The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brezinschek, H. P.
Right arrow Articles by Lipsky, P. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brezinschek, H. P.
Right arrow Articles by Lipsky, P. E.

The Journal of Immunology, Vol 155, Issue 1 190-202, Copyright © 1995 by American Association of Immunologists

ARTICLES

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction

HP Brezinschek, RI Brezinschek and PE Lipsky
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235, USA.

The VH gene repertoire of human peripheral B cells was analyzed using PCR analysis of individual blood B cells. Because genomic DNA of single B cells was analyzed, data from both productive and nonproductive VDJ rearrangements were obtained. Nine out of 75 B cells contained both functional and nonfunctional rearrangement products, whereas 62/75 had a single productive VDJ rearrangement. The distribution of VH families was ordered in accordance with the germline complexity, although a bias toward VH3 and some of its members was found. This bias was noted in both the productively and nonproductively rearranged repertoires, indicating that it resulted from molecular and not selective processes. Evidence for negative selection of certain VH3 and VH4 family members was noted in that they were found less often as productive than nonproductive VDJ rearrangements. In addition, evidence for positive selection based on CDR3 was obtained, in that JH6 and DXP'1 were found at a higher frequency in the productively compared with the nonproductively rearranged repertoire. The CDR3 segments were markedly heterogenous, with a much greater degree of variability noted in the nonproductive VDJ rearrangements. Finally, a much greater frequency of mutations was noted in the nonproductively rearranged VH genes within individual B cells. These results have begun to delineate the human peripheral B cell repertoire and identify processes that shape it both positively and negatively.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
N. S. Longo, C. L. Satorius, A. Plebani, A. Durandy, and P. E. Lipsky
Characterization of Ig Gene Somatic Hypermutation in the Absence of Activation-Induced Cytidine Deaminase
J. Immunol., July 15, 2008; 181(2): 1299 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
U. Hershberg, M. Uduman, M. J. Shlomchik, and S. H. Kleinstein
Improved methods for detecting selection by mutation analysis of Ig V region sequences
Int. Immunol., May 1, 2008; 20(5): 683 - 694.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. P. Owens, K. M. Winges, A. M. Ritchie, S. Edwards, M. P. Burgoon, L. Lehnhoff, K. Nielsen, J. Corboy, D. H. Gilden, and J. L. Bennett
VH4 Gene Segments Dominate the Intrathecal Humoral Immune Response in Multiple Sclerosis
J. Immunol., November 1, 2007; 179(9): 6343 - 6351.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Gonzalez, M. van der Burg, R. Garcia-Sanz, J. A. Fenton, A. W. Langerak, M. Gonzalez, J. J. M. van Dongen, J. F. San Miguel, and G. J. Morgan
Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma
Blood, November 1, 2007; 110(9): 3112 - 3121.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. V. Williams, Z. Chen, G. Cseke, D. W. Wright, C. J. Keefer, S. J. Tollefson, A. Hessell, A. Podsiad, B. E. Shepherd, P. P. Sanna, et al.
A Recombinant Human Monoclonal Antibody to Human Metapneumovirus Fusion Protein That Neutralizes Virus In Vitro and Is Effective Therapeutically In Vivo
J. Virol., August 1, 2007; 81(15): 8315 - 8324.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Qian, L. A. Diaz, J. Ye, and S. H. Clarke
Dissecting the Anti-Desmoglein Autoreactive B Cell Repertoire in Pemphigus Vulgaris Patients
J. Immunol., May 1, 2007; 178(9): 5982 - 5990.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. D. Volkheimer, J. B. Weinberg, B. E. Beasley, J. F. Whitesides, J. P. Gockerman, J. O. Moore, G. Kelsoe, B. K. Goodman, and M. C. Levesque
Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification
Blood, February 15, 2007; 109(4): 1559 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Zemlin, G. Hoersch, C. Zemlin, A. Pohl-Schickinger, M. Hummel, C. Berek, R. F. Maier, and K. Bauer
The Postnatal Maturation of the Immunoglobulin Heavy Chain IgG Repertoire in Human Preterm Neonates Is Slower than in Term Neonates
J. Immunol., January 15, 2007; 178(2): 1180 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. C. Watson, C. S. Moffatt-Blue, R. Z. McDonald, E. Kompfner, D. Ait-Azzouzene, D. Nemazee, A. N. Theofilopoulos, D. H. Kono, and A. J. Feeney
Paucity of V-D-D-J Rearrangements and VH Replacement Events in Lupus Prone and Nonautoimmune TdT-/- and TdT+/+ Mice
J. Immunol., July 15, 2006; 177(2): 1120 - 1128.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J Voswinkel, A Mueller, J A Kraemer, P Lamprecht, K Herlyn, K Holl-Ulrich, A C Feller, S Pitann, A Gause, and W L Gross
B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions
Ann Rheum Dis, July 1, 2006; 65(7): 859 - 864.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
S. Nakamura-Kikuoka, K. Takahi, H. Tsuboi, T. Toyosaki-Maeda, M. Maeda-Tanimura, C. Wakasa, N. Kikuchi, S. Norioka, M. Iwasaki, T. Matsutani, et al.
Limited VH gene usage in B-cell clones established with nurse-like cells from patients with rheumatoid arthritis
Rheumatology, May 1, 2006; 45(5): 549 - 557.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Babbage, C. H. Ottensmeier, J. Blaydes, F. K. Stevenson, and S. S. Sahota
Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines.
Cancer Res., April 15, 2006; 66(8): 3996 - 4000.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Enders, P. Fisch, K. Schwarz, U. Duffner, U. Pannicke, E. Nikolopoulos, A. Peters, M. Orlowska-Volk, D. Schindler, W. Friedrich, et al.
A Severe Form of Human Combined Immunodeficiency Due to Mutations in DNA Ligase IV.
J. Immunol., April 15, 2006; 176(8): 5060 - 5068.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Viau, N. S. Longo, P. E. Lipsky, and M. Zouali
Staphylococcal Protein A Deletes B-1a and Marginal Zone B Lymphocytes Expressing Human Immunoglobulins: An Immune Evasion Mechanism
J. Immunol., December 1, 2005; 175(11): 7719 - 7727.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Kolibab, S. L. Smithson, B. Rabquer, S. Khuder, and M. A. J. Westerink
Immune Response to Pneumococcal Polysaccharides 4 and 14 in Elderly and Young Adults: Analysis of the Variable Heavy Chain Repertoire
Infect. Immun., November 1, 2005; 73(11): 7465 - 7476.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. E. Coupland, M. Hummel, H.-H. Muller, and H. Stein
Molecular Analysis of Immunoglobulin Genes in Primary Intraocular Lymphoma
Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3507 - 3514.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. P. Sims, R. Ettinger, Y. Shirota, C. H. Yarboro, G. G. Illei, and P. E. Lipsky
Identification and characterization of circulating human transitional B cells
Blood, June 1, 2005; 105(11): 4390 - 4398.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
N.-Y. Zheng, K. Wilson, M. Jared, and P. C. Wilson
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation
J. Exp. Med., May 2, 2005; 201(9): 1467 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-H. Weitkamp, N. L. Kallewaard, A. L. Bowen, B. J. LaFleur, H. B. Greenberg, and J. E. Crowe Jr
VH1-46 Is the Dominant Immunoglobulin Heavy Chain Gene Segment in Rotavirus-Specific Memory B Cells Expressing the Intestinal Homing Receptor {alpha}4{beta}7
J. Immunol., March 15, 2005; 174(6): 3454 - 3460.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Ghosh, A. C. Steere, B. D. Stollar, and B. T. Huber
In Situ Diversification of the Antibody Repertoire in Chronic Lyme Arthritis Synovium
J. Immunol., March 1, 2005; 174(5): 2860 - 2869.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. F. Widhopf II, L. Z. Rassenti, T. L. Toy, J. G. Gribben, W. G. Wierda, and T. J. Kipps
Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
Blood, October 15, 2004; 104(8): 2499 - 2504.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. M. Ritchie, D. H. Gilden, R. A. Williamson, M. P. Burgoon, X. Yu, K. Helm, J. R. Corboy, and G. P. Owens
Comparative Analysis of the CD19+ and CD138+ Cell Antibody Repertoires in the Cerebrospinal Fluid of Patients with Multiple Sclerosis
J. Immunol., July 1, 2004; 173(1): 649 - 656.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Viau, N. S. Longo, P. E. Lipsky, L. Bjorck, and M. Zouali
Specific In Vivo Deletion of B-Cell Subpopulations Expressing Human Immunoglobulins by the B-Cell Superantigen Protein L
Infect. Immun., June 1, 2004; 72(6): 3515 - 3523.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. M. Souto-Carneiro, N. S. Longo, D. E. Russ, H.-w. Sun, and P. E. Lipsky
Characterization of the Human Ig Heavy Chain Antigen Binding Complementarity Determining Region 3 Using a Newly Developed Software Algorithm, JOINSOLVER
J. Immunol., June 1, 2004; 172(11): 6790 - 6802.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Magrangeas, M.-L. Cormier, G. Descamps, N. Gouy, L. Lode, M.-P. Mellerin, J.-L. Harousseau, R. Bataille, S. Minvielle, and H. Avet-Loiseau
Light-chain only multiple myeloma is due to the absence of functional (productive) rearrangement of the IgH gene at the DNA level
Blood, May 15, 2004; 103(10): 3869 - 3875.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. T. Messmer, E. Albesiano, D. Messmer, and N. Chiorazzi
The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process
Blood, May 1, 2004; 103(9): 3490 - 3495.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. F. Lausen, L. Hougs, L. Schejbel, C. Heilmann, and T. Barington
Human Memory B Cells Transferred by Allogenic Bone Marrow Transplantation Contribute Significantly to the Antibody Repertoire of the Recipient
J. Immunol., March 1, 2004; 172(5): 3305 - 3318.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. A. Coker, S. R. Durham, and H. J. Gould
Local Somatic Hypermutation and Class Switch Recombination in the Nasal Mucosa of Allergic Rhinitis Patients
J. Immunol., November 15, 2003; 171(10): 5602 - 5610.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-H. Weitkamp, N. Kallewaard, K. Kusuhara, E. Bures, J. V. Williams, B. LaFleur, H. B. Greenberg, and J. E. Crowe Jr.
Infant and Adult Human B Cell Responses to Rotavirus Share Common Immunodominant Variable Gene Repertoires
J. Immunol., November 1, 2003; 171(9): 4680 - 4688.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. P. Owens, A. M. Ritchie, M. P. Burgoon, R. A. Williamson, J. R. Corboy, and D. H. Gilden
Single-Cell Repertoire Analysis Demonstrates that Clonal Expansion Is a Prominent Feature of the B Cell Response in Multiple Sclerosis Cerebrospinal Fluid
J. Immunol., September 1, 2003; 171(5): 2725 - 2733.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Nzula, J. J. Going, and D. I. Stott
Antigen-driven Clonal Proliferation, Somatic Hypermutation, and Selection of B Lymphocytes Infiltrating Human Ductal Breast Carcinomas
Cancer Res., June 15, 2003; 63(12): 3275 - 3280.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Orchard, R. Garand, Z. Davis, G. Babbage, S. Sahota, E. Matutes, D. Catovsky, P. W. Thomas, H. Avet-Loiseau, and D. Oscier
A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease
Blood, June 15, 2003; 101(12): 4975 - 4981.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
S. Hashiguchi, T. Nakashima, A. Nitani, T. Yoshihara, K. Yoshinaga, Y. Ito, Y. Maeda, and K. Sugimura
Human Fc{varepsilon}RI{alpha}-Specific Human Single-Chain Fv (scFv) Antibody with Antagonistic Activity toward IgE/Fc{varepsilon}RI{alpha}-Binding
J. Biochem., January 1, 2003; 133(1): 43 - 49.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Goebel, A. Montalbano, N. Ayers, E. Kompfner, L. Dickinson, C. F. Webb, and A. J. Feeney
High Frequency of Matrix Attachment Regions and Cut-Like Protein x/CCAAT-Displacement Protein and B Cell Regulator of IgH Transcription Binding Sites Flanking Ig V Region Genes
J. Immunol., September 1, 2002; 169(5): 2477 - 2487.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. H. Roark, J. B. Bussel, D. B. Cines, and D. L. Siegel
Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation
Blood, July 30, 2002; 100(4): 1388 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. Oberacher, P. J. Oefner, G. Holzl, A. Premstaller, K. Davis, and C. G. Huber
Re-sequencing of multiple single nucleotide polymorphisms by liquid chromatography-electrospray ionization mass spectrometry
Nucleic Acids Res., July 15, 2002; 30(14): e67 - e67.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
V C Thoree, S J C Golby, L Boursier, M Hackett, D K Dunn-Walters, J D Sanderson, and J Spencer
Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis
Gut, July 1, 2002; 51(1): 44 - 50.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. S. Yavuz, P. E. Lipsky, S. Yavuz, D. D. Metcalfe, and C. Akin
Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene
Blood, June 28, 2002; 100(2): 661 - 665.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. R. Edwards, W. Brouwer, C. H. Y. Choi, J. Ruhno, R. L. Ward, and A. M. Collins
Analysis of IgE Antibodies from a Patient with Atopic Dermatitis: Biased V Gene Usage and Evidence for Polyreactive IgE Heavy Chain Complementarity-Determining Region 3
J. Immunol., June 15, 2002; 168(12): 6305 - 6313.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Yu, A. Taghva, and M. R. Lieber
The Cleavage Efficiency of the Human Immunoglobulin Heavy Chain VH Elements by the RAG Complex. IMPLICATIONS FOR THE IMMUNE REPERTOIRE
J. Biol. Chem., February 8, 2002; 277(7): 5040 - 5046.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. W. Schroeder Jr, L. Zhang, and J. B. Philips III
Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life
Blood, November 1, 2001; 98(9): 2745 - 2751.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Leithauser, M. Bauerle, M. Q. Huynh, and P. Moller
Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma
Blood, November 1, 2001; 98(9): 2762 - 2770.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. I. D. Rossi, K. L. Medina, K. Garrett, G. Kolar, P. C. Comp, L. D. Shultz, J. D. Capra, P. Wilson, A. Schipul, and P. W. Kincade
Relatively Normal Human Lymphopoiesis but Rapid Turnover of Newly Formed B Cells in Transplanted Nonobese Diabetic/SCID Mice
J. Immunol., September 15, 2001; 167(6): 3033 - 3042.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Meffre, M. Chiorazzi, and M. C. Nussenzweig
Circulating Human B Cells That Express Surrogate Light Chains Display a Unique Antibody Repertoire
J. Immunol., August 15, 2001; 167(4): 2151 - 2156.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Marasca, P. Vaccari, M. Luppi, P. Zucchini, I. Castelli, P. Barozzi, A. Cuoghi, and G. Torelli
Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma
Am. J. Pathol., July 1, 2001; 159(1): 253 - 261.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Y. Mortuza, I. M. Moreira, M. Papaioannou, P. Gameiro, L. A. Coyle, C. S. Gricks, P. Amlot, H. G. Prentice, A. Madrigal, A. V. Hoffbrand, et al.
Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of JH-proximal variable gene segments
Blood, May 1, 2001; 97(9): 2716 - 2726.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Zemlin, K. Bauer, M. Hummel, S. Pfeiffer, S. Devers, C. Zemlin, H. Stein, and H. T. Versmold
The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage
Blood, March 1, 2001; 97(5): 1511 - 1513.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. H. Chan, K. G. Hadlock, S. K. H. Foung, and S. Levy
VH1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen
Blood, February 15, 2001; 97(4): 1023 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. H. Lucas, K. D. Moulton, V. R. Tang, and D. C. Reason
Combinatorial Library Cloning of Human Antibodies to Streptococcus pneumoniae Capsular Polysaccharides: Variable Region Primary Structures and Evidence for Somatic Mutation of Fab Fragments Specific for Capsular Serotypes 6B, 14, and 23F
Infect. Immun., February 1, 2001; 69(2): 853 - 864.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Welzel, T. Le, R. Marculescu, G. Mitterbauer, A. Chott, C. Pott, M. Kneba, M.-Q. Du, R. Kusec, J. Drach, et al.
Templated Nucleotide Addition and Immunoglobulin JH-Gene Utilization in t(11;14) Junctions: Implications for the Mechanism of Translocation and the Origin of Mantle Cell Lymphoma
Cancer Res., February 1, 2001; 61(4): 1629 - 1636.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. Oprea, L. G. Cowell, and T. B. Kepler
The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation
J. Immunol., January 15, 2001; 166(2): 892 - 899.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. H. Rowley, S. T. Shulman, B. T. Spike, C. A. Mask, and S. C. Baker
Oligoclonal IgA Response in the Vascular Wall in Acute Kawasaki Disease
J. Immunol., January 15, 2001; 166(2): 1334 - 1343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. F. Widhopf II and T. J. Kipps
Normal B Cells Express 51p1-Encoded Ig Heavy Chains That Are Distinct From Those Expressed by Chronic Lymphocytic Leukemia B Cells
J. Immunol., January 1, 2001; 166(1): 95 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. J. Girschick, A. C. Grammer, T. Nanki, M. Mayo, and P. E. Lipsky
RAG1 and RAG2 Expression by B Cell Subsets from Human Tonsil and Peripheral Blood
J. Immunol., January 1, 2001; 166(1): 377 - 386.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Lee, N. L. Monson, and P. E. Lipsky
The V{lambda}J{lambda} Repertoire in Human Fetal Spleen: Evidence for Positive Selection and Extensive Receptor Editing
J. Immunol., December 1, 2000; 165(11): 6322 - 6333.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Odendahl, A. Jacobi, A. Hansen, E. Feist, F. Hiepe, G. R. Burmester, P. E. Lipsky, A. Radbruch, and T. Dorner
Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus
J. Immunol., November 15, 2000; 165(10): 5970 - 5979.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. W. Bahler, N. S. Aguilera, C. C. Chen, S. L. Abbondanzo, and S. H. Swerdlow
Histological and Immunoglobulin VH Gene Analysis of Interfollicular Small Lymphocytic Lymphoma Provides Evidence for Two Types
Am. J. Pathol., October 1, 2000; 157(4): 1063 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
H.-P. Brezinschek, T. Dorner, N. L. Monson, R. I. Brezinschek, and P. E. Lipsky
The influence of CD40-CD154 interactions on the expressed human VH repertoire: analysis of VH genes expressed by individual B cells of a patient with X-linked hyper-IgM syndrome
Int. Immunol., June 1, 2000; 12(6): 767 - 775.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
D. Tewari
Clonal Analysis of the Human B-Cell Repertoire Using a Heteromobility Assay
Clin. Vaccine Immunol., May 1, 2000; 7(3): 507 - 509.
[Abstract] [Full Text] [PDF]

Home page
 Blood