Human NK Cell-Mediated Cytotoxicity by the Tyrosine Kinase Itk J. Immunol., March 15, 2007; 178(6): 3575 - 3582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Forssell, P. Sideras, C. Eriksson, M. Malm-Erjefalt, K. Rydell-Tormanen, P.-O. Ericsson, and J. S. Erjefalt Interleukin-2-Inducible T Cell Kinase Regulates Mast Cell Degranulation and Acute Allergic Responses Am. J. Respir. Cell Mol. Biol., June 1, 2005; 32(6): 511 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Tkaczyk, V. Horejsi, S. Iwaki, P. Draber, L. E. Samelson, A. B. Satterthwaite, D.-H. Nahm, D. D. Metcalfe, and A. M. Gilfillan NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc{epsilon}RI aggregation Blood, July 1, 2004; 104(1): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ito, T. Yokomizo, T. Sasaki, H. Kurosu, J. Penninger, Y. Kanaho, T. Katada, K. Hanaoka, and T. Shimizu Requirement of Phosphatidylinositol 3-Kinase Activation and Calcium Influx for Leukotriene B4-induced Enzyme Release J. Biol. Chem., November 15, 2002; 277(47): 44898 - 44904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Perez-Villar, K. O'Day, D. H. Hewgill, S. G. Nadler, and S. B. Kanner Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin {alpha} (Rch1{alpha}) Int. Immunol., October 1, 2001; 13(10): 1265 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, C. Graham, V. Parravicini, M. J. Brown, J. Rivera, and S. Shaw Protein kinase C {theta} is expressed in mast cells and is functionally involved in Fc{varepsilon} receptor I signaling J. Leukoc. Biol., May 1, 2001; 69(5): 831 - 840. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y.-T. Tsai, Y.-H. Su, S.-S. Fang, T.-N. Huang, Y. Qiu, Y.-S. Jou, H.-m. Shih, H.-J. Kung, and R.-H. Chen Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation Mol. Cell. Biol., March 15, 2000; 20(6): 2043 - 2054. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. Perez-Villar and S. B. Kanner Regulated Association Between the Tyrosine Kinase Emt/Itk/Tsk and Phospholipase-C{gamma}1 in Human T Lymphocytes J. Immunol., December 15, 1999; 163(12): 6435 - 6441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Ching, Y. Kawakami, T. Kawakami, and C. D. Tsoukas Emt/Itk Associates with Activated TCR Complexes: Role of the Pleckstrin Homology Domain J. Immunol., December 1, 1999; 163(11): 6006 - 6013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yao, P. Janmey, L. G. Frigeri, W. Han, J. Fujita, Y. Kawakami, J. R. Apgar, and T. Kawakami Pleckstrin Homology Domains Interact with Filamentous Actin J. Biol. Chem., July 9, 1999; 274(28): 19752 - 19761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kawakami, S. E. Hartman, E. Kinoshita, H. Suzuki, J. Kitaura, L. Yao, N. Inagaki, A. Franco, D. Hata, M. Maeda-Yamamoto, et al. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase PNAS, March 2, 1999; 96(5): 2227 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ishizuka, K. Chayama, K. Takeda, E. Hamelmann, N. Terada, G. M. Keller, G. L. Johnson, and E. W. Gelfand Mitogen-Activated Protein Kinase Activation Through Fc{epsilon} Receptor I and Stem Cell Factor Receptor Is Differentially Regulated by Phosphatidylinositol 3-Kinase and Calcineurin in Mouse Bone Marrow-Derived Mast Cells J. Immunol., February 15, 1999; 162(4): 2087 - 2094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Debnath, M. Chamorro, M. J. Czar, E. M. Schaeffer, M. J. Lenardo, H. E. Varmus, and P. L. Schwartzberg rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases Mol. Cell. Biol., February 1, 1999; 19(2): 1498 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Yang, M. Ghiotto, B. Barbarat, and D. Olive The Role of Tec Protein-tyrosine Kinase in T Cell Signaling J. Biol. Chem., January 8, 1999; 274(2): 607 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lu, B. Cuevas, S. Gibson, H. Khan, R. LaPushin, J. Imboden, and G. B. Mills Phosphatidylinositol 3-Kinase Is Required for CD28 But Not CD3 Regulation of the TEC Family Tyrosine Kinase EMT/ITK/TSK: Functional and Physical Interaction of EMT with Phosphatidylinositol 3-Kinase J. Immunol., November 15, 1998; 161(10): 5404 - 5412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kawakami, S. E. Hartman, P. M. Holland, J. A. Cooper, and T. Kawakami Multiple Signaling Pathways for the Activation of JNK in Mast Cells: Involvement of Bruton's Tyrosine Kinase, Protein Kinase C, and JNK Kinases, SEK1 and MKK7 J. Immunol., August 15, 1998; 161(4): 1795 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hata, J. Kitaura, S. E. Hartman, Y. Kawakami, T. Yokota, and T. Kawakami Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells. DEPENDENCE ON THE c-Jun N-TERMINAL KINASE ACTIVATION PATHWAY J. Biol. Chem., May 1, 1998; 273(18): 10979 - 10987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hata, Y. Kawakami, N. Inagaki, C. S. Lantz, T. Kitamura, W. N. Khan, M. Maeda-Yamamoto, T. Miura, W. Han, S. E. Hartman, et al. Involvement of Bruton's Tyrosine Kinase in Fcepsilon RI-dependent Mast Cell Degranulation and Cytokine Production J. Exp. Med., April 20, 1998; 187(8): 1235 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Csonga, E. E. Prieschl, D. Jaksche, V. Novotny, and T. Baumruker Common and Distinct Signaling Pathways Mediate the Induction of TNF-{alpha} and IL-5 in IgE Plus Antigen-Stimulated Mast Cells J. Immunol., January 1, 1998; 160(1): 273 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Weil, M.-A. Power, S. I. Smith, and C. Leung Li Predominant Expression of Murine Bmx Tyrosine Kinase in the Granulo-Monocytic Lineage Blood, December 1, 1997; 90(11): 4332 - 4340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Saharinen, N. Ekman, K. Sarvas, P. Parker, K. Alitalo, and O. Silvennoinen The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cdelta Blood, December 1, 1997; 90(11): 4341 - 4353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Fleming, E. Donnadieu, C. H. Song, F. V. Laethem, S. J. Galli, and J.-P. Kinet Negative Regulation of Fcepsilon RI-mediated Degranulation by CD81 J. Exp. Med., October 20, 1997; 186(8): 1307 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. August, A. Sadra, B. Dupont, and H. Hanafusa Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase PNAS, October 14, 1997; 94(21): 11227 - 11232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Walker, C Girardet, and J. Habener Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis J. Biol. Chem., August 1, 1996; 271(33): 20145 - 20150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gibson, A. August, D. Branch, B. Dupont, and G. B. Mills Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK J. Biol. Chem., March 22, 1996; 271(12): 7079 - 7083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. von Lindern, M. P.-v. Amelsvoort, T. van Dijk, E. Deiner, E. van den Akker, S. van Emst-de Vries, P. Willems, H. Beug, and B. Lowenberg Protein Kinase C alpha Controls Erythropoietin Receptor Signaling J. Biol. Chem., October 27, 2000; 275(44): 34719 - 34727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Jui, R.-J. Tseng, X. Wen, H.-I Fang, L.-M. Huang, K.-Y. Chen, H.-J. Kung, D. K. Ann, and H.-M. Shih Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases J. Biol. Chem., December 22, 2000; 275(52): 41124 - 41132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kawakami, J. Kitaura, S. E. Hartman, C. A. Lowell, R. P. Siraganian, and T. Kawakami Regulation of protein kinase Cbeta I by two protein-tyrosine kinases, Btk and Syk PNAS, June 20, 2000; 97(13): 7423 - 7428. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
