The Journal of Immunology, Vol 154, Issue 8 3806-3813, Copyright © 1995 by American Association of Immunologists

ARTICLES

Expression of the Fas ligand in cells of T cell lineage

T Suda, T Okazaki, Y Naito, T Yokota, N Arai, S Ozaki, K Nakao and S Nagata
Department of Molecular Biology, Osaka Bioscience Institute, Japan.

Fas ligand (FasL) is a membrane-type cytokine belonging to the TNF family, and induces apoptosis through its cell-surface receptor, Fas. To determine the cell types that express FasL, various mouse tissues and cell lines were examined by Northern hybridization using a mouse FasL cDNA as a probe. Among tissues, lymphoid organs (thymus, lymph node, spleen), lung, and small intestine express low levels of FasL mRNA, suggesting the role of FasL in the general immune system and mucosal immunity. The testis expressed FasL mRNA most abundantly; however, the size of FasL mRNA in the testis was slightly shorter than those in other tissues. Distribution of FasL mRNA in a panel of cell lines indicated that the FasL expression is rather restricted to the cells of T cell lineage. Activation of the splenocytes with the T cell activators such as PMA and ionomycin, Con A, anti-CD3, or even IL-2 alone induced the expression of the FasL. CD8+ splenocytes expressed the FasL more abundantly than did the CD4+ splenocytes upon activation by Con A and IL-2. Among CD4+ CTL cell lines, the FasL was expressed in all Th1 and Th0, and some Th2 clones.

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				J.-K. Lee, T. J. Sayers, A. D. Brooks, T. C. Back, H. A. Young, K. L. Komschlies, J. M. Wigginton, and R. H. Wiltrout IFN-{gamma}-Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells J. Immunol., January 1, 2000; 164(1): 231 - 239. [Abstract] [Full Text] [PDF]

				M. R. M. van den Brink, E. Moore, K. J. Horndasch, J. M. Crawford, J. Hoffman, G. F. Murphy, and S. J. Burakoff Fas-Deficient lpr Mice Are More Susceptible to Graft-Versus-Host Disease J. Immunol., January 1, 2000; 164(1): 469 - 480. [Abstract] [Full Text] [PDF]

				H. Suzuki, Y. W. Zhou, M. Kato, T. W. Mak, and I. Nakashima Normal Regulatory {alpha}/{beta} T Cells Effectively Eliminate Abnormally Activated T Cells Lacking the Interleukin 2 Receptor {beta} in Vivo J. Exp. Med., December 6, 1999; 190(11): 1561 - 1572. [Abstract] [Full Text] [PDF]

				I. Tuominen, M. Vesaluoma, A.-M. Teppo, C. Gronhagen-Riska, and T. Tervo Soluble Fas and Fas ligand in human tear fluid after photorefractive keratectomy Br J Ophthalmol, December 1, 1999; 83(12): 1360 - 1363. [Abstract] [Full Text] [PDF]

				J. E. CARDIER, T. SCHULTE, H. KAMMER, J. KWAK, and M. CARDIER Fas (CD95, APO-1) antigen expression and function in murine liver endothelial cells: implications for the regulation of apoptosis in liver endothelial cells FASEB J, November 1, 1999; 13(14): 1950 - 1960. [Abstract] [Full Text]

				E. Schneider, G. Moreau, A. Arnould, F. Vasseur, N. Khodabaccus, M. Dy, and S. Ezine Increased Fetal and Extramedullary Hematopoiesis in Fas-Deficient C57BL/6-lpr/lpr Mice Blood, October 15, 1999; 94(8): 2613 - 2621. [Abstract] [Full Text] [PDF]

				N. Koide, K. Narita, Y. Kato, T. Sugiyama, D. Chakravortty, A. Morikawa, T. Yoshida, and T. Yokochi Expression of Fas and Fas Ligand on Mouse Renal Tubular Epithelial Cells in the Generalized Shwartzman Reaction and Its Relationship to Apoptosis Infect. Immun., August 1, 1999; 67(8): 4112 - 4118. [Abstract] [Full Text] [PDF]

				J.A. Garcia-Velasco, A. Arici, T. Zreik, F. Naftolin, and G. Mor Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis Mol. Hum. Reprod., July 1, 1999; 5(7): 642 - 650. [Abstract] [Full Text] [PDF]

				C. Kakinuma, K. Takagaki, T. Yatomi, N. Nakamura, S. Nagata, A. Uemura, and Y. Shibutani Acute Toxicity of an Anti-Fas Antibody in Mice Toxicol Pathol, July 1, 1999; 27(4): 412 - 420. [Abstract] [PDF]

				S. A. Huber, J. Kupperman, and M. K. Newell Hormonal Regulation of CD4+ T-Cell Responses in Coxsackievirus B3-Induced Myocarditis in Mice J. Virol., June 1, 1999; 73(6): 4689 - 4695. [Abstract] [Full Text]

				S. W. Kauma, T. F. Huff, N. Hayes, and A. Nilkaeo Placental Fas Ligand Expression Is a Mechanism for Maternal Immune Tolerance to the Fetus J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 2188 - 2194. [Abstract] [Full Text]

				K. Miwa, H. Hashimoto, T. Yatomi, N. Nakamura, S. Nagata, and T. Suda Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease Int. Immunol., June 1, 1999; 11(6): 925 - 931. [Abstract] [Full Text] [PDF]

				B. N. Dittel, R. M. Merchant, and C. A. Janeway Jr. Evidence for Fas-Dependent and Fas-Independent Mechanisms in the Pathogenesis of Experimental Autoimmune Encephalomyelitis J. Immunol., June 1, 1999; 162(11): 6392 - 6400. [Abstract] [Full Text] [PDF]

				T. A. Phillips, J. Ni, G. Pan, S. M. Ruben, Y.-F. Wei, J. L. Pace, and J. S. Hunt TRAIL (Apo-2L) and TRAIL Receptors in Human Placentas: Implications for Immune Privilege J. Immunol., May 15, 1999; 162(10): 6053 - 6059. [Abstract] [Full Text] [PDF]

				M. T. Abreu-Martin, A. A. Palladino, M. Faris, N. M. Carramanzana, A. E. Nel, and S. R. Targan Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G599 - G605. [Abstract] [Full Text] [PDF]

				I. Saito, K. Haruta, M. Shimuta, H. Inoue, H. Sakurai, K. Yamada, N. Ishimaru, H. Higashiyama, T. Sumida, H. Ishida, et al. Fas Ligand-Mediated Exocrinopathy Resembling Sjogren's Syndrome in Mice Transgenic for IL-10 J. Immunol., March 1, 1999; 162(5): 2488 - 2494. [Abstract] [Full Text] [PDF]

				N. Kayagaki, N. Yamaguchi, M. Nakayama, A. Kawasaki, H. Akiba, K. Okumura, and H. Yagita Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity J. Immunol., March 1, 1999; 162(5): 2639 - 2647. [Abstract] [Full Text] [PDF]

				M. Ghio, P. Contini, C. Mazzei, S. Brenci, G. Barberis, G. Filaci, F. Indiveri, and F. Puppo Soluble HLA Class I, HLA Class II, and Fas Ligand in Blood Components: A Possible Key to Explain the Immunomodulatory Effects of Allogeneic Blood Transfusions Blood, March 1, 1999; 93(5): 1770 - 1777. [Abstract] [Full Text] [PDF]

				I. Woolveridge, M. de Boer-Brouwer, M. F. Taylor, K. J. Teerds, F. C.W. Wu, and I. D. Morris Apoptosis in the Rat Spermatogenic Epithelium Following Androgen Withdrawal: Changes in Apoptosis-Related Genes Biol Reprod, February 1, 1999; 60(2): 461 - 470. [Abstract] [Full Text] [PDF]

				M. Weiss, L. L. Moldawer, and E. M. Schneider Granulocyte Colony-Stimulating Factor to Prevent the Progression of Systemic Nonresponsiveness in Systemic Inflammatory Response Syndrome and Sepsis Blood, January 15, 1999; 93(2): 425 - 439. [Full Text] [PDF]

				W. C. Brown, T. F. McElwain, G. H. Palmer, S. E. Chantler, and D. M. Estes Bovine CD4+ T-Lymphocyte Clones Specific for Rhoptry-Associated Protein 1 of Babesia bigemina Stimulate Enhanced Immunoglobulin G1 (IgG1) and IgG2 Synthesis Infect. Immun., January 1, 1999; 67(1): 155 - 164. [Abstract] [Full Text] [PDF]

				W. E. Fogler, K. Volker, M. Watanabe, J. M. Wigginton, P. Roessler, M. J. Brunda, J. R. Ortaldo, and R. H. Wiltrout Recruitment of Hepatic NK Cells by IL-12 Is Dependent on IFN-{gamma} and VCAM-1 and Is Rapidly Down-Regulated by a Mechanism Involving T Cells and Expression of Fas J. Immunol., December 1, 1998; 161(11): 6014 - 6021. [Abstract] [Full Text] [PDF]

				E. Ayroldi, O. Zollo, L. Cannarile, F. D' Adamio, U. Grohmann, D. V. Delfino, and C. Riccardi Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2-Independent Inhibition of Fas/fasL Expression and Cell Death Blood, December 1, 1998; 92(11): 4212 - 4219. [Abstract] [Full Text] [PDF]

				J.-h. Li, D. Rosen, D. Ronen, C. K. Behrens, P. H. Krammer, W. R. Clark, and G. Berke The Regulation of CD95 Ligand Expression and Function in CTL J. Immunol., October 15, 1998; 161(8): 3943 - 3949. [Abstract] [Full Text] [PDF]