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The Journal of Immunology, Vol 155, Issue 5 2515-2524, Copyright © 1995 by American Association of Immunologists

ARTICLES

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection

JL Flynn, MM Goldstein, KJ Triebold, J Sypek, S Wolf and BR Bloom
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

IL-12, a cytokine produced by macrophages and B cells, has recently been found to exert pleiotropic effects on the immune system. When BALB/c mice, a strain highly susceptible to virulent Mycobacterium tuberculosis infection, were given IL-12 at the initiation of infection with M. tuberculosis, their mean survival time doubled from 58 to 112 days. IL-12-treated mice had diminished bacterial burdens, whereas treatment with exogenous IFN-gamma had no effect on survival or bacterial burden. IL-12 treatment also delayed lung pathology in BALB/c mice. In contrast with the findings in the BALB/c model, IL-12 did not increase survival of M. tuberculosis-infected gko mice, transgenic mice in which the IFN-gamma gene has been disrupted, indicating that IL-12 does not induce protection against tuberculosis in mice in the absence of IFN-gamma.


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