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The Journal of Immunology, Vol 155, Issue 3 1028-1031, Copyright © 1995 by American Association of Immunologists
CUTTING EDGE |
LL Carter and RW Dutton
Department of Molecular Pathology, University of California San Diego Cancer Center, La Jolla 92093, USA.
IFN-gamma-secreting T1 and IL-5-secreting T2 subsets of CD8 effectors were generated in vitro using freshly isolated cells from wild-type and perforin knockout mice stimulated with allogeneic Ag-presenting cells. Both T1 and T2 effectors from wild-type mice exhibited perforin- mediated cytolysis. T1, but not T2, populations from perforin knockout mice displayed significant lysis by the Fas-mediated pathway. Th1 cells have recently been shown to be regulated by Fas and we speculate that Fas-mediated mechanisms are involved in the regulation of both Th1 and T1 populations of T cells.
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