The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Finbloom, D. S.
Right arrow Articles by Winestock, K. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Finbloom, D. S.
Right arrow Articles by Winestock, K. D.

The Journal of Immunology, Vol 155, Issue 3 1079-1090, Copyright © 1995 by American Association of Immunologists

ARTICLES

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes

DS Finbloom and KD Winestock
Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892-4555, USA.

IL-10 affects monocytes and T cells by driving the progression of immune responsiveness such that Th2 lymphocyte-mediated effects predominate. In this report, we show that in monocytes and T cells IL- 10 stimulates tyrosine phosphorylation of the signal transducers and activators of transcription, STAT1 alpha and STAT3, in a differential manner such that the relative formation of homo- and heterodimers varies between the two cell types. Moreover, monocytes express a novel IL-10-stimulated STAT protein with an M(r) of 70 kDa that is recognized by the anti-STAT3 Ab but is not observed in T cells. IL-10 treatment of both T cells and monocytes results in the ligand-induced tyrosine phosphorylation of tyk2 and Jak1, but not Jak2 or Jak3. Selective modulation of immune responsiveness by IL-10 in cells such as monocytes and T cells may result in part from the differential activation of STAT protein pairs.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Chakrabarti, A. J. Sadler, N. Kar, H. A. Young, R. H. Silverman, and B. R. G. Williams
Protein Kinase R-dependent Regulation of Interleukin-10 in Response to Double-stranded RNA
J. Biol. Chem., September 12, 2008; 283(37): 25132 - 25139.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Gagnon, S. Ramanathan, C. Leblanc, A. Cloutier, P. P. McDonald, and S. Ilangumaran
IL-6, in Synergy with IL-7 or IL-15, Stimulates TCR-Independent Proliferation and Functional Differentiation of CD8+ T Lymphocytes
J. Immunol., June 15, 2008; 180(12): 7958 - 7968.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Tokumasa, A. Suto, S.-i. Kagami, S. Furuta, K. Hirose, N. Watanabe, Y. Saito, K. Shimoda, I. Iwamoto, and H. Nakajima
Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-{gamma} production and the induction of Th1 cell differentiation
Blood, July 15, 2007; 110(2): 553 - 560.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. J. Staples, T. Smallie, L. M. Williams, A. Foey, B. Burke, B. M. J. Foxwell, and L. Ziegler-Heitbrock
IL-10 Induces IL-10 in Primary Human Monocyte-Derived Macrophages via the Transcription Factor Stat3
J. Immunol., April 15, 2007; 178(8): 4779 - 4785.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. M. Williams, U. Sarma, K. Willets, T. Smallie, F. Brennan, and B. M. J. Foxwell
Expression of Constitutively Active STAT3 Can Replicate the Cytokine-suppressive Activity of Interleukin-10 in Human Primary Macrophages
J. Biol. Chem., March 9, 2007; 282(10): 6965 - 6975.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. V. Spencer
The Cytomegalovirus Homolog of Interleukin-10 Requires Phosphatidylinositol 3-Kinase Activity for Inhibition of Cytokine Synthesis in Monocytes
J. Virol., February 15, 2007; 81(4): 2083 - 2086.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Kawakami, N. Inagaki, S. Salek-Ardakani, J. Kitaura, H. Tanaka, K. Nagao, Y. Kawakami, W. Xiao, H. Nagai, M. Croft, et al.
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3
PNAS, January 3, 2006; 103(1): 153 - 158.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. A. R. Rahimi, K. Gee, S. Mishra, W. Lim, and A. Kumar
STAT-1 Mediates the Stimulatory Effect of IL-10 on CD14 Expression in Human Monocytic Cells
J. Immunol., June 15, 2005; 174(12): 7823 - 7832.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. Grutz
New insights into the molecular mechanism of interleukin-10-mediated immunosuppression
J. Leukoc. Biol., January 1, 2005; 77(1): 3 - 15.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Roth, C. Sustmann, M. Kieslinger, A. Gilmozzi, D. Irmer, E. Kremmer, C. Turck, and R. Grosschedl
PIASy-Deficient Mice Display Modest Defects in IFN and Wnt Signaling
J. Immunol., November 15, 2004; 173(10): 6189 - 6199.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kamiya, T. Owaki, N. Morishima, F. Fukai, J. Mizuguchi, and T. Yoshimoto
An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells
J. Immunol., September 15, 2004; 173(6): 3871 - 3877.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. A. Ricchetti, L. M. Williams, and B. M. J. Foxwell
Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide
J. Leukoc. Biol., September 1, 2004; 76(3): 719 - 726.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. P. Donnelly, F. Sheikh, S. V. Kotenko, and H. Dickensheets
The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
J. Leukoc. Biol., August 1, 2004; 76(2): 314 - 321.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
M. E. Stearns, G. Kim, F. Garcia, and M. Wang
Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene Expression in Human Prostate CPTX-1532 Cells
Mol. Cancer Res., July 1, 2004; 2(7): 403 - 416.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
V. Barbarin, M. Arras, P. Misson, M. Delos, B. McGarry, S. H. Phan, D. Lison, and F. Huaux
Characterization of the Effect of Interleukin-10 on Silica-Induced Lung Fibrosis in Mice
Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 78 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Nishiki, F. Hato, N. Kamata, E. Sakamoto, T. Hasegawa, A. Kimura-Eto, M. Hino, and S. Kitagawa
Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-{alpha} production
Am J Physiol Cell Physiol, June 1, 2004; 286(6): C1302 - C1311.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. A. Shumilla, V. Lacaille, T. M. C. Hornell, J. Huang, S. Narasimhan, D. A. Relman, and E. D. Mellins
Bordetella pertussis Infection of Primary Human Monocytes Alters HLA-DR Expression
Infect. Immun., March 1, 2004; 72(3): 1450 - 1462.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Sredni, M. Weil, G. Khomenok, I. Lebenthal, S. Teitz, Y. Mardor, Z. Ram, A. Orenstein, A. Kershenovich, S. Michowiz, et al.
Ammonium Trichloro(dioxoethylene-o,o')tellurate (AS101) Sensitizes Tumors to Chemotherapy by Inhibiting the Tumor Interleukin 10 Autocrine Loop
Cancer Res., March 1, 2004; 64(5): 1843 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Williams, L. Bradley, A. Smith, and B. Foxwell
Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages
J. Immunol., January 1, 2004; 172(1): 567 - 576.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Herrero, X. Hu, W. P. Li, S. Samuels, M. N. Sharif, S. Kotenko, and L. B. Ivashkiv
Reprogramming of IL-10 Activity and Signaling by IFN-{gamma}
J. Immunol., November 15, 2003; 171(10): 5034 - 5041.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Biswas, S. Datta, J. D. Gupta, M. Novotny, J. Tebo, and T. A. Hamilton
Regulation of Chemokine mRNA Stability by Lipopolysaccharide and IL-10
J. Immunol., June 15, 2003; 170(12): 6202 - 6208.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J.-D. Ji, I. Tassiulas, K.-H. Park-Min, A. Aydin, I. Mecklenbrauker, A. Tarakhovsky, L. Pricop, J. E. Salmon, and L. B. Ivashkiv
Inhibition of Interleukin 10 Signaling after Fc Receptor Ligation and during Rheumatoid Arthritis
J. Exp. Med., June 2, 2003; 197(11): 1573 - 1583.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
K. Asadullah, W. Sterry, and H. D. Volk
Interleukin-10 Therapy--Review of a New Approach
Pharmacol. Rev., June 1, 2003; 55(2): 241 - 269.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Gasche, P. Grundtner, P. Zwirn, W. Reinisch, S. H. Shaw, A. Zdanov, U. Sarma, L. M. Williams, B. M. Foxwell, and A. Gangl
Novel Variants of the IL-10 Receptor 1 Affect Inhibition of Monocyte TNF-{alpha} Production
J. Immunol., June 1, 2003; 170(11): 5578 - 5582.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. V. Weinstock, A. Blum, A. Metwali, D. Elliott, and R. Arsenescu
IL-18 and IL-12 Signal Through the NF-{kappa}B Pathway to Induce NK-1R Expression on T Cells
J. Immunol., May 15, 2003; 170(10): 5003 - 5007.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Niemand, A. Nimmesgern, S. Haan, P. Fischer, F. Schaper, R. Rossaint, P. C. Heinrich, and G. Muller-Newen
Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3
J. Immunol., March 15, 2003; 170(6): 3263 - 3272.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Kalechman, B. Sredni, T. Weinstein, I. Freidkin, A. Tobar, M. Albeck, and U. Gafter
Production of the Novel Mesangial Autocrine Growth Factors GDNF and IL-10 Is Regulated by the Immunomodulator AS101
J. Am. Soc. Nephrol., March 1, 2003; 14(3): 620 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. E. Stearns, M. Wang, Y. Hu, F. U. Garcia, and J. Rhim
Interleukin 10 Blocks Matrix Metalloproteinase-2 and Membrane Type 1-Matrix Metalloproteinase Synthesis in Primary Human Prostate Tumor Lines
Clin. Cancer Res., March 1, 2003; 9(3): 1191 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Seto, H. Nakajima, A. Suto, K. Shimoda, Y. Saito, K. I. Nakayama, and I. Iwamoto
Enhanced Th2 Cell-Mediated Allergic Inflammation in Tyk2-Deficient Mice
J. Immunol., January 15, 2003; 170(2): 1077 - 1083.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A.-F. Petit-Bertron, C. Fitting, J.-M. Cavaillon, and M. Adib-Conquy
Adherence influences monocyte responsiveness to interleukin-10
J. Leukoc. Biol., January 1, 2003; 73(1): 145 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Alas and B. Bonavida
Inhibition of Constitutive STAT3 Activity Sensitizes Resistant Non-Hodgkin's Lymphoma and Multiple Myeloma to Chemotherapeutic Drug-mediated Apoptosis
Clin. Cancer Res., January 1, 2003; 9(1): 316 - 326.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. Ikeda, K. Sato, N. Kuwada, T. Matsumura, T. Yamashita, F. Kimura, K. Hatake, K. Ikeda, and K. Motoyoshi
Interleukin-10 differently regulates monocyte chemoattractant protein-1 gene expression depending on the environment in a human monoblastic cell line, UG3
J. Leukoc. Biol., December 1, 2002; 72(6): 1198 - 1205.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Williams, G. Jarai, A. Smith, and P. Finan
IL-10 expression profiling in human monocytes
J. Leukoc. Biol., October 1, 2002; 72(4): 800 - 809.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Lejeune, L. Dumoutier, S. Constantinescu, W. Kruijer, J. J. Schuringa, and J.-C. Renauld
Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line. PATHWAYS THAT ARE SHARED WITH AND DISTINCT FROM IL-10
J. Biol. Chem., September 6, 2002; 277(37): 33676 - 33682.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. C. Jones, N. J. Logsdon, K. Josephson, J. Cook, P. A. Barry, and M. R. Walter
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1
PNAS, July 9, 2002; 99(14): 9404 - 9409.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Ding, L. Qin, D. Zamarin, S. V. Kotenko, S. Pestka, K. W. Moore, and J. S. Bromberg
Differential IL-10R1 Expression Plays a Critical Role in IL-10-Mediated Immune Regulation
J. Immunol., December 15, 2001; 167(12): 6884 - 6892.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Tanuma, H. Shima, K. Nakamura, and K. Kikuchi
Protein tyrosine phosphatase epsilon C selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling
Blood, November 15, 2001; 98(10): 3030 - 3034.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-H. Zhou, S. R. Broussard, K. Strle, G. G. Freund, R. W. Johnson, R. Dantzer, and K. W. Kelley
IL-10 Inhibits Apoptosis of Promyeloid Cells by Activating Insulin Receptor Substrate-2 and Phosphatidylinositol 3'-Kinase
J. Immunol., October 15, 2001; 167(8): 4436 - 4442.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. Avdiushko, D. Hongo, H. Lake-Bullock, A. Kaplan, and D. Cohen
IL-10 receptor dysfunction in macrophages during chronic inflammation
J. Leukoc. Biol., October 1, 2001; 70(4): 624 - 632.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
P. Vigano, B. Gaffuri, E. Somigliana, M. Infantino, M. Vignali, and A.M. Di Blasio
Interleukin-10 is produced by human uterine natural killer cells but does not affect their production of interferon-{gamma}
Mol. Hum. Reprod., October 1, 2001; 7(10): 971 - 977.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-i. Hashimoto, I. Komuro, M. Yamada, and K. S. Akagawa
IL-10 Inhibits Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Human Monocyte Survival at the Early Stage of the Culture and Inhibits the Generation of Macrophages
J. Immunol., October 1, 2001; 167(7): 3619 - 3625.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Crepaldi, S. Gasperini, J. A. Lapinet, F. Calzetti, C. Pinardi, Y. Liu, S. Zurawski, R. de Waal Malefyt, K. W. Moore, and M. A. Cassatella
Up-Regulation of IL-10R1 Expression Is Required to Render Human Neutrophils Fully Responsive to IL-10
J. Immunol., August 15, 2001; 167(4): 2312 - 2322.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. K. Levings, R. Sangregorio, F. Galbiati, S. Squadrone, R. de Waal Malefyt, and M.-G. Roncarolo
IFN-{{alpha}} and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells
J. Immunol., May 1, 2001; 166(9): 5530 - 5539.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. Ameixa and J. S. Friedland
Down-Regulation of Interleukin-8 Secretion from Mycobacterium tuberculosis-Infected Monocytes by Interleukin-4 and -10 but Not by Interleukin-13
Infect. Immun., April 1, 2001; 69(4): 2470 - 2476.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Corinti, C. Albanesi, A. la Sala, S. Pastore, and G. Girolomoni
Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions
J. Immunol., April 1, 2001; 166(7): 4312 - 4318.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. T. Ahmed and L. B. Ivashkiv
Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways
J. Immunol., November 1, 2000; 165(9): 5227 - 5237.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A.-M. O'Farrell, D. A. Parry, F. Zindy, M. F. Roussel, E. Lees, K. W. Moore, and A. L.-F. Mui
Stat3-Dependent Induction of p19INK4D by IL-10 Contributes to Inhibition of Macrophage Proliferation
J. Immunol., May 1, 2000; 164(9): 4607 - 4615.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Josephson, R. DiGiacomo, S. R. Indelicato, A. H. Ayo, T. L. Nagabhushan, M. H. Parker, and M. R. Walter
Design and Analysis of an Engineered Human Interleukin-10 Monomer
J. Biol. Chem., April 28, 2000; 275(18): 13552 - 13557.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. A. Cassatella, S. Gasperini, C. Bovolenta, F. Calzetti, M. Vollebregt, P. Scapini, M. Marchi, R. Suzuki, A. Suzuki, and A. Yoshimura
Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10-Induced Pathway That Is Independent of STAT Protein Activation
Blood, October 15, 1999; 94(8): 2880 - 2889.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. K. Riley, K. Takeda, S. Akira, and R. D. Schreiber
Interleukin-10 Receptor Signaling through the JAK-STAT Pathway. REQUIREMENT FOR TWO DISTINCT RECEPTOR-DERIVED SIGNALS FOR ANTI-INFLAMMATORY ACTION
J. Biol. Chem., June 4, 1999; 274(23): 16513 - 16521.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Sato, H. Nagayama, K. Tadokoro, T. Juji, and T. A. Takahashi
Extracellular Signal-Regulated Kinase, Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase, and p38mapk Are Involved in IL-10-Mediated Selective Repression of TNF-{alpha}-Induced Activation and Maturation of Human Peripheral Blood Monocyte-Derived Dendritic Cells
J. Immunol., April 1, 1999; 162(7): 3865 - 3872.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Thivierge, J.-L. Parent, J. Stankova, and M. Rola-Pleszczynski
Modulation of Formyl Peptide Receptor Expression by IL-10 in Human Monocytes and Neutrophils
J. Immunol., March 15, 1999; 162(6): 3590 - 3595.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Kishore, J. M. Tebo, M. Kolosov, and T. A. Hamilton
Cutting Edge: Clustered AU-Rich Elements Are the Target of IL-10-Mediated mRNA Destabilization in Mouse Macrophages
J. Immunol., March 1, 1999; 162(5): 2457 - 2461.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Ito, P. Ansari, M. Sakatsume, H. Dickensheets, N. Vazquez, R. P. Donnelly, A. C. Larner, and D. S. Finbloom
Interleukin-10 Inhibits Expression of Both Interferon alpha - and Interferon gamma - Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1
Blood, March 1, 1999; 93(5): 1456 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Suttles, D. M. Milhorn, R. W. Miller, J. C. Poe, L. M. Wahl, and R. D. Stout
CD40 Signaling of Monocyte Inflammatory Cytokine Synthesis through an ERK1/2-dependent Pathway. A TARGET OF INTERLEUKIN ()-4 AND IL-10 ANTI-INFLAMMATORY ACTION
J. Biol. Chem., February 26, 1999; 274(9): 5835 - 5842.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. M. Tebo, H. S. Kim, J. Gao, D. A. Armstrong, and T. A. Hamilton
Interleukin-10 Suppresses IP-10 Gene Transcription by Inhibiting the Production of Class I Interferon
Blood, December 15, 1998; 92(12): 4742 - 4749.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Skov, M. Nielsen, S. Bregenholt, N. Odum, and M. H. Claesson
Activation of Stat-3 Is Involved in the Induction of Apoptosis After Ligation of Major Histocompatibility Complex Class I Molecules on Human Jurkat T Cells
Blood, May 15, 1998; 91(10): 3566 - 3573.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. D. Spencer, F. Di Marco, J. Hooley, S. Pitts-Meek, M. Bauer, A. M. Ryan, B. Sordat, V. C. Gibbs, and M. Aguet
The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor
J. Exp. Med., February 16, 1998; 187(4): 571 - 578.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Yamaoka, T. Otsuka, H. Niiro, Y. Arinobu, Y. Niho, N. Hamasaki, and K. Izuhara
Activation of STAT5 by Lipopolysaccharide Through Granulocyte-Macrophage Colony-Stimulating Factor Production in Human Monocytes
J. Immunol., January 15, 1998; 160(2): 838 - 845.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Bovolenta, S. Gasperini, P. P. McDonald, and M. A. Cassatella
High Affinity Receptor for IgG (Fc{gamma}RI/CD64) Gene and STAT Protein Binding to the IFN-{gamma} Response Region (GRR) Are Regulated Differentially in Human Neutrophils and Monocytes by IL-10
J. Immunol., January 15, 1998; 160(2): 911 - 919.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page