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The Journal of Immunology, Vol 155, Issue 3 1502-1514, Copyright © 1995 by American Association of Immunologists
ARTICLES |
SI Simon, AR Burns, AD Taylor, PK Gopalan, EB Lynam, LA Sklar and CW Smith
Speros P. Martel Section of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Emigration of leukocytes at sites of inflammation is initiated by the selectin family of carbohydrate-binding adhesion molecules. Molecular crossbridges initiate rolling of cells along the vascular endothelium where chemokines such as IL-8 and platelet activating factor (PAF) may be presented to their receptors on the leukocyte surface resulting in cell stimulation. Integrin activation appears to be a requirement for subsequent cell localization and diapedesis into the tissue. Several recent reports have demonstrated that ligation and cross-linking of neutrophil L-selectin results in neutrophil activation, including intracellular calcium release, superoxide production, and induction of mRNA for production of IL-8 and TNF-alpha. The purpose of this study was to examine whether ligation and cross-linking of L-selectin would specifically result in activation of beta 2-integrin-dependent adhesion. A fluorescence flow cytometric assay was developed that directly measures Mac-1-dependent cell adhesion. Fluorescent latex beads (2-microns diameter) were adsorbed with albumin or fibrinogen and added in excess to human neutrophils in a shear-stirred suspension. Following stimulation the kinetics of bead capture by neutrophils was continuously measured in real time on the flow cytometer. The onset of bead binding was detected in the presence of extremely low concentrations of PAF (10 pM) or formyl peptide (0.2 nM) stimulation. Ligation of L-selectin with whole IgG DREG200 or DREG56 Ab, but not controls (anti-CD44, -CD45, -CD11a), resulted in a significant potentiation of bead binding. Cross-linking F(ab')2 fragments of DREG200 with a goat anti-mouse F(ab')2 secondary Ab also stimulated beta 2-integrin-dependent adhesion in a dose-dependent fashion. A chimeric form of DREG200 expressing gamma 4 or gamma 1 isotypes of human Fc domain also stimulated cell adhesion when cross-linked. Surface expression of CD18 and an activation-dependent epitope, as detected with mAb24, also increased in response to L-selectin cross- linking. Cross-linking L-selectin induced significant adhesion and transmigration of neutrophils across human umbilical vein endothelial cells. We propose that cross-linking of L-selectin results in a cell signal that directly stimulates beta 2-integrin adhesive responses.
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S. Neelamegham, A. D. Taylor, A. R. Burns, C. W. Smith, and S. I. Simon Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1 Blood, September 1, 1998; 92(5): 1626 - 1638. [Abstract] [Full Text] [PDF]
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K. Konstantopoulos, S. Neelamegham, A. R. Burns, E. Hentzen, G. S. Kansas, K. R. Snapp, E. L. Berg, J. D. Hellums, C. W. Smith, L. V. McIntire, et al. Venous Levels of Shear Support Neutrophil-Platelet Adhesion and Neutrophil Aggregation in Blood via P-Selectin and ß2-Integrin Circulation, September 1, 1998; 98(9): 873 - 882. [Abstract] [Full Text] [PDF]
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M. Frey, N. B. Packianathan, T. A. Fehniger, M. E. Ross, W.-C. Wang, C. C. Stewart, M. A. Caligiuri, and S. S. Evans Differential Expression and Function of L-Selectin on CD56bright and CD56dim Natural Killer Cell Subsets J. Immunol., July 1, 1998; 161(1): 400 - 408. [Abstract] [Full Text] [PDF]
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O. Avni, Z. Pur, E. Yefenof, and M. Baniyash Complement Receptor 3 of Macrophages Is Associated with Galectin-1-Like Protein J. Immunol., June 15, 1998; 160(12): 6151 - 6158. [Abstract] [Full Text] [PDF]
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M. M. Mariscalco, M. H. Tcharmtchi, and C. W. Smith P-Selectin Support of Neonatal Neutrophil Adherence Under Flow: Contribution of L-Selectin, LFA-1, and Ligand(s) for P-Selectin Blood, June 15, 1998; 91(12): 4776 - 4785. [Abstract] [Full Text] [PDF]
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R. A. Newton and N. Hogg The Human S100 Protein MRP-14 Is a Novel Activator of the {beta}2 Integrin Mac-1 on Neutrophils J. Immunol., February 1, 1998; 160(3): 1427 - 1435. [Abstract] [Full Text] [PDF]
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M. W. Nicholson, A. N. Barclay, M. S. Singer, S. D. Rosen, and P. A. van der Merwe Affinity and Kinetic Analysis of L-selectin (CD62L) Binding to Glycosylation-dependent Cell-adhesion Molecule-1 J. Biol. Chem., January 9, 1998; 273(2): 763 - 770. [Abstract] [Full Text] [PDF]
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P.H.M. Kuijper, H.I. G. Torres, J.A.M. van der Linden, J.-W.J. Lammers, J.J. Sixma, J.J. Zwaginga, and L. Koenderman Neutrophil Adhesion to Fibrinogen and Fibrin Under Flow Conditions Is Diminished by Activation and L-Selectin Shedding Blood, March 15, 1997; 89(6): 2131 - 2138. [Abstract] [Full Text] [PDF]
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R. Mohle, M. A.S. Moore, R. L. Nachman, and S. Rafii Transendothelial Migration of CD34+ and Mature Hematopoietic Cells: An In Vitro Study Using a Human Bone Marrow Endothelial Cell Line Blood, January 1, 1997; 89(1): 72 - 80. [Abstract] [Full Text] [PDF]
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S. N. McGill, N. A. Ahmed, F. Hu, R. P. Michel, and N. V. Christou Shedding of L-Selectin as a Mechanism for Reduced Polymorphonuclear Neutrophil Exudation in Patients With the Systemic Inflammatory Response Syndrome Arch Surg, November 1, 1996; 131(11): 1141 - 1147. [Abstract] [PDF]
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J Ng-Sikorski, L Linden, D Eierman, L Franzen, L Molony, and T Andersson Engagement of L-selectin impairs the actin polymerizing capacity of beta 2-integrins on neutrophils J. Cell Sci., January 9, 1996; 109(9): 2361 - 2369. [Abstract] [PDF]
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J. E. Smolen, T. K. Petersen, C. Koch, S. J. O'Keefe, W. A. Hanlon, S. Seo, D. Pearson, M. C. Fossett, and S. I. Simon L-Selectin Signaling of Neutrophil Adhesion and Degranulation Involves p38 Mitogen-activated Protein Kinase J. Biol. Chem., May 19, 2000; 275(21): 15876 - 15884. [Abstract] [Full Text] [PDF]
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M.-H. Ruchaud-Sparagano, T. R. Walker, A. G. Rossi, C. Haslett, and I. Dransfield Soluble E-selectin Acts in Synergy with Platelet-activating Factor to Activate Neutrophil beta 2-Integrins. ROLE OF TYROSINE KINASES AND Ca2+ MOBILIZATION J. Biol. Chem., May 19, 2000; 275(21): 15758 - 15764. [Abstract] [Full Text] [PDF]
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