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The Journal of Immunology, Vol 155, Issue 11 5352-5358, Copyright © 1995 by American Association of Immunologists

ARTICLES

Molecular cloning and functional characterization of a novel member of the C-C chemokine family

T Hara, KB Bacon, LC Cho, A Yoshimura, Y Morikawa, NG Copeland, DJ Gilbert, NA Jenkins, TJ Schall and A Miyajima
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto 94304, USA.

Chemokines play an important role in immune and inflammatory responses by inducing migration and adhesion of leukocytes. We have isolated a novel chemokine cDNA, designated CCF18, from a cDNA library of an IL-3- dependent murine pro-B cell line, Ba/F3. The cDNA encodes a protein structurally related to the C-C chemokine members. Among this family, C10 shows the highest homology to CCF18, and MIP-1 alpha also has a significant homology but to a lesser extent. CCF18 produced from COS cells induced chemotaxis and Ca2+ flux in CD4+ T cell clones. Moreover, prior administration of MIP-1 alpha desensitized the cells to CCF18. The CCF18 gene (Scya10) was mapped to a middle region of murine chromosome 11, where other genes for several C-C chemokine members are localized. These results clearly indicate that CCF18 is a new member of the C-C chemokine family. Since a high level of CCF18 mRNA is constitutively expressed in macrophage and myeloid cell lines, CCF18 may play a role in inflammatory processes.


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