| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 155, Issue 11 5382-5390, Copyright © 1995 by American Association of Immunologists
ARTICLES |
KM Skubitz, KD Campbell, K Ahmed and AP Skubitz
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.
The granulocyte activation Ags, CD66a, CD66b, CD66c, and CD66d, are expressed at low levels on resting blood granulocytes, but their surface expression is up-regulated following stimulation. CD66a, in contrast to CD66b and CD66c which are anchored to the membrane via a glycosyl-phosphatidylinositol linkage, is a transmembrane protein with a cytoplasmic domain. We have previously reported that CD66a is phosphorylated in human neutrophils, largely on tyrosine, with a lower level of phosphoserine. We have now found that CD66a undergoes a rapid increase in phosphorylation following stimulation with FMLP, platelet- activating factor, and 12-O-tetradecanoyl-phorbol-13-acetate. This increase in phosphorylation was transient, with maximal phosphorylation observed by 1 min and a return to base line by 5 min following stimulation. Protein kinase activity was detected in neutrophils associated with CD66a, CD66b, and CD66c. Most of the protein kinase activity associated with these Ags was tyrosine kinase activity, with a lesser amount of threonine and serine kinase activities. Lyn and Hck accounted for much of the associated tyrosine kinase activity. The data suggest that phosphorylation of CD66a on tyrosine by an associated tyrosine kinase may play a role in the function of CD66a. In addition, associated tyrosine kinase activity may play a role in signal transduction from CD66a, CD66b, and CD66c to regulate other cell functions.
This article has been cited by other articles:
|
|
 |
|
  L. Jin, Y. Li, C.-J. Chen, M. A. Sherman, K. Le, and J. E. Shively Direct Interaction of Tumor Suppressor CEACAM1 with Beta Catenin: Identification of Key Residues in the Long Cytoplasmic Domain Experimental Biology and Medicine, July 1, 2008; 233(7): 849 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Chen, L. Chen, S.-W. Qiao, T. Nagaishi, and R. S. Blumberg Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Inhibits Proximal TCR Signaling by Targeting ZAP-70 J. Immunol., May 1, 2008; 180(9): 6085 - 6093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Klaile, M. M. Muller, C. Kannicht, W. Otto, B. B. Singer, W. Reutter, B. Obrink, and L. Lucka The Cell Adhesion Receptor Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 Regulates Nucleocytoplasmic Trafficking of DNA Polymerase {delta}-Interacting Protein 38 J. Biol. Chem., September 7, 2007; 282(36): 26629 - 26640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Schmitter, S. Pils, S. Weibel, F. Agerer, L. Peterson, A. Buntru, K. Kopp, and C. R. Hauck Opa Proteins of Pathogenic Neisseriae Initiate Src Kinase-Dependent or Lipid Raft-Mediated Uptake via Distinct Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule Isoforms Infect. Immun., August 1, 2007; 75(8): 4116 - 4126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. SHAO, M. ALLEZ, M.-S. PARK, and L. MAYER Immunomodulatory roles of the carcinoembryonic antigen family of glycoproteins. Ann. N.Y. Acad. Sci., August 1, 2006; 1072: 194 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Bamberger, V. Minas, S. N. Kalantaridou, J. Radde, H. Sadeghian, T. Loning, I. Charalampopoulos, J. Brummer, C. Wagener, C. M. Bamberger, et al. Corticotropin-Releasing Hormone Modulates Human Trophoblast Invasion through Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulation Am. J. Pathol., January 1, 2006; 168(1): 141 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Klaile, M. M. Muller, C. Kannicht, B. B. Singer, and L. Lucka CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration J. Cell Sci., December 1, 2005; 118(23): 5513 - 5524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Muller, B. B. Singer, E. Klaile, B. Obrink, and L. Lucka Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells Blood, May 15, 2005; 105(10): 3925 - 3934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Servin Pathogenesis of Afa/Dr Diffusely Adhering Escherichia coli Clin. Microbiol. Rev., April 1, 2005; 18(2): 264 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Edwards and M. A. Apicella The Molecular Mechanisms Used by Neisseria gonorrhoeae To Initiate Infection Differ between Men and Women Clin. Microbiol. Rev., October 1, 2004; 17(4): 965 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Duxbury, H. Ito, E. Benoit, T. Waseem, S. W. Ashley, and E. E. Whang A Novel Role for Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 as a Determinant of Gemcitabine Chemoresistance in Pancreatic Adenocarcinoma Cells Cancer Res., June 1, 2004; 64(11): 3987 - 3993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Duxbury, H. Ito, S. W. Ashley, and E. E. Whang CEACAM6 Cross-linking Induces Caveolin-1-dependent, Src-mediated Focal Adhesion Kinase Phosphorylation in BxPC3 Pancreatic Adenocarcinoma Cells J. Biol. Chem., May 28, 2004; 279(22): 23176 - 23182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kirshner, D. Schumann, and J. E. Shively CEACAM1, a Cell-Cell Adhesion Molecule, Directly Associates with Annexin II in a Three-dimensional Model of Mammary Morphogenesis J. Biol. Chem., December 12, 2003; 278(50): 50338 - 50345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Greicius, E. Severinson, N. Beauchemin, B. Obrink, and B. B. Singer CEACAM1 is a potent regulator of B cell receptor complex-induced activation J. Leukoc. Biol., July 1, 2003; 74(1): 126 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Houde, S. Roy, N. Leung, D. W. Nicholson, and N. Beauchemin The Cell Adhesion Molecule CEACAM1-L Is a Substrate of Caspase-3-mediated Cleavage in Apoptotic Mouse Intestinal Cells J. Biol. Chem., May 2, 2003; 278(19): 16929 - 16935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Sundberg and B. Obrink CEACAM1 isoforms with different cytoplasmic domains show different localization, organization and adhesive properties in polarized epithelial cells J. Cell Sci., March 15, 2002; 115(6): 1273 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Brummer, A. Ebrahimnejad, R. Flayeh, U. Schumacher, T. Loning, A.-M. Bamberger, and C. Wagener cis Interaction of the Cell Adhesion Molecule CEACAM1 with Integrin {beta}3 Am. J. Pathol., August 1, 2001; 159(2): 537 - 546. [Abstract] [Full Text]
|
|
|
|
|
|
R. Kammerer, D. Stober, B. B. Singer, B. Obrink, and J. Reimann Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation J. Immunol., June 1, 2001; 166(11): 6537 - 6544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.A Costa, L.E.A de Wit, V de Valk, P Serrano, A.J Wardeh, P.W Serruys, and W Sluiter Indirect evidence for a role of a subpopulation of activated neutrophils in the remodelling process after percutaneous coronary intervention Eur. Heart J., April 1, 2001; 22(7): 580 - 586. [Abstract] [PDF]
|
|
|
|
|
|
L. Ottonello, A. L. Epstein, M. Mancini, M. Amelotti, P. Dapino, and F. Dallegri Monoclonal Lym-1 antibody-targeted lysis of B lymphoma cells by neutrophils. Evidence for two mechanisms of Fc{gamma}RII-dependent cytolysis J. Leukoc. Biol., November 1, 2000; 68(5): 662 - 668. [Abstract] [Full Text]
|
|
|
|
|
|
J. Guignot, I. Peiffer, M.-F. Bernet-Camard, D. M. Lublin, C. Carnoy, S. L. Moseley, and A. L. Servin Recruitment of CD55 and CD66e Brush Border-Associated Glycosylphosphatidylinositol-Anchored Proteins by Members of the Afa/Dr Diffusely Adhering Family of Escherichia coli That Infect the Human Polarized Intestinal Caco-2/TC7 Cells Infect. Immun., June 1, 2000; 68(6): 3554 - 3563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Skubitz, K. D. Campbell, and A. P. N. Skubitz Synthetic Peptides of CD66a Stimulate Neutrophil Adhesion to Endothelial Cells J. Immunol., April 15, 2000; 164(8): 4257 - 4264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Singer, I. Scheffrahn, and B. Öbrink The Tumor Growth-inhibiting Cell Adhesion Molecule CEACAM1 (C-CAM) Is Differently Expressed in Proliferating and Quiescent Epithelial Cells and Regulates Cell Proliferation Cancer Res., March 1, 2000; 60(5): 1236 - 1244. [Abstract] [Full Text]
|
|
|
|
|
|
S. Scholzel, W. Zimmermann, G. Schwarzkopf, F. Grunert, B. Rogaczewski, and J. Thompson Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas Am. J. Pathol., February 1, 2000; 156(2): 595 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Feuk-Lagerstedt, E. T. Jordan, H. Leffler, C. Dahlgren, and A. Karlsson Identification of CD66a and CD66b as the Major Galectin-3 Receptor Candidates in Human Neutrophils J. Immunol., November 15, 1999; 163(10): 5592 - 5598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Hauck, E. Gulbins, F. Lang, and T. F. Meyer Tyrosine Phosphatase SHP-1 Is Involved in CD66-Mediated Phagocytosis of Opa52-Expressing Neisseria gonorrhoeae Infect. Immun., October 1, 1999; 67(10): 5490 - 5494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ilangumaran, S. Arni, G. van Echten-Deckert, B. Borisch, and D. C. Hoessli Microdomain-dependent Regulation of Lck and Fyn Protein-Tyrosine Kinases in T Lymphocyte Plasma Membranes Mol. Biol. Cell, April 1, 1999; 10(4): 891 - 905. [Abstract] [Full Text]
|
|
|
|
|
|
M. Huber, L. Izzi, P. Grondin, C. Houde, T. Kunath, A. Veillette, and N. Beauchemin The Carboxyl-terminal Region of Biliary Glycoprotein Controls Its Tyrosine Phosphorylation and Association with Protein-tyrosine Phosphatases SHP-1 and SHP-2 in Epithelial Cells J. Biol. Chem., January 1, 1999; 274(1): 335 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hauses, R. R. Tonjes, and M. Grez The Transcription Factor Sp1 Regulates the Myeloid-specific Expression of the Human Hematopoietic Cell Kinase (HCK) Gene through Binding to Two Adjacent GC Boxes within the HCK Promoter-Proximal Region J. Biol. Chem., November 27, 1998; 273(48): 31844 - 31852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. T. Estrera, D.-T. Chen, W. Luo, D. C. Hixson, and S.-H. Lin Signal Transduction by the CEACAM1 Tumor Suppressor. PHOSPHORYLATION OF SERINE 503 IS REQUIRED FOR GROWTH-INHIBITORY ACTIVITY J. Biol. Chem., April 27, 2001; 276(18): 15547 - 15553. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
