| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 155, Issue 3 1442-1449, Copyright © 1995 by American Association of Immunologists
ARTICLES |
AA Vaporciyan, MS Mulligan, JS Warren, PA Barton, M Miyasaka and PA Ward
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.
Intrapulmonary deposition of IgG immune complexes in rats causes acute inflammatory lung injury that is neutrophil, complement, cytokines (IL- 1, TNF-alpha), and intercellular adhesion molecule (ICAM-1) dependent. In the current studies involving the same model of lung injury, complement depletion or complement blockade resulted in substantial reductions in up-regulation of pulmonary vascular ICAM-1, accompanied by reduced lung injury and neutrophil accumulation. Complement depletion neither reduced the amount of immune complex deposited in lung nor the TNF-alpha content in bronchoalveolar lavage fluids. In the same model of inflammatory lung injury, neutrophil depletion (which is highly protective) did not affect up-regulation of lung vascular ICAM- 1. Up-regulation of lung vascular ICAM-1 by intratracheally administered TNF-alpha was also prevented by complement depletion. These studies indicate an unexpected in vivo relationship between complement and up-regulation of lung vascular ICAM-1.
This article has been cited by other articles:
|
|
 |
|
  Y. Banz, O. M. Hess, S. C. Robson, E. Csizmadia, D. Mettler, P. Meier, A. Haeberli, S. Shaw, R. A. Smith, and R. Rieben Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1 Cardiovasc Res, December 1, 2007; 76(3): 482 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Qiao, C. Atkinson, H. Song, R. Pannu, I. Singh, and S. Tomlinson Complement Plays an Important Role in Spinal Cord Injury and Represents a Therapeutic Target for Improving Recovery following Trauma Am. J. Pathol., September 1, 2006; 169(3): 1039 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Jha, J.-H. Sohn, Q. Xu, H. Nishihori, Y. Wang, S. Nishihori, B. Manickam, H. J. Kaplan, P. S. Bora, and N. S. Bora The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 1030 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. von Dobschuetz, O. Bleiziffer, S. Pahernik, M. Dellian, T. Hoffmann, and K. Messmer Soluble complement receptor 1 preserves endothelial barrier function and microcirculation in postischemic pancreatitis in the rat Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G791 - G796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-T. Lu, P.-G. Chen, and S. F. Liu Time course of lung ischemia-reperfusion-induced ICAM-1 expression and its role in ischemia-reperfusion lung injury J Appl Physiol, August 1, 2002; 93(2): 620 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao, M. C. Montalto, K. J. Pfeiffer, L. Hao, and G. L. Stahl Murine model of gastrointestinal ischemia associated with complement-dependent injury J Appl Physiol, July 1, 2002; 93(1): 338 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. K. Lagrand, H. W.M. Niessen, R. Nijmeijer, and C. E. Hack Role for Complement as an Intermediate Between C-Reactive Protein and Intercellular Adhesion Molecule-1 Expression? Circulation, August 28, 2001; 104 (9): e46 - e46. [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Brauer, C. Gegenfurtner, B. Neumann, M. Stadler, C. D. Heidecke, and B. Holzmann Endotoxin-Induced Lung Inflammation Is Independent of the Complement Membrane Attack Complex Infect. Immun., March 1, 2000; 68(3): 1626 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Bless, M. Huber-Lang, R.-F. Guo, R. L. Warner, H. Schmal, B. J. Czermak, T. P. Shanley, L. D. Crouch, A. B. Lentsch, V. Sarma, et al. Role of CC Chemokines (Macrophage Inflammatory Protein-1{beta}, Monocyte Chemoattractant Protein-1, RANTES) in Acute Lung Injury in Rats J. Immunol., March 1, 2000; 164(5): 2650 - 2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Henke, L. A. DeBrunye, R. M. Strieter, J. S. Bromberg, M. Prince, A. M. Kadell, M. Sarkar, F. Londy, and T. W. Wakefield Viral IL-10 Gene Transfer Decreases Inflammation and Cell Adhesion Molecule Expression in a Rat Model of Venous Thrombosis J. Immunol., February 15, 2000; 164(4): 2131 - 2141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Jarvis, J. Li, and K. V. Swanson Invasion of Human Mucosal Epithelial Cells by Neisseria gonorrhoeae Upregulates Expression of Intercellular Adhesion Molecule 1 (ICAM-1) Infect. Immun., March 1, 1999; 67(3): 1149 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Czermak, V. Sarma, N. M. Bless, H. Schmal, H. P. Friedl, and P. A. Ward In Vitro and In Vivo Dependency of Chemokine Generation on C5a and TNF-{alpha} J. Immunol., February 15, 1999; 162(4): 2321 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Tsuji, G. P. Geba, Y. Wang, K. Kawamoto, L. A. Matis, and P. W. Askenase Required Early Complement Activation in Contact Sensitivity with Generation of Local C5-dependent Chemotactic Activity, and Late T Cell Interferon gamma : A Possible Initiating Role of B Cells J. Exp. Med., October 6, 1997; 186(7): 1015 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tedesco, M. Pausa, E. Nardon, M. Introna, A. Mantovani, and A. Dobrina The Cytolytically Inactive Terminal Complement Complex Activates Endothelial Cells to Express Adhesion Molecules and Tissue Factor Procoagulant Activity J. Exp. Med., May 5, 1997; 185(9): 1619 - 1628. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
