| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 154, Issue 8 4039-4047, Copyright © 1995 by American Association of Immunologists
ARTICLES |
DL Durden, HM Kim, B Calore and Y Liu
Neil Bogart Memorial Laboratories, Division of Hematology-Oncology, Childrens Hospital Los Angeles, CA, USA.
U937 cells differentiated with IFN-gamma (termed U937IF cells) were used to study Fc gamma RI signaling. IFN induces a functional Fc gamma RI receptor signaling pathway in U937 cells, leading to the activation of the respiratory burst. IFN induces the expression of the nonreceptor protein tyrosine kinase, hck, and cross-linking the Fc gamma RI receptor in U937IF cells results in the activation of hck kinase as evidenced by the three- to fivefold increased tyrosine phosphorylation of hck. In vitro kinase assays demonstrate that the specific kinase activity of hck is increased 10-fold after Fc gamma RI stimulation. hck is observed to associate with two prominent tyrosine-phosphorylated proteins, p72 and p95, after Fc gamma RI-activation. Fc gamma RI cross- linking also results in mobility shift in MAP kinase in U937IF cells, suggesting that the Fc gamma RI receptor signals through the activation of MAP kinase. The data suggest that hck, p72, p95, and MAP kinase are involved in signal transduction through the Fc gamma RI receptor.
This article has been cited by other articles:
|
|
 |
|
  S. M. Wahl, T. Greenwell-Wild, G. Peng, G. Ma, J. M. Orenstein, and N. Vazquez Viral and host cofactors facilitate HIV-1 replication in macrophages J. Leukoc. Biol., November 1, 2003; 74(5): 726 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wen, S.-T. Jou, Y. Chen, A. Hoffmeyer, and D. Wang Phospholipase C{gamma}2 Is Essential for Specific Functions of Fc{epsilon}R and Fc{gamma}R J. Immunol., December 15, 2002; 169(12): 6743 - 6752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Garcia-Garcia and C. Rosales Signal transduction during Fc receptor-mediated phagocytosis J. Leukoc. Biol., December 1, 2002; 72(6): 1092 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. O. C. Cory, R. Garg, R. Cramer, and A. J. Ridley Phosphorylation of Tyrosine 291 Enhances the Ability of WASp to Stimulate Actin Polymerization and Filopodium Formation J. Biol. Chem., November 15, 2002; 277(47): 45115 - 45121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Edberg, H. Qin, A. W. Gibson, A. M. F. Yee, P. B. Redecha, Z. K. Indik, A. D. Schreiber, and R. P. Kimberly The CY Domain of the Fcgamma RIa alpha -Chain (CD64) Alters gamma -Chain Tyrosine-based Signaling and Phagocytosis J. Biol. Chem., October 18, 2002; 277(43): 41287 - 41293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fernandez, M. Renedo, C. Garcia-Rodriguez, and M. Sanchez Crespo Activation of Monocytic Cells Through Fc{gamma} Receptors Induces the Expression of Macrophage-Inflammatory Protein (MIP)-1{alpha}, MIP-1{beta}, and RANTES J. Immunol., September 15, 2002; 169(6): 3321 - 3328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Kant, P. De, X. Peng, T. Yi, D. J. Rawlings, J. S. Kim, and D. L. Durden SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC Blood, August 13, 2002; 100(5): 1852 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hu, A. Punturieri, J. Todt, J. Sonstein, T. Polak, and J. L. Curtis Recognition and phagocytosis of apoptotic T cells by resident murine tissue macrophages require multiple signal transduction events J. Leukoc. Biol., May 1, 2002; 71(5): 881 - 889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Kim, X. Peng, P. K. De, R. L. Geahlen, and D. L. Durden PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac Blood, January 15, 2002; 99(2): 694 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Majeed, E. Caveggion, C. A. Lowell, and G. Berton Role of Src kinases and Syk in Fc{gamma} receptor-mediated phagocytosis and phagosome-lysosome fusion J. Leukoc. Biol., November 1, 2001; 70(5): 801 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Garcia-Garcia, G. Sanchez-Mejorada, and C. Rosales Phosphatidylinositol 3-kinase and ERK are required for NF-{kappa}B activation but not for phagocytosis J. Leukoc. Biol., October 1, 2001; 70(4): 649 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Choi, H. S. Jun, H. N. Kim, H. J. Park, Y. W. Eom, H. L. Noh, H. Kwon, H. M. Kim, and J. W. Yoon Role of Hck in the Pathogenesis of Encephalomyocarditis Virus-Induced Diabetes in Mice J. Virol., February 15, 2001; 75(4): 1949 - 1957. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. J. Bruce-Keller, J. L. Keeling, J. N. Keller, F. F. Huang, S. Camondola, and M. P. Mattson Antiinflammatory Effects of Estrogen on Microglial Activation Endocrinology, October 1, 2000; 141(10): 3646 - 3656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Aittomaki, M. Pesu, B. Groner, O. A. Janne, J. J. Palvimo, and O. Silvennoinen Cooperation Among Stat1, Glucocorticoid Receptor, and PU.1 in Transcriptional Activation of the High-Affinity Fc{gamma} Receptor I in Monocytes J. Immunol., June 1, 2000; 164(11): 5689 - 5697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Erdreich-Epstein, H. Shimada, S. Groshen, M. Liu, L. S. Metelitsa, K. S. Kim, M. F. Stins, R. C. Seeger, and D. L. Durden Integrins {{alpha}}v{beta}3 and {{alpha}}v{beta}5 Are Expressed by Endothelium of High-Risk Neuroblastoma and Their Inhibition Is Associated with Increased Endogenous Ceramide Cancer Res., February 1, 2000; 60(3): 712 - 721. [Abstract] [Full Text]
|
|
|
|
|
|
M. Foti, L. Cartier, V. Piguet, D. P. Lew, J.-L. Carpentier, D. Trono, and K.-H. Krause The HIV Nef Protein Alters Ca2+ Signaling in Myelomonocytic Cells through SH3-mediated Protein-Protein Interactions J. Biol. Chem., December 3, 1999; 274(49): 34765 - 34772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-K. Park, A. Erdreich-Epstein, M. Liu, K. D. Izadi, and D. L. Durden High Affinity IgG Receptor Activation of Src Family Kinases Is Required for Modulation of the Shc-Grb2-Sos Complex and the Downstream Activation of the Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase J. Immunol., December 1, 1999; 163(11): 6023 - 6034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-K. Park, K. D. Izadi, Y. M. Deo, and D. L. Durden Role of Src in the Modulation of Multiple Adaptor Proteins in Fcalpha RI Oxidant Signaling Blood, September 15, 1999; 94(6): 2112 - 2120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Briggs and T. E. Smithgall SH2-Kinase Linker Mutations Release Hck Tyrosine Kinase and Transforming Activities in Rat-2 Fibroblasts J. Biol. Chem., September 10, 1999; 274(37): 26579 - 26583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pricop, J. Gokhale, P. Redecha, S. C. Ng, and J. E. Salmon Reactive Oxygen Intermediates Enhance Fc{gamma} Receptor Signaling and Amplify Phagocytic Capacity J. Immunol., June 15, 1999; 162(12): 7041 - 7048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Dong, K. A. Siminovitch, L. Fialkow, T. Fukushima, and G. P. Downey Negative Regulation of Myeloid Cell Proliferation and Function by the SH2 Domain-Containing Tyrosine Phosphatase-1 J. Immunol., March 15, 1999; 162(6): 3220 - 3230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hauses, R. R. Tonjes, and M. Grez The Transcription Factor Sp1 Regulates the Myeloid-specific Expression of the Human Hematopoietic Cell Kinase (HCK) Gene through Binding to Two Adjacent GC Boxes within the HCK Promoter-Proximal Region J. Biol. Chem., November 27, 1998; 273(48): 31844 - 31852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. D. McGilvray, Z. Lu, A. C. Wei, A. P. B. Dackiw, J. C. Marshall, A. Kapus, G. Levy, and O. D. Rotstein Murine Hepatitis Virus Strain 3 Induces the Macrophage Prothrombinase fgl-2 through p38 Mitogen-activated Protein Kinase Activation J. Biol. Chem., November 27, 1998; 273(48): 32222 - 32229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Kyono, R. de Jong, R. Kil Park, Y. Liu, N. Heisterkamp, J. Groffen, and D. L. Durden Differential Interaction of Crkl with Cbl or C3G, Hef-1, and {gamma} Subunit Immunoreceptor Tyrosine-Based Activation Motif in Signaling of Myeloid High Affinity Fc Receptor for IgG (Fc{gamma}RI) J. Immunol., November 15, 1998; 161(10): 5555 - 5563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sanchez-Mejorada and C. Rosales Fcgamma Receptor-mediated Mitogen-activated Protein Kinase Activation in Monocytes Is Independent of Ras J. Biol. Chem., October 16, 1998; 273(42): 27610 - 27619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Lowry, A.-M. Duchemin, K. M. Coggeshall, J. M. Robinson, and C. L. Anderson Chimeric Receptors Composed of Phosphoinositide 3-Kinase Domains and Fcgamma Receptor Ligand-binding Domains Mediate Phagocytosis in COS Fibroblasts J. Biol. Chem., September 18, 1998; 273(38): 24513 - 24520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chu, Y. Liu, G. A. Koretzky, and D. L. Durden SLP-76-Cbl-Grb2-Shc Interactions in Fcgamma RI Signaling Blood, September 1, 1998; 92(5): 1697 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. McDonald, M. E. Bamberger, C. K. Combs, and G. E. Landreth beta -Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes J. Neurosci., June 15, 1998; 18(12): 4451 - 4460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Park, W. T. Kyono, Y. Liu, and D. L. Durden CBL-GRB2 Interaction in Myeloid Immunoreceptor Tyrosine Activation Motif Signaling J. Immunol., May 15, 1998; 160(10): 5018 - 5027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Briggs, M. Sharkey, M. Stevenson, and T. E. Smithgall SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1 J. Biol. Chem., July 18, 1997; 272(29): 17899 - 17902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. D. McGilvray, Z. Lu, R. Bitar, A. P.B. Dackiw, C. J. Davreux, and O. D. Rotstein VLA-4 Integrin Cross-linking on Human Monocytic THP-1 Cells Induces Tissue Factor Expression by a Mechanism Involving Mitogen-activated Protein Kinase J. Biol. Chem., April 11, 1997; 272(15): 10287 - 10294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Taylor, T. Jahn, S. Smith, T. Lamkin, L. Uribe, Y. Liu, D. L. Durden, and K. Weinberg Differential Activation of the Tyrosine Kinases ZAP-70 and Syk After Fcgamma RI Stimulation Blood, January 15, 1997; 89(2): 388 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Welch and I. Maridonneau-Parini Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes J. Biol. Chem., January 3, 1997; 272(1): 102 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ernst, A. Oates, and A. R. Dunn gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways J. Biol. Chem., November 22, 1996; 271(47): 30136 - 30143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Park, Y. Liu, and D. L. Durden A Role for Shc, Grb2, and Raf-1 in Fcgamma RI Signal Relay J. Biol. Chem., June 7, 1996; 271(23): 13342 - 13348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hassaine, M. Courcoul, G. Bessou, Y. Barthalay, C. Picard, D. Olive, Y. Collette, R. Vigne, and E. Decroly The Tyrosine Kinase Hck Is an Inhibitor of HIV-1 Replication Counteracted by the Viral Vif Protein J. Biol. Chem., May 11, 2001; 276(20): 16885 - 16893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Briggs, B. Scholtz, J.-M. Jacque, S. Swingler, M. Stevenson, and T. E. Smithgall HIV-1 Nef Promotes Survival of Myeloid Cells by a Stat3-dependent Pathway J. Biol. Chem., June 29, 2001; 276(27): 25605 - 25611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tridandapani, T. W. Lyden, J. L. Smith, J. E. Carter, K. M. Coggeshall, and C. L. Anderson The Adapter Protein LAT Enhances Fcgamma Receptor-mediated Signal Transduction in Myeloid Cells J. Biol. Chem., June 30, 2000; 275(27): 20480 - 20487. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
