The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leelayuwat, C.
Right arrow Articles by Dawkins, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leelayuwat, C.
Right arrow Articles by Dawkins, R. L.

The Journal of Immunology, Vol 155, Issue 2 692-698, Copyright © 1995 by American Association of Immunologists

ARTICLES

Clustering of diverse replicated sequences in the MHC. Evidence for en bloc duplication

C Leelayuwat, M Pinelli and RL Dawkins
Centre for Molecular Immunology and Instrumentation, University of Western Australia, Perth.

The MHC contains clusters of polymorphic duplicated genes and gene sequences. It has been thought that these duplicated genes and sequences have arisen from single gene duplications. We compared the cloned region between TNF and HLA-B with the region in close proximity to HLA-A using sequence analysis and DNA hybridization. The results indicate that several sequences existing in the region centromeric of HLA-B are also present in close proximity to HLA-A. These include sequences belonging to the P5, BAT1, and PERB11 gene families as well as HLA class I gene sequences. Interestingly, when the two regions of approximately 200 kilobases are compared, the replicated sequences are organized similarly but in an inverted fashion suggesting the existence of an historical inverted en bloc duplication. Thus, we propose that the origin of these MHC gene clusters involves several mechanisms. In addition to single gene replication, a long-range duplication of a genomic block must have occurred. It is possible that a block at the telomeric end of the MHC represents a basic functional genomic unit conserved and duplicated en bloc.


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
J. K Kulski, T. Anzai, T. Shiina, and H. Inoko
Rhesus Macaque Class I Duplicon Structures, Organization, and Evolution Within the Alpha Block of the Major Histocompatibility Complex
Mol. Biol. Evol., November 1, 2004; 21(11): 2079 - 2091.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Amadou, R. M. Younger, S. Sims, L. H. Matthews, J. Rogers, A. Kumanovics, A. Ziegler, S. Beck, and K. Fischer Lindahl
Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex
Hum. Mol. Genet., November 15, 2003; 12(22): 3025 - 3040.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
S. Gaudieri, J. K. Kulski, R. L. Dawkins, and T. Gojobori
Different Evolutionary Histories in Two Subgenomic Regions of the Major Histocompatibility Complex
Genome Res., June 1, 1999; 9(6): 541 - 549.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.