| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 155, Issue 3 1304-1315, Copyright © 1995 by American Association of Immunologists
ARTICLES |
H Gan, GW Newman and HG Remold
Department of Rheumatology/Immunology, Brigham and Womens' Hospital, Boston, MA 02115, USA.
Although Mycobacterium avium is usually nonpathogenic in healthy individuals, in vitro infection of macrophages (M phi) from the majority of healthy donors induces death of the cells 2 wk after infection; this effect is in contrast to noninfected M phi, which survive for months in culture. We demonstrate here that treatment of normal M phi with indomethacin further shortens the life of these cells to 48 h after infection with M. avium. Indomethacin treatment of the M phi also prevents M. avium-dependent accumulation of mRNA-encoding plasminogen activator inhibitor type-2 (PAI-2), an inhibitor of urokinase-type plasminogen activator. Occurrence of nuclear condensation and DNA fragmentation in M phi pretreated with indomethacin and infected with M. avium indicates that the early death of these cells is caused by apoptosis. In contrast, priming of M phi with GM-CSF significantly prolongs their survival after M. avium infection and enhances M. avium-induced accumulation of PAI-2 mRNA. Most importantly, addition of PAI-2 is sufficient to prevent apoptosis of M phi infected with M. avium in the presence of indomethacin. Finally, M phi not treated with indomethacin also die of apoptosis 7 to 10 days after M. avium infection and can be rescued by PAI-2. These studies indicate that production of PAI-2 by normal M phi as a consequence of M. avium infection inhibits programmed cell death, a mechanism that might serve to prevent the spread of the infection.
This article has been cited by other articles:
|
|
 |
|
  L. Tonnetti, S. Netzel-Arnett, G. A. Darnell, T. Hayes, M. S. Buzza, I. E. Anglin, A. Suhrbier, and T. M. Antalis SerpinB2 Protection of Retinoblastoma Protein from Calpain Enhances Tumor Cell Survival Cancer Res., July 15, 2008; 68(14): 5648 - 5657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. O'Sullivan, S. O'Leary, D. M. Kelly, and J. Keane A Caspase-Independent Pathway Mediates Macrophage Cell Death in Response to Mycobacterium tuberculosis Infection Infect. Immun., April 1, 2007; 75(4): 1984 - 1993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cathelin, C. Rebe, L. Haddaoui, N. Simioni, F. Verdier, M. Fontenay, S. Launay, P. Mayeux, and E. Solary Identification of Proteins Cleaved Downstream of Caspase Activation in Monocytes Undergoing Macrophage Differentiation J. Biol. Chem., June 30, 2006; 281(26): 17779 - 17788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hamano, K. Tsukamoto, M. Abe, G. D. Sun, D. Zhang, H. Fujii, S. Matsuoka, M. Tanaka, A. Ishida-Okawara, H. Tachikawa, et al. Genetic Dissection of Vasculitis, Myeloperoxidase-Specific Antineutrophil Cytoplasmic Autoantibody Production, and Related Traits in Spontaneous Crescentic Glomerulonephritis-Forming/Kinjoh Mice J. Immunol., March 15, 2006; 176(6): 3662 - 3673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shi, G. Wei, W. Pan, and H. Tabel Impaired Kupffer Cells in Highly Susceptible Mice Infected with Trypanosoma congolense Infect. Immun., December 1, 2005; 73(12): 8393 - 8396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mullick, M. Elias, P. Harakidas, A. Marcil, M. Whiteway, B. Ge, T. J. Hudson, A. W. Caron, L. Bourget, S. Picard, et al. Gene Expression in HL60 Granulocytoids and Human Polymorphonuclear Leukocytes Exposed to Candida albicans{dagger} Infect. Immun., January 1, 2004; 72(1): 414 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qiao, S. Prabhakar, E. M. Coccia, M. Weiden, A. Canova, E. Giacomini, and R. Pine Host Defense Responses to Infection by Mycobacterium tuberculosis. INDUCTION OF IRF-1 AND A SERINE PROTEASE INHIBITOR J. Biol. Chem., June 14, 2002; 277(25): 22377 - 22385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brouard, P. O. Berberat, E. Tobiasch, M. P. Seldon, F. H. Bach, and M. P. Soares Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-kappa B to Protect Endothelial Cells from Tumor Necrosis Factor-alpha -mediated Apoptosis J. Biol. Chem., May 10, 2002; 277(20): 17950 - 17961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yu, F. Maurer, and R. L. Medcalf Plasminogen activator inhibitor type 2: a regulator of monocyte proliferation and differentiation Blood, April 15, 2002; 99(8): 2810 - 2818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Tse, S. I. Josephy, E. D. Chan, D. Fouts, and A. M. Cooper Activation of the Mitogen-Activated Protein Kinase Signaling Pathway Is Instrumental in Determining the Ability of Mycobacterium avium to Grow in Murine Macrophages J. Immunol., January 15, 2002; 168(2): 825 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Ogbourne and T. M. Antalis Characterisation of PAUSE-1, a powerful silencer in the human plasminogen activator inhibitor type 2 gene promoter Nucleic Acids Res., October 1, 2001; 29(19): 3919 - 3927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-M. Zhou, I. Bolon, A. Nichols, A. Wohlwend, and J.-D. Vassalli Overexpression of Plasminogen Activator Inhibitor Type 2 in Basal Keratinocytes Enhances Papilloma Formation in Transgenic Mice Cancer Res., February 1, 2001; 61(3): 970 - 976. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. M. Dougherty, J. M. Pearson, A. Y. Yang, R. J. Westrick, M. S. Baker, and D. Ginsburg The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival PNAS, January 19, 1999; 96(2): 686 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Balcewicz-Sablinska, J. Keane, H. Kornfeld, and H. G. Remold Pathogenic Mycobacterium tuberculosis Evades Apoptosis of Host Macrophages by Release of TNF-R2, Resulting in Inactivation of TNF-{alpha} J. Immunol., September 1, 1998; 161(5): 2636 - 2641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Antalis, M. La Linn, K. Donnan, L. Mateo, J. Gardner, J. L. Dickinson, K. Buttigieg, and A. Suhrbier The Serine Proteinase Inhibitor (Serpin) Plasminogen Activation Inhibitor Type 2 Protects against Viral Cytopathic Effects by Constitutive Interferon alpha /beta Priming J. Exp. Med., June 1, 1998; 187(11): 1799 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Maurer and R. L. Medcalf Plasminogen Activator Inhibitor Type 2Gene Induction by Tumor Necrosis Factor and Phorbol Ester Involves Transcriptional and Post-transcriptional Events. IDENTIFICATION OF A FUNCTIONAL NONAMERIC AU-RICH MOTIF IN THE 3prime -UNTRANSLATED REGION J. Biol. Chem., October 18, 1996; 271(42): 26074 - 26080. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
