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The Journal of Immunology, Vol 155, Issue 6 2808-2811, Copyright © 1995 by American Association of Immunologists

CUTTING EDGE

Requirement for extrathymic class I histocompatibility antigens for positive selection of thymus-derived T lymphocytes

B Fuller and L Lefrancois
Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington 06030, USA.

We have examined whether the thymus can produce immature T cell precursors for subsequent positive selection in the periphery. Using the intestine as a model system, we demonstrate that extrathymic MHC class I molecules positively select thymus-derived TCR-alpha beta CD8+ intestinal intraepithelial lymphocytes. Grafting of MHC class I+ thymus onto MHC class I- hosts resulted in the generation of donor and host- derived CD4-CD8+ T cells in lymph node, but few TCR-alpha beta CD4-CD8+ intraepithelial lymphocytes. The results indicate that the intestine can act as a site of positive selection for thymus-derived T cells. Bone marrow reconstitution studies demonstrated that non-hematopoietic, radiation-resistant cells, perhaps intestinal epithelial cells, were responsible for extrathymic positive selection of thymus-derived T cells. These findings demonstrate that the thymus can support organ- specific immunity via provision of targeted precursor populations.


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