| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 154, Issue 9 4414-4422, Copyright © 1995 by American Association of Immunologists
ARTICLES |
NP Restifo, I Bacik, KR Irvine, JW Yewdell, BJ McCabe, RW Anderson, LC Eisenlohr, SA Rosenberg and JR Bennink
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
CD8+ T lymphocytes (TCD8+) play an important role in cellular immune responses. TCD8+ recognize MHC class I molecules complexed to peptides of 8 to 10 residues derived largely from cytosolic proteins. Proteins are generally thought to be fragmented in the cytoplasm and delivered to nascent class I molecules in the endoplasmic reticulum (ER) by a peptide transporter encoded by the MHC. To explore the extent to which TCD8+ induction in vivo is limited by proteolysis or peptide transport into the ER, mice were immunized with recombinant vaccinia viruses containing mini-genes encoding antigenic peptides (bypassing the need for proteolysis), or these peptides with a NH2-terminal ER insertion sequence (bypassing the requirements for both proteolysis and transport). Additionally, mice were immunized with recombinant vaccinia viruses encoding rapidly degraded fragments of proteins. We report that limitations in induction of TCD8+ responses vary among Ags: for some, full length proteins are as immunogenic as other forms tested; for others, maximal responses are induced by peptides or by peptides targeted to the ER. Most importantly, in every circumstance examined, targeting peptides to the ER never diminished, and in some cases greatly enhanced, the TCD8+ immune response and provide an important alternative strategy in the design of live viral or naked DNA vaccines for the treatment of cancer and infectious diseases.
This article has been cited by other articles:
|
|
 |
|
  C. F. Towne, I. A. York, J. Neijssen, M. L. Karow, A. J. Murphy, D. M. Valenzuela, G. D. Yancopoulos, J. J. Neefjes, and K. L. Rock Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections J. Immunol., February 1, 2008; 180(3): 1704 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Goldwich, S. S. C. Hahn, S. Schreiber, S. Meier, E. Kampgen, R. Wagner, M. B. Lutz, and U. Schubert Targeting HIV-1 Gag into the Defective Ribosomal Product Pathway Enhances MHC Class I Antigen Presentation and CD8+ T Cell Activation J. Immunol., January 1, 2008; 180(1): 372 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Fischer, D. C. Tscharke, K. B. Donohue, M. E. Truckenmiller, and C. C. Norbury Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming J. Gen. Virol., September 1, 2007; 88(9): 2378 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Towne, I. A. York, L. B. Watkin, J. S. Lazo, and K. L. Rock Analysis of the Role of Bleomycin Hydrolase in Antigen Presentation and the Generation of CD8 T Cell Responses J. Immunol., June 1, 2007; 178(11): 6923 - 6930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Hogan, D. O. Co, J. Karman, E. Heninger, M. Suresh, and M. Sandor Virally Activated CD8 T Cells Home to Mycobacterium bovis BCG-Induced Granulomas but Enhance Antimycobacterial Protection Only in Immunodeficient Mice Infect. Immun., March 1, 2007; 75(3): 1154 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. F. Hermans, J. D. Silk, U. Gileadi, S. H. Masri, D. Shepherd, K. J. Farrand, M. Salio, and V. Cerundolo Dendritic Cell Function Can Be Modulated through Cooperative Actions of TLR Ligands and Invariant NKT Cells J. Immunol., March 1, 2007; 178(5): 2721 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. York, M. A. Brehm, S. Zendzian, C. F. Towne, and K. L. Rock Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance PNAS, June 13, 2006; 103(24): 9202 - 9207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. O. Atherly, M. A. Brehm, R. M. Welsh, and L. J. Berg Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help J. Immunol., February 1, 2006; 176(3): 1571 - 1581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Margalit, H. M. Sheikhet, Y. Carmi, D. Berko, E. Tzehoval, L. Eisenbach, and G. Gross Induction of Antitumor Immunity by CTL Epitopes Genetically Linked to Membrane-Anchored {beta}2-Microglobulin J. Immunol., January 1, 2006; 176(1): 217 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Towne, I. A. York, J. Neijssen, M. L. Karow, A. J. Murphy, D. M. Valenzuela, G. D. Yancopoulos, J. J. Neefjes, and K. L. Rock Leucine Aminopeptidase Is Not Essential for Trimming Peptides in the Cytosol or Generating Epitopes for MHC Class I Antigen Presentation J. Immunol., November 15, 2005; 175(10): 6605 - 6614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Pasquetto, H.-H. Bui, R. Giannino, F. Mirza, J. Sidney, C. Oseroff, D. C. Tscharke, K. Irvine, J. R. Bennink, B. Peters, et al. HLA-A*0201, HLA-A*1101, and HLA-B*0702 Transgenic Mice Recognize Numerous Poxvirus Determinants from a Wide Variety of Viral Gene Products J. Immunol., October 15, 2005; 175(8): 5504 - 5515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Palmer, S. Balasubramaniam, K.-i. Hanada, C. Wrzesinski, Z. Yu, S. Farid, M. R. Theoret, L. N. Hwang, C. A. Klebanoff, L. Gattinoni, et al. Vaccine-Stimulated, Adoptively Transferred CD8+ T Cells Traffic Indiscriminately and Ubiquitously while Mediating Specific Tumor Destruction J. Immunol., December 15, 2004; 173(12): 7209 - 7216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Johnstone, P. de Leon, F. Medina, J. A. Melero, B. Garcia-Barreno, and M. D. Val Shifting immunodominance pattern of two cytotoxic T-lymphocyte epitopes in the F glycoprotein of the Long strain of respiratory syncytial virus J. Gen. Virol., November 1, 2004; 85(11): 3229 - 3238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. J. Wong, C. B. Buck, X. Shen, and R. F. Siliciano An Evaluation of Enforced Rapid Proteasomal Degradation as a Means of Enhancing Vaccine-Induced CTL Responses J. Immunol., September 1, 2004; 173(5): 3073 - 3083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Norbury, S. Basta, K. B. Donohue, D. C. Tscharke, M. F. Princiotta, P. Berglund, J. Gibbs, J. R. Bennink, and J. W. Yewdell CD8+ T Cell Cross-Priming via Transfer of Proteasome Substrates Science, May 28, 2004; 304(5675): 1318 - 1321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Salio, M. J. Palmowski, A. Atzberger, I. F. Hermans, and V. Cerundolo CpG-matured Murine Plasmacytoid Dendritic Cells Are Capable of In Vivo Priming of Functional CD8 T Cell Responses to Endogenous but Not Exogenous Antigens J. Exp. Med., February 17, 2004; 199(4): 567 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Berg, E. Crossley, S. Murray, and J. Forman Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen J. Exp. Med., November 17, 2003; 198(10): 1583 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. F. Hermans, J. D. Silk, U. Gileadi, M. Salio, B. Mathew, G. Ritter, R. Schmidt, A. L. Harris, L. Old, and V. Cerundolo NKT Cells Enhance CD4+ and CD8+ T Cell Responses to Soluble Antigen In Vivo through Direct Interaction with Dendritic Cells J. Immunol., November 15, 2003; 171(10): 5140 - 5147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhong, P. A. Reche, C.-C. Lai, B. Reinhold, and E. L. Reinherz Genome-wide Characterization of a Viral Cytotoxic T Lymphocyte Epitope Repertoire J. Biol. Chem., November 14, 2003; 278(46): 45135 - 45144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Rosenberg, J. C. Yang, D. J. Schwartzentruber, P. Hwu, S. L. Topalian, R. M. Sherry, N. P. Restifo, J. R. Wunderlich, C. A. Seipp, L. Rogers-Freezer, et al. Recombinant Fowlpox Viruses Encoding the Anchor-modified gp100 Melanoma Antigen Can Generate Antitumor Immune Responses in Patients with Metastatic Melanoma Clin. Cancer Res., August 1, 2003; 9(8): 2973 - 2980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Touloukian, W. W. Leitner, R. E. Schnur, P. F. Robbins, Y. Li, S. Southwood, A. Sette, S. A. Rosenberg, and N. P. Restifo Normal Tissue Depresses While Tumor Tissue Enhances Human T Cell Responses In Vivo to a Novel Self/Tumor Melanoma Antigen, OA1 J. Immunol., February 1, 2003; 170(3): 1579 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Shen, S. B. J. Wong, C. B. Buck, J. Zhang, and R. F. Siliciano Direct Priming and Cross-Priming Contribute Differentially to the Induction of CD8+ CTL Following Exposure to Vaccinia Virus Via Different Routes J. Immunol., October 15, 2002; 169(8): 4222 - 4229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Paster, M. Kalat, M. Zehetner, and T. Schweighoffer Structural Elements of a Protein Antigen Determine Immunogenicity of the Embedded MHC Class I-Restricted T Cell Epitope J. Immunol., September 15, 2002; 169(6): 2937 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Probst, T. Dumrese, and M. F. van den Broek Cutting Edge: Competition for APC by CTLs of Different Specificities Is Not Functionally Important During Induction of Antiviral Responses J. Immunol., June 1, 2002; 168(11): 5387 - 5391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Parks and M. A. Alexander-Miller High avidity cytotoxic T lymphocytes to a foreign antigen are efficiently activated following immunization with a recombinant paramyxovirus, simian virus 5 J. Gen. Virol., May 1, 2002; 83(5): 1167 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Topham, M. R. Castrucci, F. S. Wingo, G. T. Belz, and P. C. Doherty The Role of Antigen in the Localization of Naive, Acutely Activated, and Memory CD8+ T Cells to the Lung During Influenza Pneumonia J. Immunol., December 15, 2001; 167(12): 6983 - 6990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Kedl, M. Jordan, T. Potter, J. Kappler, P. Marrack, and S. Dow CD40 stimulation accelerates deletion of tumor-specific CD8+ T cells in the absence of tumor-antigen vaccination PNAS, August 23, 2001; (2001) 191371898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Skoberne, R. Holtappels, H. Hof, and G. Geginat Dynamic Antigen Presentation Patterns of Listeria monocytogenes-Derived CD8 T Cell Epitopes In Vivo J. Immunol., August 15, 2001; 167(4): 2209 - 2218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Norbury, M. F. Princiotta, I. Bacik, R. R. Brutkiewicz, P. Wood, T. Elliott, J. R. Bennink, and J. W. Yewdell Multiple Antigen-Specific Processing Pathways for Activating Naive CD8+ T Cells In Vivo J. Immunol., April 1, 2001; 166(7): 4355 - 4362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sherritt, L. Cooper, D. J. Moss, N. Kienzle, J. Altman, and R. Khanna Immunization with tumor-associated epitopes fused to an endoplasmic reticulum translocation signal sequence affords protection against tumors with down-regulated expression of MHC and peptide transporters Int. Immunol., March 1, 2001; 13(3): 265 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J.R. Goulder, M. A. Altfeld, E. S. Rosenberg, T. Nguyen, Y. Tang, R. L. Eldridge, M. M. Addo, S. He, J. S. Mukherjee, M. N. Phillips, et al. Substantial Differences in Specificity of HIV-specific Cytotoxic T Cells in Acute and Chronic HIV Infection J. Exp. Med., January 8, 2001; 193(2): 181 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Kedl, W. A. Rees, D. A. Hildeman, B. Schaefer, T. Mitchell, J. Kappler, and P. Marrack T Cells Compete for Access to Antigen-bearing Antigen-presenting Cells J. Exp. Med., October 9, 2000; 192(8): 1105 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Crotzer, R. E. Christian, J. M. Brooks, J. Shabanowitz, R. E. Settlage, J. A. Marto, F. M. White, A. B. Rickinson, D. F. Hunt, and V. H. Engelhard Immunodominance Among EBV-Derived Epitopes Restricted by HLA-B27 Does Not Correlate with Epitope Abundance in EBV-Transformed B-Lymphoblastoid Cell Lines J. Immunol., June 15, 2000; 164(12): 6120 - 6129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Wherry, K. A. Puorro, A. Porgador, and L. C. Eisenlohr The Induction of Virus-Specific CTL as a Function of Increasing Epitope Expression: Responses Rise Steadily Until Excessively High Levels of Epitope Are Attained J. Immunol., October 1, 1999; 163(7): 3735 - 3745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Stevenson, G. T. Belz, M. R. Castrucci, J. D. Altman, and P. C. Doherty A gamma -herpesvirus sneaks through a CD8+ T cell response primed to a lytic-phase epitope PNAS, August 3, 1999; 96(16): 9281 - 9286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Irvine, M. R. Parkhurst, E. P. Shulman, J. P. Tupesis, M. Custer, C. E. Touloukian, P. F. Robbins, A. G. Yafal, P. Greenhalgh, R. P. M. Sutmuller, et al. Recombinant Virus Vaccination against "Self" Antigens UsingAnchor-fixed Immunogens Cancer Res., June 1, 1999; 59(11): 2536 - 2540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Agadjanyan, J. J. Kim, N. Trivedi, D. M. Wilson, B. Monzavi-Karbassi, L. D. Morrison, L. K. Nottingham, T. Dentchev, A. Tsai, K. Dang, et al. CD86 (B7-2) Can Function to Drive MHC-Restricted Antigen-Specific CTL Responses In Vivo J. Immunol., March 15, 1999; 162(6): 3417 - 3427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vijh, I. M. Pilip, and E. G. Pamer Noncompetitive Expansion of Cytotoxic T Lymphocytes Specific for Different Antigens during Bacterial Infection Infect. Immun., March 1, 1999; 67(3): 1303 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. F. Greten and E. M. Jaffee Cancer Vaccines J. Clin. Oncol., March 1, 1999; 17(3): 1047 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tobery and R. F. Siliciano Cutting Edge: Induction of Enhanced CTL-Dependent Protective Immunity In Vivo by N-End Rule Targeting of a Model Tumor Antigen J. Immunol., January 15, 1999; 162(2): 639 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Sigal, H. Reiser, and K. L. Rock The Role of B7-1 and B7-2 Costimulation for the Generation of CTL Responses In Vivo J. Immunol., September 15, 1998; 161(6): 2740 - 2745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. Overwijk, A. Tsung, K. R. Irvine, M. R. Parkhurst, T. J. Goletz, K. Tsung, M. W. Carroll, C. Liu, B. Moss, S. A. Rosenberg, et al. gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of "Self"-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand J. Exp. Med., July 20, 1998; 188(2): 277 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mandl, L. J. Sigal, K. L. Rock, and R. Andino Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen PNAS, July 7, 1998; 95(14): 8216 - 8221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Rodriguez, L. L. An, S. Harkins, J. Zhang, M. Yokoyama, G. Widera, J. T. Fuller, C. Kincaid, I. L. Campbell, and J. L. Whitton DNA Immunization with Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination J. Virol., June 1, 1998; 72(6): 5174 - 5181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Anton, H. L. Snyder, J. R. Bennink, A. Vinitsky, M. Orlowski, A. Porgador, and J. W. Yewdell Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides J. Immunol., May 15, 1998; 160(10): 4859 - 4868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vijh, I. M. Pilip, and E. G. Pamer Effect of Antigen-Processing Efficiency on In Vivo T Cell Response Magnitudes J. Immunol., April 15, 1998; 160(8): 3971 - 3977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-M. Fu, L. M. Mylin, T. D. Schell, I. Bacik, G. Russ, J. W. Yewdell, J. R. Bennink, and S. S. Tevethia An Endoplasmic Reticulum-Targeting Signal Sequence Enhances the Immunogenicity of an Immunorecessive Simian Virus 40 Large T Antigen Cytotoxic T-Lymphocyte Epitope J. Virol., February 1, 1998; 72(2): 1469 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Snyder, I. Bacik, J. R. Bennink, G. Kearns, T. W. Behrens, T. Bachi, M. Orlowski, and J. W. Yewdell Two Novel Routes of Transporter Associated with Antigen Processing (TAP)-independent Major Histocompatibility Complex Class I Antigen Processing J. Exp. Med., October 6, 1997; 186(7): 1087 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Osanto Vaccine Trials for the Clinician: Prospects for Tumor Antigens Oncologist, October 1, 1997; 2(5): 284 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ben-Shahar, B. Cassouto, L. Novak, A. Porgador, and Y. Reiss Production of a Specific Major Histocompatibility Complex Class I-restricted Epitope by Ubiquitin-dependent Degradation of Modified Ovalbumin in Lymphocyte Lysate J. Biol. Chem., August 22, 1997; 272(34): 21060 - 21066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Tobery and R. F. Siliciano Targeting of HIV-1 Antigens for Rapid Intracellular Degradation Enhances Cytotoxic T Lymphocyte (CTL) Recognition and the Induction of De Novo CTL Responses In Vivo After Immunization J. Exp. Med., March 3, 1997; 185(5): 909 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Berwin, R. C. Reed, and C. V. Nicchitta Virally Induced Lytic Cell Death Elicits the Release of Immunogenic GRP94/gp96 J. Biol. Chem., June 8, 2001; 276(24): 21083 - 21088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Belz, P. G. Stevenson, M. R. Castrucci, J. D. Altman, and P. C. Doherty Postexposure vaccination massively increases the prevalence of gamma -herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice PNAS, March 14, 2000; 97(6): 2725 - 2730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Kedl, M. Jordan, T. Potter, J. Kappler, P. Marrack, and S. Dow CD40 stimulation accelerates deletion of tumor-specific CD8+ T cells in the absence of tumor-antigen vaccination PNAS, September 11, 2001; 98(19): 10811 - 10816. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
