| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 155, Issue 3 1032-1036, Copyright © 1995 by American Association of Immunologists
CUTTING EDGE |
ER Kearney, TL Walunas, RW Karr, PA Morton, DY Loh, JA Bluestone and MK Jenkins
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA.
The importance of CD28 costimulation to a primary T cell response in vivo was assessed in an adoptive transfer system where a small population of peptide-specific CD4+ TCR transgenic T cells can be physically tracked. Ag-dependent clonal expansion of the transgenic T cells in draining lymph nodes was blocked by cyclosporin A and required a CD28 signal that was completely inhibited by CTLA-4-Ig or a combination of anti-B7-1 and anti-B7-2 mAbs, but not by either Ab alone. In vivo treatment with the combination of anti-B7-1 and anti-B7- 2 mAbs also blocked conversion of the Ag-specific T cells to the activated phenotype. In contrast, anti-CTLA-4 Fab greatly enhanced the in vivo clonal expansion of the Ag-specific T cells. These results suggest that Ag-driven proliferation and phenotype conversion of naive CD4+ T cells is dependent on CD28-derived signals and is inhibited by CTLA-4.
This article has been cited by other articles:
|
|
 |
|
  K. L. Edgtton, J. Y. Kausman, M. Li, K. O'Sullivan, C. Lo, P. Hutchinson, H. Yagita, S. R. Holdsworth, and A. R. Kitching Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells J. Am. Soc. Nephrol., March 1, 2008; 19(3): 515 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Singh, M. Cox, and R. H. Schwartz TLR Ligands Differentially Modulate T Cell Responses to Acute and Chronic Antigen Presentation J. Immunol., December 15, 2007; 179(12): 7999 - 8008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Ashour and T. M. Seif The role of B cells in the induction of peripheral T cell tolerance J. Leukoc. Biol., November 1, 2007; 82(5): 1033 - 1039. [Full Text] [PDF]
|
|
|
|
|
|
S. Sengupta, P. Jayaraman, P. M. Chilton, C. R. Casella, and T. C. Mitchell Unrestrained Glycogen Synthase Kinase-3beta Activity Leads to Activated T Cell Death and Can Be Inhibited by Natural Adjuvant J. Immunol., May 15, 2007; 178(10): 6083 - 6091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kocak, K. Lute, X. Chang, K. F. May Jr., K. R. Exten, H. Zhang, S. F. Abdessalam, A. M. Lehman, D. Jarjoura, P. Zheng, et al. Combination Therapy with Anti-CTL Antigen-4 and Anti-4-1BB Antibodies Enhances Cancer Immunity and Reduces Autoimmunity. Cancer Res., July 15, 2006; 66(14): 7276 - 7284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Li, X. Chang, H. Zhang, E. Kocak, C. Ding, P. Zheng, and Y. Liu Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts J. Exp. Med., July 10, 2006; 203(7): 1713 - 1720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, K. K. Dhanireddy, and A. D. Kirk Human Monocytes as Intermediaries between Allogeneic Endothelial Cells and Allospecific T Cells: A Role for Direct Scavenger Receptor-Mediated Endothelial Membrane Uptake in the Initiation of Alloimmunity J. Immunol., January 15, 2006; 176(2): 750 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Homann, W. Dummer, T. Wolfe, E. Rodrigo, A. N. Theofilopoulos, M. B. A. Oldstone, and M. G. von Herrath Lack of Intrinsic CTLA-4 Expression Has Minimal Effect on Regulation of Antiviral T-Cell Immunity J. Virol., January 1, 2006; 80(1): 270 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ji, D. Gondek, and A. A. Hurwitz Provision of Granulocyte-Macrophage Colony-Stimulating Factor Converts an Autoimmune Response to a Self-Antigen into an Antitumor Response J. Immunol., August 1, 2005; 175(3): 1456 - 1463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Stohl, D. Xu, K. S. Kim, C. S. David, and J. P. Allison MHC class II-independent and -dependent T cell expansion and B cell hyperactivity in vivo in mice deficient in CD152 (CTLA-4) Int. Immunol., July 1, 2004; 16(7): 895 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bocek Jr., G. Foucras, and W. E. Paul Interferon {gamma} Enhances Both In Vitro and In Vivo Priming of CD4+ T Cells for IL-4 Production J. Exp. Med., June 21, 2004; 199(12): 1619 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Lemos, L. Fan, D. Lo, and T. M. Laufer CD8{alpha}+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity J. Immunol., November 15, 2003; 171(10): 5077 - 5084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guo, E. Kavanagh, Y. Zang, S. M. Dolan, S. J. Kriynovich, J. A. Mannick, and J. A. Lederer Burn Injury Promotes Antigen-Driven Th2-Type Responses In Vivo J. Immunol., October 15, 2003; 171(8): 3983 - 3990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zheng and M. Monestier Inhibitory Signal Override Increases Susceptibility to Mercury-Induced Autoimmunity J. Immunol., August 1, 2003; 171(3): 1596 - 1601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. K. Walker, L. J. Ausubel, A. Chodos, N. Bekarian, and A. K. Abbas CTLA-4 Differentially Regulates T Cell Responses to Endogenous Tissue Protein Versus Exogenous Immunogen J. Immunol., December 1, 2002; 169(11): 6202 - 6209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. DiPaolo and E. R. Unanue Cutting Edge: The Relative Distribution of T Cells Responding to Chemically Dominant or Minor Epitopes of Lysozyme Is Not Affected by CD40-CD40 Ligand and B7-CD28-CTLA-4 Costimulatory Pathways J. Immunol., September 15, 2002; 169(6): 2832 - 2836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, J. R. Bennink, P. A. Morton, and J. W. Yewdell Mice Deficient in Perforin, CD4+ T Cells, or CD28-Mediated Signaling Maintain the Typical Immunodominance Hierarchies of CD8+ T-Cell Responses to Influenza Virus J. Virol., September 11, 2002; 76(20): 10332 - 10337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Srinivasan, I. E. Gienapp, S. S. Stuckman, C. J. Rogers, S. D. Jewell, P. T. P. Kaumaya, and C. C. Whitacre Suppression of Experimental Autoimmune Encephalomyelitis Using Peptide Mimics of CD28 J. Immunol., August 15, 2002; 169(4): 2180 - 2188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Lang, P. Nguyen, R. Peach, W. C. Gause, and C. S. Via In Vivo CD86 Blockade Inhibits CD4+ T Cell Activation, Whereas CD80 Blockade Potentiates CD8+ T Cell Activation and CTL Effector Function J. Immunol., April 15, 2002; 168(8): 3786 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Suvas, V. Singh, S. Sahdev, H. Vohra, and J. N. Agrewala Distinct Role of CD80 and CD86 in the Regulation of the Activation of B Cell and B Cell Lymphoma J. Biol. Chem., March 1, 2002; 277(10): 7766 - 7775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Nichols, S. K. Bauman, F. B. Schafer, and J. W. Murphy Differences in Components at Delayed-Type Hypersensitivity Reaction Sites in Mice Immunized with Either a Protective or a Nonprotective Immunogen of Cryptococcus neoformans Infect. Immun., February 1, 2002; 70(2): 591 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Evans, R. A. Prell, C. J. Thalhofer, A. A. Hurwitz, and A. D. Weinberg Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of {alpha}OX-40 with {alpha}CTLA-4 J. Immunol., December 15, 2001; 167(12): 6804 - 6811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Iwakoshi, T. G. Markees, N. Turgeon, T. Thornley, A. Cuthbert, J. Leif, N. E. Phillips, J. P. Mordes, D. L. Greiner, and A. A. Rossini4 Skin Allograft Maintenance in a New Synchimeric Model System of Tolerance J. Immunol., December 1, 2001; 167(11): 6623 - 6630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Vanasek, A. Khoruts, T. Zell, and D. L. Mueller Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness J. Immunol., November 15, 2001; 167(10): 5636 - 5644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pulendran, P. Kumar, C. W. Cutler, M. Mohamadzadeh, T. Van Dyke, and J. Banchereau Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo J. Immunol., November 1, 2001; 167(9): 5067 - 5076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Doyle, A. C. Mullen, A. V. Villarino, A. S. Hutchins, F. A. High, H. W. Lee, C. B. Thompson, and S. L. Reiner Induction of Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Restricts Clonal Expansion of Helper T Cells J. Exp. Med., September 24, 2001; 194(7): 893 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hernandez, S. Aung, W. L. Redmond, and L. A. Sherman Phenotypic and Functional Analysis of CD8+ T Cells Undergoing Peripheral Deletion in Response to Cross-Presentation of Self-Antigen J. Exp. Med., September 10, 2001; 194(6): 707 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-B. Wang, F.-D. Shi, H. Li, B. J. Chambers, H. Link, and H.-G. Ljunggren Anti-CTLA-4 Antibody Treatment Triggers Determinant Spreading and Enhances Murine Myasthenia Gravis J. Immunol., May 15, 2001; 166(10): 6430 - 6436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kumar and R. L. Tarleton Antigen-Specific Th1 But Not Th2 Cells Provide Protection from Lethal Trypanosoma cruzi Infection in Mice J. Immunol., April 1, 2001; 166(7): 4596 - 4603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Shi, H. Y. Liu, and C. Nagler-Anderson Enteric Infection Acts as an Adjuvant for the Response to a Model Food Antigen J. Immunol., December 1, 2000; 165(11): 6174 - 6182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pioli, L. Gatta, V. Ubaldi, and G. Doria Inhibition of IgG1 and IgE Production by Stimulation of the B Cell CTLA-4 Receptor J. Immunol., November 15, 2000; 165(10): 5530 - 5536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lühder, C. Chambers, J. P. Allison, C. Benoist, and D. Mathis Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells PNAS, October 12, 2000; (2000) 200348397. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. BUGEON and M. J. DALLMAN Costimulation of T Cells Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): S164 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gramaglia, A. Jember, S. D. Pippig, A. D. Weinberg, N. Killeen, and M. Croft The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion J. Immunol., September 15, 2000; 165(6): 3043 - 3050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, K. Song, S. L. Eck, and Y. Chen An Intra-Peyer's Patch Gene Transfer Model for Studying Mucosal Tolerance: Distinct Roles of B7 and IL-12 in Mucosal T Cell Tolerance J. Immunol., September 15, 2000; 165(6): 3145 - 3153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. McGaha and J. W. Murphy CTLA-4 Down-Regulates the Protective Anticryptococcal Cell-Mediated Immune Response Infect. Immun., August 1, 2000; 68(8): 4624 - 4630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takahashi, T. Tagami, S. Yamazaki, T. Uede, J. Shimizu, N. Sakaguchi, T. W. Mak, and S. Sakaguchi Immunologic Self-Tolerance Maintained by CD25+CD4+ Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte-associated Antigen 4 J. Exp. Med., July 17, 2000; 192(2): 303 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bauman, K. L. Nichols, and J. W. Murphy Dendritic Cells in the Induction of Protective and Nonprotective Anticryptococcal Cell-Mediated Immune Responses J. Immunol., July 1, 2000; 165(1): 158 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Faas, M. A. Giannoni, A. P. Mickle, C. L. Kiesecker, D. J. Reed, D. Wu, W. L. Fodor, J. P. Mueller, L. A. Matis, and R. P. Rother Primary Structure and Functional Characterization of a Soluble, Alternatively Spliced Form of B7-1 J. Immunol., June 15, 2000; 164(12): 6340 - 6348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. KNOTT, P. R. GATER, and C. P. BERTRAND Airway Inflammation Driven by Antigen-specific Resident Lung CD4+ T Cells in alpha beta -T Cell Receptor Transgenic Mice Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1340 - 1348. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kato and H. Nariuchi Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation J. Immunol., April 1, 2000; 164(7): 3554 - 3562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sakurai, J. Ohata, K. Saito, H. Miyajima, T. Hirano, T. Kohsaka, S. Enomoto, K. Okumura, and M. Azuma Blockade of CTLA-4 Signals Inhibits Th2-Mediated Murine Chronic Graft-Versus-Host Disease by an Enhanced Expansion of Regulatory CD8+ T Cells J. Immunol., January 15, 2000; 164(2): 664 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Martin-Fontecha, M. Moro, M. C. Crosti, F. Veglia, G. Casorati, and P. Dellabona Vaccination with Mouse Mammary Adenocarcinoma Cells Coexpressing B7-1 (CD80) and B7-2 (CD86) Discloses the Dominant Effect of B7-1 in the Induction of Antitumor Immunity J. Immunol., January 15, 2000; 164(2): 698 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lefrancois, J. D. Altman, K. Williams, and S. Olson Soluble Antigen and CD40 Triggering Are Sufficient to Induce Primary and Memory Cytotoxic T Cells J. Immunol., January 15, 2000; 164(2): 725 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Iwakoshi, J. P. Mordes, T. G. Markees, N. E. Phillips, A. A. Rossini, and D. L. Greiner Treatment of Allograft Recipients with Donor-Specific Transfusion and Anti-CD154 Antibody Leads to Deletion of Alloreactive CD8+ T Cells and Prolonged Graft Survival in a CTLA4-Dependent Manner J. Immunol., January 1, 2000; 164(1): 512 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-K. Guttormsen, A. H. Sharpe, A. K. Chandraker, A. K. Brigtsen, M. H. Sayegh, and D. L. Kasper Cognate Stimulatory B-Cell-T-Cell Interactions Are Critical for T-Cell Help Recruited by Glycoconjugate Vaccines Infect. Immun., December 1, 1999; 67(12): 6375 - 6384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. P. Heinzel and R. A. Maier Jr. Interleukin-4-Independent Acceleration of Cutaneous Leishmaniasis in Susceptible BALB/c Mice following Treatment with Anti-CTLA4 Antibody Infect. Immun., December 1, 1999; 67(12): 6454 - 6460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Ratts, L. R. Arredondo, P. Bittner, P. J. Perrin, A. E. Lovett-Racke, and M. K. Racke The role of CTLA-4 in tolerance induction and T cell differentiation in experimental autoimmune encephalomyelitis: i.p. antigen administration Int. Immunol., December 1, 1999; 11(12): 1881 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Schweitzer and A. H. Sharpe Mutual Regulation Between B7-1 (CD80) Expressed on T Cells and IL-4 J. Immunol., November 1, 1999; 163(9): 4819 - 4825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Burkhart, G. Y. Liu, S. M. Anderton, B. Metzler, and D. C. Wraith Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10 Int. Immunol., October 1, 1999; 11(10): 1625 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kirman, K. McCoy, S. Hook, M. Prout, B. Delahunt, I. Orme, A. Frank, and G. Le Gros CTLA-4 Blockade Enhances the Immune Response Induced by Mycobacterial Infection but Does Not Lead to Increased Protection Infect. Immun., August 1, 1999; 67(8): 3786 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Rogers and M. Croft Peptide Dose, Affinity, and Time of Differentiation Can Contribute to the Th1/Th2 Cytokine Balance J. Immunol., August 1, 1999; 163(3): 1205 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. Chai, S. Vendetti, I. Bartok, D. Schoendorf, K. Takacs, J. Elliott, R. Lechler, and J. Dyson Critical Role of Costimulation in the Activation of Naive Antigen-Specific TCR Transgenic CD8+ T Cells In Vitro J. Immunol., August 1, 1999; 163(3): 1298 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Perrin, C. H. June, J. H. Maldonado, R. B. Ratts, and M. K. Racke Blockade of CD28 During In Vitro Activation of Encephalitogenic T Cells or After Disease Onset Ameliorates Experimental Autoimmune Encephalomyelitis J. Immunol., August 1, 1999; 163(3): 1704 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Riley, K. Schlienger, P. J. Blair, B. Carreno, N. Craighead, D. Kim, R. G. Carroll, and C. H. June Modulation of Susceptibility to HIV-1 Infection by the Cytotoxic T Lymphocyte Antigen 4 Costimulatory Molecule J. Exp. Med., June 6, 1999; 191(11): 1987 - 1998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Blazar, P. A. Taylor, A. Panoskaltsis-Mortari, A. H. Sharpe, and D. A. Vallera Opposing Roles of CD28:B7 and CTLA-4:B7 Pathways in Regulating In Vivo Alloresponses in Murine Recipients of MHC Disparate T Cells J. Immunol., June 1, 1999; 162(11): 6368 - 6377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-C. Lee, Z. H. Jaffar, K.-S. Wan, S. T. Holgate, and K. Roberts Regulation of Pulmonary T Cell Responses to Inhaled Antigen: Role in Th1- and Th2-Mediated Inflammation J. Immunol., June 1, 1999; 162(11): 6867 - 6879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Khattri, J. A. Auger, M. D. Griffin, A. H. Sharpe, and J. A. Bluestone Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses J. Immunol., May 15, 1999; 162(10): 5784 - 5791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Brunner, C. A. Chambers, F. K.-M. Chan, J. Hanke, A. Winoto, and J. P. Allison CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation J. Immunol., May 15, 1999; 162(10): 5813 - 5820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Metzler, C. Burkhart, and D. C. Wraith Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo Int. Immunol., May 1, 1999; 11(5): 667 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gudmundsdottir, A. D. Wells, and L. A. Turka Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity J. Immunol., May 1, 1999; 162(9): 5212 - 5223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. McCoy, I. F. Hermans, J. Henry Fras |
