The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fehsel, K.
Right arrow Articles by Kolb-Bachofen, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fehsel, K.
Right arrow Articles by Kolb-Bachofen, V.

The Journal of Immunology, Vol 155, Issue 6 2858-2865, Copyright © 1995 by American Association of Immunologists

ARTICLES

Nitric oxide induces apoptosis in mouse thymocytes

K Fehsel, KD Kroncke, KL Meyer, H Huber, V Wahn and V Kolb-Bachofen
Institute of Immunobiology, Heinrich Heine University, Dusseldorf, Germany.

Nitric oxide (NO) produced at high concentrations by the inducible NO synthase is an important effector molecule involved in immune regulation and defense. We have examined whether NO represents a signal for triggering apoptosis in thymocytes. Freshly isolated thymocytes were incubated with different chemical NO donors for various intervals. Apoptosis was determined by detection of DNA strand breaks with in situ nick translation. All NO donors induced thymocyte apoptosis with 30% positive thymocytes vs 10% in controls after 8 h. Apoptosis was prevented by addition of ZnSO4. Short-term pre-exposure to NO resulted in protection from apoptosis induced by glucocorticoids comparable with the protective effect of heat shock. Flow cytometry revealed that NO treatment as well as heat shock or dexamethasone incubation is accompanied by reduction in the CD4+ CD8+ thymocyte subpopulation. Apoptosis induction was accompanied by increased expression of p53, as detected by PCR analysis 2 h after NO donor addition. In vivo treatment of mice with endotoxin results in increased thymic apoptosis. Focal apoptosis was found to occur in close proximity to blood vessels 18 h after LPS treatment. Capillary endothelium and dendritic cells adjacent to apoptotic foci were found to stain strongly for inducible NO synthase expression. Furthermore, in an in vitro experiment using cocultures of thymocytes with LPS/cytokine-activated endothelial cells expressing inducible NO synthase, a significantly increased rate of thymocyte apoptosis was found, and this could be prevented completely by inhibiting NO production. Addition of dexamethasone to these cocultures did not lead to a further increase in the percentage of apoptotic thymocytes, underlining the protective effect of NO on dexamethasone-induced apoptosis.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
J. Hong, Y. Nakano, A. Yokomakura, K. Ishihara, S. Kim, Y.-S. Kang, and K. Ohuchi
Nitric Oxide Production by the Vacuolar-Type (H+)-ATPase Inhibitors Bafilomycin A1 and Concanamycin A and Its Possible Role in Apoptosis in RAW 264.7 Cells
J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 672 - 681.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. M. Marriott, P. G. Hellewell, S. S. Cross, P. G. Ince, M. K. B. Whyte, and D. H. Dockrell
Decreased Alveolar Macrophage Apoptosis Is Associated with Increased Pulmonary Inflammation in a Murine Model of Pneumococcal Pneumonia
J. Immunol., November 1, 2006; 177(9): 6480 - 6488.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Yoshioka, T. Kitao, T. Kishino, A. Yamamuro, and S. Maeda
Nitric oxide protects macrophages from hydrogen peroxide-induced apoptosis by inducing the formation of catalase.
J. Immunol., April 15, 2006; 176(8): 4675 - 4681.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. M. McLaughlin and B. Demple
Nitric Oxide-Induced Apoptosis in Lymphoblastoid and Fibroblast Cells Dependent on the Phosphorylation and Activation of p53
Cancer Res., July 15, 2005; 65(14): 6097 - 6104.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
B. P. Olivieri, D. A. Farias-De-Oliveira, T. C. Araujo-Jorge, and V. Cotta-de-Almeida
Benznidazole Therapy in Trypanosoma cruzi-Infected Mice Blocks Thymic Involution and Apoptosis of CD4+CD8+ Double-Positive Thymocytes
Antimicrob. Agents Chemother., May 1, 2005; 49(5): 1981 - 1987.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. Hong, A. Yokomakura, Y. Nakano, H. S. Ban, K. Ishihara, J.-W. Ahn, O. Zee, and K. Ohuchi
Induction of Nitric Oxide Production by the Cytostatic Macrolide Apicularen A [2,4-Heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 Dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and Possible Role of Nitric Oxide in Apicularen A-Induced Apoptosis in RAW 264.7 Cells
J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 968 - 977.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. M. Jeong, K. Y. Lee, D. Shin, H. Chung, S. H. Jeon, and R. H. Seong
Nitric Oxide Inhibits Glucocorticoid-induced Apoptosis of Thymocytes by Repressing the SRG3 Expression
J. Biol. Chem., August 13, 2004; 279(33): 34373 - 34379.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. L. Goodwin, L. P. Solomonson, and D. C. Eichler
Argininosuccinate Synthase Expression Is Required to Maintain Nitric Oxide Production and Cell Viability in Aortic Endothelial Cells
J. Biol. Chem., April 30, 2004; 279(18): 18353 - 18360.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. O. Velardez, A. H. Poliandri, J. P. Cabilla, C. C. A. Bodo, L. I. Machiavelli, and B. H. Duvilanski
Long-Term Treatment of Anterior Pituitary Cells with Nitric Oxide Induces Programmed Cell Death
Endocrinology, April 1, 2004; 145(4): 2064 - 2070.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
R. M. Slim, Yunling Song, M. Albassam, and L. A. Dethloff
Apoptosis and Nitrative Stress Associated with Phosphodiesterase Inhibitor-Induced Mesenteric Vasculitis in Rats
Toxicol Pathol, October 1, 2003; 31(6): 638 - 645.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
T. A. Miura, K. Morris, S. Ryan, J. L. Cook, and J. M. Routes
Adenovirus E1A, Not Human Papillomavirus E7, Sensitizes Tumor Cells to Lysis by Macrophages Through Nitric Oxide- and TNF-{alpha}-Dependent Mechanisms Despite Up-Regulation of 70-kDa Heat Shock Protein
J. Immunol., April 15, 2003; 170(8): 4119 - 4126.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T.-A. Kim, H. K. Avraham, Y.-H. Koh, S. Jiang, I.-W. Park, and S. Avraham
HIV-1 Tat-Mediated Apoptosis in Human Brain Microvascular Endothelial Cells
J. Immunol., March 1, 2003; 170(5): 2629 - 2637.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. AMON, M. D. MENGER, and B. VOLLMAR
Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-{alpha}-induced microcirculatory dysfunction and apoptotic cell death
FASEB J, February 1, 2003; 17(2): 175 - 185.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. V. Suschek, E. Bonmann, A. Kapsokefalou, K. Hemmrich, H. Kleinert, U. Forstermann, K.-D. Kroncke, C. Mahotka, and V. Kolb-Bachofen
Revisiting an Old Antimicrobial Drug: Amphotericin B Induces Interleukin-1-Converting Enzyme as the Main Factor for Inducible Nitric-Oxide Synthase Expression in Activated Endothelia
Mol. Pharmacol., October 1, 2002; 62(4): 936 - 946.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. V. Beligni, A. Fath, P. C. Bethke, L. Lamattina, and R. L. Jones
Nitric Oxide Acts as an Antioxidant and Delays Programmed Cell Death in Barley Aleurone Layers
Plant Physiology, August 1, 2002; 129(4): 1642 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Heigold, C. Sers, W. Bechtel, B. Ivanovas, R. Schafer, and G. Bauer
Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts
Carcinogenesis, June 1, 2002; 23(6): 929 - 941.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
W. M. HON, K. H. LEE, and H. E. KHOO
Nitric Oxide in Liver Diseases: Friend, Foe, or Just Passerby?
Ann. N.Y. Acad. Sci., May 1, 2002; 962(1): 275 - 295.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. Marchetti, S. Ulisse, S. Bruscoli, F. P. Russo, G. Migliorati, F. Schiaffella, M. G. Cifone, C. Riccardi, and R. Fringuelli
Induction of Apoptosis by 1,4-Benzothiazine Analogs in Mouse Thymocytes
J. Pharmacol. Exp. Ther., March 1, 2002; 300(3): 1053 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
P. Dickie, A. Roberts, and R. Lee
A defect in HIV-1 transgenic murine macrophages results in deficient nitric oxide production
J. Leukoc. Biol., October 1, 2001; 70(4): 592 - 600.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. A. Gordon, W. Abou-Jaoude, R. A. Hoffman, S. A. McCarthy, Y.-M. Kim, X. Zhou, X.-R. Zhang, R. L. Simmons, Y. Chen, L. Schall, et al.
Nitric oxide induces murine thymocyte apoptosis by oxidative injury and a p53-dependent mechanism
J. Leukoc. Biol., July 1, 2001; 70(1): 87 - 95.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. He, Y. Xiao, and L. Zhang
Cocaine-Mediated Apoptosis in Bovine Coronary Artery Endothelial Cells: Role of Nitric Oxide
J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 180 - 187.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
S. Pervin, R. Singh, C.-L. Gau, H. Edamatsu, F. Tamanoi, and G. Chaudhuri
Potentiation of Nitric Oxide-induced Apoptosis of MDA-MB-468 Cells by Farnesyltransferase Inhibitor: Implications in Breast Cancer
Cancer Res., June 1, 2001; 61(12): 4701 - 4706.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Moulian, F. Truffault, Y. M. Gaudry-Talarmain, A. Serraf, and S. Berrih-Aknin
In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation
Blood, June 1, 2001; 97(11): 3521 - 3530.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L.-Y. Xu, J.-S. Yang, H. Link, and B.-G. Xiao
SIN-1, a Nitric Oxide Donor, Ameliorates Experimental Allergic Encephalomyelitis in Lewis Rats in the Incipient Phase: The Importance of the Time Window
J. Immunol., May 1, 2001; 166(9): 5810 - 5816.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. R. Murphy, M. Limoges, F. Dodd, R. T. M. Boudreau, and C. K. L. Too
Fibroblast Growth Factor-2 Stimulates Endothelial Nitric Oxide Synthase Expression and Inhibits Apoptosis by a Nitric Oxide-Dependent Pathway in Nb2 Lymphoma Cells
Endocrinology, January 1, 2001; 142(1): 81 - 88.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S Chikano, K Sawada, T Shimoyama, S-I Kashiwamura, A Sugihara, K Sekikawa, N Terada, K Nakanishi, and H Okamura
IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner
Gut, December 1, 2000; 47(6): 779 - 786.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. S. Cauley, E. E. Miller, M. Yen, and S. L. Swain
Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-{gamma}
J. Immunol., December 1, 2000; 165(11): 6056 - 6066.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. A. O'Connor, J. S. Jenson, and E. Devaney
NO Contributes to Proliferative Suppression in a Murine Model of Filariasis
Infect. Immun., November 1, 2000; 68(11): 6101 - 6107.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zhou, S. A. Gordon, Y.-M. Kim, R. A. Hoffman, Y. Chen, X.-R. Zhang, R. L. Simmons, and H. R. Ford
Nitric Oxide Induces Thymocyte Apoptosis Via a Caspase-1-Dependent Mechanism
J. Immunol., August 1, 2000; 165(3): 1252 - 1258.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Xaus, M. Comalada, A. F. Valledor, J. Lloberas, F. Lopez-Soriano, J. M. Argiles, C. Bogdan, and A. Celada
LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha
Blood, June 15, 2000; 95(12): 3823 - 3831.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Shi, Q. Xiong, B. Wang, X. Le, N. A. Khan, and K. Xie
Influence of Nitric Oxide Synthase II Gene Disruption on Tumor Growth and Metastasis
Cancer Res., May 1, 2000; 60(10): 2579 - 2583.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
S. Aiello, M. Noris, G. Piccinini, S. Tomasoni, F. Casiraghi, S. Bonazzola, M. Mister, M. H. Sayegh, and G. Remuzzi
Thymic Dendritic Cells Express Inducible Nitric Oxide Synthase and Generate Nitric Oxide in Response to Self- and Alloantigens
J. Immunol., May 1, 2000; 164(9): 4649 - 4658.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Shichiri, M. Yokokura, F. Marumo, and Y. Hirata
Endothelin-1 Inhibits Apoptosis of Vascular Smooth Muscle Cells Induced by Nitric Oxide and Serum Deprivation via MAP Kinase Pathway
Arterioscler. Thromb. Vasc. Biol., April 1, 2000; 20(4): 989 - 997.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
I. Angulo, F. G. de las Heras, J. F. Garcia-Bustos, D. Gargallo, M. A. Munoz-Fernandez, and M. Fresno
Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+ cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice
Blood, January 1, 2000; 95(1): 212 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H.-Y. Zhang and S. H. Phan
Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor beta 1
Am. J. Respir. Cell Mol. Biol., December 1, 1999; 21(6): 658 - 665.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. E. Paz-Miguel, R. Flores, P. Sanchez-Velasco, G. Ocejo-Vinyals, J. Escribano de Diego, J. Lopez de Rego, and F. Leyva-Cobian
Reactive Oxygen Intermediates During Programmed Cell Death Induced in the Thymus of the Ts(1716)65Dn Mouse, a Murine Model for Human Down's Syndrome
J. Immunol., November 15, 1999; 163(10): 5399 - 5410.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
C. Bartholdy, A. Nansen, J. E. Christensen, O. Marker, and A. R. Thomsen
Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology
J. Gen. Virol., November 1, 1999; 80(11): 2997 - 3005.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
A. Allione, P. Bernabei, M. Bosticardo, S. Ariotti, G. Forni, and F. Novelli
Nitric Oxide Suppresses Human T Lymphocyte Proliferation Through IFN-{gamma}-Dependent and IFN-{gamma}-Independent Induction of Apoptosis
J. Immunol., October 15, 1999; 163(8): 4182 - 4191.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. A. Martins, L. Q. Vieira, F. Q. Cunha, and J. S. Silva
Gamma Interferon Modulates CD95 (Fas) and CD95 Ligand (Fas-L) Expression and Nitric Oxide-Induced Apoptosis during the Acute Phase of Trypanosoma cruzi Infection: a Possible Role in Immune Response Control
Infect. Immun., August 1, 1999; 67(8): 3864 - 3871.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. K. Srivastava, S. J. Sollott, L. Khan, R. Hansford, E. G. Lakatta, and D. L. Longo
Bcl-2 and Bcl-XL Block Thapsigargin-Induced Nitric Oxide Generation, c-Jun NH2-Terminal Kinase Activity, and Apoptosis
Mol. Cell. Biol., August 1, 1999; 19(8): 5659 - 5674.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Ina, J. Itoh, K. Fukushima, K. Kusugami, T. Yamaguchi, K. Kyokane, A. Imada, D. G. Binion, A. Musso, G. A. West, et al.
Resistance of Crohn's Disease T Cells to Multiple Apoptotic Signals Is Associated with a Bcl-2/Bax Mucosal Imbalance
J. Immunol., July 15, 1999; 163(2): 1081 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Glockzin, A. von Knethen, M. Scheffner, and B. Brune
Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome
J. Biol. Chem., July 9, 1999; 274(28): 19581 - 19586.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Nabeshima, M. Nomoto, G. Matsuzaki, K. Kishihara, H. Taniguchi, S.-i. Yoshida, and K. Nomoto
T-Cell Hyporesponsiveness Induced by Activated Macrophages through Nitric Oxide Production in Mice Infected with Mycobacterium tuberculosis
Infect. Immun., July 1, 1999; 67(7): 3221 - 3226.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Wright, G. Kolios, J. Westwick, and S. G. Ward
Cytokine-induced Apoptosis in Epithelial HT-29 Cells Is Independent of Nitric Oxide Formation. EVIDENCE FOR AN INTERLEUKIN-13-DRIVEN PHOSPHATIDYLINOSITOL 3-KINASE-DEPENDENT SURVIVAL MECHANISM
J. Biol. Chem., June 11, 1999; 274(24): 17193 - 17201.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Takeda, M. Tashima, A. Takahashi, T. Uchiyama, and T. Okazaki
Ceramide Generation in Nitric Oxide-induced Apoptosis. ACTIVATION OF MAGNESIUM-DEPENDENT NEUTRAL SPHINGOMYELINASE VIA CASPASE-3
J. Biol. Chem., April 9, 1999; 274(15): 10654 - 10660.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Ushmorov, F. Ratter, V. Lehmann, W. Droge, V. Schirrmacher, and V. Umansky
Nitric Oxide-Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release
Blood, April 1, 1999; 93(7): 2342 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. Adams, H. Jiang, J. Yu, S. Mobius-Winkler, E. Fiehn, A. Linke, C. Weigl, G. Schuler, and R. Hambrecht
Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance
J. Am. Coll. Cardiol., March 15, 1999; 33(4): 959 - 965.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Huwiler, J. Pfeilschifter, and H. van den Bosch
Nitric Oxide Donors Induce Stress Signaling via Ceramide Formation in Rat Renal Mesangial Cells
J. Biol. Chem., March 12, 1999; 274(11): 7190 - 7195.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. V. Suschek, V. Krischel, D. Bruch-Gerharz, D. Berendji, J. Krutmann, K.-D. Kroncke, and V. Kolb-Bachofen
Nitric Oxide Fully Protects against UVA-induced Apoptosis in Tight Correlation with Bcl-2 Up-regulation
J. Biol. Chem., March 5, 1999; 274(10): 6130 - 6137.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Y.-M. Kim, C. A. Bombeck, and T. R. Billiar
Nitric Oxide as a Bifunctional Regulator of Apoptosis
Circ. Res., February 19, 1999; 84(3): 253 - 256.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. Suenobu, M. Shichiri, M. Iwashina, F. Marumo, and Y. Hirata
Natriuretic Peptides and Nitric Oxide Induce Endothelial Apoptosis via a cGMP–Dependent Mechanism
Arterioscler. Thromb. Vasc. Biol., January 1, 1999; 19(1): 140 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Williams, S. Noguchi, P. A. Henkart, and Y. Osawa
Nitric Oxide Synthase Plays a Signaling Role in TCR-Triggered Apoptotic Death
J. Immunol., December 15, 1998; 161(12): 6526 - 6531.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. A. Wu-Hsieh, W. Chen, and H.-J. Lee
Nitric Oxide Synthase Expression in Macrophages of Histoplasma capsulatum-Infected Mice Is Associated with Splenocyte Apoptosis and Unresponsiveness
Infect. Immun., November 1, 1998; 66(11): 5520 - 5526.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. D. Ceneviva, E. Tzeng, D. G. Hoyt, E. Yee, A. Gallagher, J. F. Engelhardt, Y.-M. Kim, T. R. Billiar, S. A. Watkins, and B. R. Pitt
Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells
Am J Physiol Lung Cell Mol Physiol, October 1, 1998; 275(4): L717 - L728.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Ambs, M. O. Ogunfusika, W. G. Merriam, W. P. Bennett, T. R. Billiar, and C. C. Harris
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice
PNAS, July 21, 1998; 95(15): 8823 - 8828.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
L. Virág, G. Haskó, A. L. Salzman, and C. Szabó
NADPH Diaphorase Histochemistry Detects Inducible Nitric Oxide Synthetase Activity in the Thymus of Naive and Staphylococcal Enterotoxin B-stimulated Mice
J. Histochem. Cytochem., July 1, 1998; 46(7): 787 - 792.
[Abstract] [Full Text]

Home page
 BloodHome page
K. Chlichlia, M. E. Peter, M. Rocha, C. Scaffidi, M. Bucur, P. H. Krammer, V. Schirrmacher, and V. Umansky
Caspase Activation Is Required for Nitric Oxide-Mediated, CD95(APO-1/Fas)-Dependent and Independent Apoptosis in Human Neoplastic Lymphoid Cells
Blood, June 1, 1998; 91(11): 4311 - 4320.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Fernandez-Gomez, S. Esteban, R. Gomez-Corvera, K. Zoulika, and A. Ouaissi
Trypanosoma cruzi: Tc52 Released Protein-Induced Increased Expression of Nitric Oxide Synthase and Nitric Oxide Production by Macrophages
J. Immunol., April 1, 1998; 160(7): 3471 - 3479.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Okada, H. Zhang, M. Hatano, and T. Tokuhisa
A Physiologic Role of Bcl-xL Induced in Activated Macrophages
J. Immunol., March 15, 1998; 160(6): 2590 - 2596.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-M. Kim, R. V. Talanian, and T. R. Billiar
Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms
J. Biol. Chem., December 5, 1997; 272(49): 31138 - 31148.
[Abstract] [Full Text] [PDF]

Home page
 </