The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wechsler, R. J.
Right arrow Articles by Monroe, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wechsler, R. J.
Right arrow Articles by Monroe, J. G.

The Journal of Immunology, Vol 154, Issue 7 3234-3244, Copyright © 1995 by American Association of Immunologists

ARTICLES

src-family tyrosine kinase p55fgr is expressed in murine splenic B cells and is activated in response to antigen receptor cross-linking

RJ Wechsler and JG Monroe
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104.

Stimulation of the B cell Ag receptor (BCR) triggers a complex cascade of intracellular signals that lead to activation, proliferation, and differentiation. One of the earliest and most critical events following Ag receptor cross-linking is the activation of receptor-associated tyrosine kinases, which phosphorylate a variety of substrates involved in transducing signals generated through the receptor. Several tyrosine kinases have been shown to be associated with the BCR, including the src family members Lyn, Fyn, Blk, and Lck and the non-src kinase Syk. Here we describe another src family kinase expressed in B cells, p55fgr. Although previous studies have suggested that Fgr expression in the mouse is restricted to cells of the myeloid lineage, we demonstrate that highly purified murine splenic B cells express the kinase as well. We also show that Fgr, like other B cell kinases, is activated in response to cross-linking of the Ag receptor. Unlike these other kinases, however, Fgr does not appear to be physically associated with the receptor, and does not become activated until several minutes after stimulation. Moreover, we find that Fgr is associated with a distinct set of cellular proteins. On the basis of these studies, we hypothesize that Fgr may play a unique role in the BCR-associated signaling pathway.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
V. Chew and K.-P. Lam
Leupaxin Negatively Regulates B Cell Receptor Signaling
J. Biol. Chem., September 14, 2007; 282(37): 27181 - 27191.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Lyubchenko, J. Dal Porto, J. C. Cambier, and V. M. Holers
Coligation of the B Cell Receptor with Complement Receptor Type 2 (CR2/CD21) Using Its Natural Ligand C3dg: Activation without Engagement of an Inhibitory Signaling Pathway
J. Immunol., March 15, 2005; 174(6): 3264 - 3272.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. K. Mirnics, E. Caudell, Y. Gao, K. Kuwahara, N. Sakaguchi, T. Kurosaki, J. Burnside, K. Mirnics, and S. J. Corey
Microarray Analysis of Lyn-Deficient B Cells Reveals Germinal Center-Associated Nuclear Protein and Other Genes Associated with the Lymphoid Germinal Center
J. Immunol., April 1, 2004; 172(7): 4133 - 4141.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Yokozeki, K. Adler, D. Lankar, and C. Bonnerot
B Cell Receptor-Mediated Syk-Independent Activation of Phosphatidylinositol 3-Kinase, Ras, and Mitogen-Activated Protein Kinase Pathways
J. Immunol., August 1, 2003; 171(3): 1328 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Vicentini, P. Mazzi, E. Caveggion, S. Continolo, L. Fumagalli, J. A. Lapinet-Vera, C. A. Lowell, and G. Berton
Fgr Deficiency Results in Defective Eosinophil Recruitment to the Lung During Allergic Airway Inflammation
J. Immunol., June 15, 2002; 168(12): 6446 - 6454.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. C. Sandel, M. Gendelman, G. Kelsoe, and J. G. Monroe
Definition of a Novel Cellular Constituent of the Bone Marrow That Regulates the Response of Immature B Cells to B Cell Antigen Receptor Engagement
J. Immunol., May 15, 2001; 166(10): 5935 - 5944.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. Horikawa, H. Nishizumi, H. Umemori, S. Aizawa, K. Takatsu, and T. Yamamoto
Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling
Int. Immunol., September 1, 1999; 11(9): 1441 - 1449.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-L. Li, M. S. Forman, T. Kurosaki, and E. Pure
Syk Is Required for BCR-mediated Activation of p90Rsk, but Not p70S6k, via a Mitogen-activated Protein Kinase-independent Pathway in B Cells
J. Biol. Chem., July 18, 1997; 272(29): 18200 - 18208.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. J. Kim, Y.-T. Kim, and S. Pillai
Association of Activated Phosphatidylinositol 3-Kinase with p120[IMAGE] in Antigen Receptor-ligated B Cells
J. Biol. Chem., November 27, 1995; 270(46): 27504 - 27509.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1995 by The American Association of Immunologists, Inc. All rights reserved.