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The Journal of Immunology, Vol 155, Issue 10 4529-4533, Copyright © 1995 by American Association of Immunologists

CUTTING EDGE

Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases

VP Poltoratsky, X Shi, JD York, MR Lieber and TH Carter
Department of Biological Sciences, St. John's University, Jamaica, NY 11439, USA.

DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA- PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.


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