| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 155, Issue 10 4588-4595, Copyright © 1995 by American Association of Immunologists
ARTICLES |
S Hess, A Rensing-Ehl, R Schwabe, P Bufler and H Engelmann
Institute for Immunology, University of Munich, Germany.
CD40 is a member of the TNF receptor family that was first characterized as an important T-B cell interaction molecule. This receptor is also expressed on many other cell types, including normal basal epithelium, carcinomas, and transformed cell lines. The functions of CD40 in non-B cells are largely unknown. Our studies demonstrate that CD40 mediates nuclear factor kappa B (NF-kappa B) mobilization and IL-6 production in nonhematopoietic cells. Stimulation of the transformed fibroblast cell line SV80 with CD40 ligand (CD40L) or anti- CD40 Ab resulted in the production of IL-6; this could be increased by IFN-gamma pretreatment, which is known to up-regulate CD40 expression. Studies with transfectants overexpressing CD40 demonstrated that activation of CD40 alone is sufficient to induce IL-6 production. The transcription factor NF-kappa B appears to play a central role in CD40- mediated activation of the IL-6 gene; NF-kappa B mobilization directly preceded CD40-mediated IL-6 production, and suppression of NF-kappa B mobilization with the metabolic inhibitor D609 also suppressed the IL-6 response. A striking similarity to the requirements for TNF-induced IL- 6 production, which is mediated by the p55TNF receptor in SV80 cells, was observed. In view of the intracellular homologies between CD40 and the p55TNF receptor, it should be considered that the two receptors share common components in their signaling pathways that lead to IL-6 production.
This article has been cited by other articles:
|
|
 |
|
  R. K. Thomas, M. L. Sos, T. Zander, O. Mani, A. Popov, D. Berenbrinker, S. Smola-Hess, J. L. Schultze, and J. Wolf Inhibition of Nuclear Translocation of Nuclear Factor-{kappa}B Despite Lack of Functional I{kappa}B{alpha} Protein Overcomes Multiple Defects in Apoptosis Signaling in Human B-Cell Malignancies Clin. Cancer Res., November 15, 2005; 11(22): 8186 - 8194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Baccam, S.-Y. Woo, C. Vinson, and G. A. Bishop CD40-Mediated Transcriptional Regulation of the IL-6 Gene in B Lymphocytes: Involvement of NF-{kappa}B, AP-1, and C/EBP J. Immunol., March 15, 2003; 170(6): 3099 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. W. Schrum, I. Marriott, B. R. Butler, E. K. Thomas, M. C. Hudson, and K. L. Bost Functional CD40 Expression Induced following Bacterial Infection of Mouse and Human Osteoblasts Infect. Immun., March 1, 2003; 71(3): 1209 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kiriakidis, E. Andreakos, C. Monaco, B. Foxwell, M. Feldmann, and E. Paleolog VEGF expression in human macrophages is NF-{kappa}B-dependent: studies using adenoviruses expressing the endogenous NF-{kappa}B inhibitor I{kappa}B{alpha} and a kinase-defective form of the I{kappa}B kinase 2 J. Cell Sci., February 15, 2003; 116(4): 665 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Abe, Y. Shintani, Y. Eto, K. Harada, M. Kosaka, and T. Matsumoto Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells J. Leukoc. Biol., August 1, 2002; 72(2): 347 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Atamas, I. G. Luzina, H. Dai, S. G. Wilt, and B. White Synergy Between CD40 Ligation and IL-4 on Fibroblast Proliferation Involves IL-4 Receptor Signaling J. Immunol., February 1, 2002; 168(3): 1139 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ghia, P. Transidico, J. P. Veiga, C. Schaniel, F. Sallusto, K. Matsushima, S. E. Sallan, A. G. Rolink, A. Mantovani, L. M. Nadler, et al. Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells Blood, August 1, 2001; 98(3): 533 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kaufman, B. A. Graf, E. C. Leung, S. J. Pollock, L. Koumas, S. Y. Reddy, T. M. Blieden, T. J. Smith, and R. P. Phipps Fibroblasts as Sentinel Cells : Role of the CD40-CD40 Ligand System in Fibroblast Activation and Lung Inflammation and Fibrosis Chest, July 1, 2001; 120(2007): 53S - 55S. [Full Text] [PDF]
|
|
|
|
|
|
R. F. Schwabe, B. Schnabl, Y. O. Kweon, and D. A. Brenner CD40 Activates NF-{{kappa}}B and c-Jun N-Terminal Kinase and Enhances Chemokine Secretion on Activated Human Hepatic Stellate Cells J. Immunol., June 1, 2001; 166(11): 6812 - 6819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. WOLTMAN, S. DE HAIJ, J. G. BOONSTRA, S. J.P. GOBIN, M. R. DAHA, and C. V. KOOTEN Interleukin-17 and CD40-Ligand Synergistically Enhance Cytokine and Chemokine Production by Renal Epithelial Cells J. Am. Soc. Nephrol., November 1, 2000; 11(11): 2044 - 2055. [Abstract] [Full Text]
|
|
|
|
|
|
S. Hess, H. Smola, U. Sandaradura de Silva, D. Hadaschik, D. Kube, S. E. Baldus, U. Flucke, and H. Pfister Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production J. Immunol., August 15, 2000; 165(4): 1939 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Solanilla, J. Dechanet, A. El Andaloussi, M. Dupouy, F. Godard, J. Chabrol, P. Charbord, J. Reiffers, A. T. Nurden, B. Weksler, et al. CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells Blood, June 15, 2000; 95(12): 3758 - 3764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-M. Park, H.-S. Kim, J. Choe, and T. H. Lee Differential Induction of Cytokine Genes and Activation of Mitogen-Activated Protein Kinase Family by Soluble CD40 Ligand and TNF in a Human Follicular Dendritic Cell Line J. Immunol., July 15, 1999; 163(2): 631 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Sedger, D. M. Shows, R. A. Blanton, J. J. Peschon, R. G. Goodwin, D. Cosman, and S. R. Wiley IFN-{gamma} Mediates a Novel Antiviral Activity Through Dynamic Modulation of TRAIL and TRAIL Receptor Expression J. Immunol., July 15, 1999; 163(2): 920 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Altenburg, S. E. Baldus, H. Smola, H. Pfister, and S. Hess CD40 Ligand-CD40 Interaction Induces Chemokines in Cervical Carcinoma Cells in Synergism with IFN-{gamma} J. Immunol., April 1, 1999; 162(7): 4140 - 4147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. V. Henriquez, E. Floettmann, M. Salmon, M. Rowe, and A. B. Rickinson Differential Responses to CD40 Ligation Among Burkitt Lymphoma Lines That Are Uniformly Responsive to Epstein-Barr Virus Latent Membrane Protein 1 J. Immunol., March 15, 1999; 162(6): 3298 - 3307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. v. Leoprechting, P. van der Bruggen, H. L. Pahl, A. Aruffo, and J. C. Simon Stimulation of CD40 on Immunogenic Human Malignant Melanomas Augments Their Cytotoxic T Lymphocyte-mediated Lysis and Induces Apoptosis Cancer Res., March 1, 1999; 59(6): 1287 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Busch and G. A. Bishop The EBV Transforming Protein, Latent Membrane Protein 1, Mimics and Cooperates with CD40 Signaling in B Lymphocytes J. Immunol., March 1, 1999; 162(5): 2555 - 2561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gupta, D. Xia, M. Jiang, S. Lee, and A. B. Pernis Signaling Pathways Mediated by the TNF- and Cytokine-Receptor Families Target a Common cis-Element of the IFN Regulatory Factor 1 Promoter J. Immunol., December 1, 1998; 161(11): 5997 - 6004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Jeppson, H. R. Patel, N. Sakata, J. Domenico, N. Terada, and E. W. Gelfand Requirement for Dual Signals by Anti-CD40 and IL-4 for the Induction of Nuclear Factor-{kappa}B, IL-6, and IgE in Human B Lymphocytes J. Immunol., August 15, 1998; 161(4): 1738 - 1742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Sempowski, J. Rozenblit, T. J. Smith, and R. P. Phipps Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production Am J Physiol Cell Physiol, March 1, 1998; 274(3): C707 - C714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Smith, G. D. Sempowski, C. S. Berenson, H. J. Cao, H.-S. Wang, and R. P. Phipps Human Thyroid Fibroblasts Exhibit a Distinctive Phenotype in Culture: Characteristic Ganglioside Profile and Functional CD40 Expression Endocrinology, December 1, 1997; 138(12): 5576 - 5588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mackay, G. R. Majeau, P. S. Hochman, and J. L. Browning Lymphotoxin beta Receptor Triggering Induces Activation of the Nuclear Factor kappa B Transcription Factor in Some Cell Types J. Biol. Chem., October 4, 1996; 271(40): 24934 - 24938. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
