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The Journal of Immunology, Vol 155, Issue 4 2047-2056, Copyright © 1995 by American Association of Immunologists
ARTICLES |
A Mukasa, K Hiromatsu, G Matsuzaki, R O'Brien, W Born and K Nomoto
Department of Immunology, Kyushu University, Fukuoka, Japan.
The mechanisms that lead to the breakdown of self-tolerance and testis- specific immune reactivity in the murine orchitis model are understood only in part. We investigated the histopathologic and immunologic consequences of a unilateral bacterial (Listeria monocytogenes) infection of the testis. Both infected and contralateral sides of this bilateral organ suffered severe inflammatory responses despite a conspicuous absence of bacteria in the contralateral tissue. Also, in both testicles, T cell populations increased, involving both alpha beta and gamma delta T cell subsets. Concomitant with the bilateral orchitis, testis-specific delayed type hypersensitivity and Ab responses developed. Ab depletion experiments indicated that in this orchitis model, as in others, alpha beta T cells are initiators of the autoaggressive reactivity. In contrast, Ab depletion of gamma delta T cells accelerated the inflammatory response in both testicles, suggesting a regulatory role for this type of T cells in both infection- induced and autoimmune orchitis.
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