| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 154, Issue 7 3118-3127, Copyright © 1995 by American Association of Immunologists
ARTICLES |
DC Cronin 2nd, R Stack and FW Fitch
Committee on Immunology, University of Chicago, IL 60637.
Interactions between CD4+ T cells and B cells are mediated by both soluble factors and cell surface molecules. The Ag-independent interaction between the CD40 ligand, expressed on activated T cells, and its CD40 receptor, expressed on B cells, enhances B cell proliferation in response to IL-4 stimulation. The expression of the CD40 ligand is induced on CD4+ T cells by stimulation with Ag-pulsed APC or mitogens. Here, we show that at least some IL-4-producing murine CD8+ T cell clones can be induced to express the CD40 ligand when stimulated with anti-CD3 mAb. Additionally, such activated CD8+ IL-4- producing clones potentiate the proliferative response of small resting B cells to IL-4 and induce Ig secretion by small resting B cells to IL- 4 and IL-5. Proliferation of small resting B cells cultured with IL-4 in the presence of activated IL-4-producing CD8+ murine T cell clones appeared to be mediated by the expression of the CD40 ligand on the T cell because an anti-CD40 ligand mAb inhibited this proliferative response. A conventional murine CD8+ CTL clone, which did not produce IL-4 or express CD40 ligand upon activation, did not potentiate proliferation of small resting B cells exposed to IL-4. Thus, under some circumstances, CD8+ T cells that are able to express CD40 ligand may be able to provide B cell help.
This article has been cited by other articles:
|
|
 |
|
  B. J. E. Raveney and D. J. Morgan Dynamic Control of Self-Specific CD8+ T Cell Responses via a Combination of Signals Mediated by Dendritic Cells J. Immunol., September 1, 2007; 179(5): 2870 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. H. Hernandez, L. Shen, and K. L. Rock CD40-CD40 Ligand Interaction between Dendritic Cells and CD8+ T Cells Is Needed to Stimulate Maximal T Cell Responses in the Absence of CD4+ T Cell Help J. Immunol., March 1, 2007; 178(5): 2844 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Riou, A. R Dumont, B. Yassine-Diab, E. K Haddad, and R.-P. Sekaly IL-4 influences the differentiation and the susceptibility to activation-induced cell death of human naive CD8+ T cells Int. Immunol., June 1, 2006; 18(6): 827 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kienzle, S. Olver, K. Buttigieg, P. Groves, M. L. Janas, A. Baz, and A. Kelso Progressive Differentiation and Commitment of CD8+ T Cells to a Poorly Cytolytic CD8low Phenotype in the Presence of IL-4 J. Immunol., February 15, 2005; 174(4): 2021 - 2029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Beacock-Sharp, A. M. Donachie, N. C. Robson, and A. M. Mowat A role for dendritic cells in the priming of antigen-specific CD4+ and CD8+ T lymphocytes by immune-stimulating complexes in vivo Int. Immunol., June 1, 2003; 15(6): 711 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kienzle, K. Buttigieg, P. Groves, T. Kawula, and A. Kelso A Clonal Culture System Demonstrates That IL-4 Induces a Subpopulation of Noncytolytic T Cells with Low CD8, Perforin, and Granzyme Expression J. Immunol., February 15, 2002; 168(4): 1672 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Mintern, G. M. Davey, G. T. Belz, F. R. Carbone, and W. R. Heath Cutting Edge: Precursor Frequency Affects the Helper Dependence of Cytotoxic T Cells J. Immunol., February 1, 2002; 168(3): 977 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Green, R. J. Noelle, B. G. Durell, and W. R. Green Characterization of the CD154-Positive and CD40-Positive Cellular Subsets Required for Pathogenesis in Retrovirus-Induced Murine Immunodeficiency J. Virol., April 15, 2001; 75(8): 3581 - 3589. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Stanciu, K. Roberts, L. C. K. Lau, A. J. Coyle, and S. L. Johnston Induction of type 2 activity in adult human CD8+ T cells by repeated stimulation and IL-4 Int. Immunol., March 1, 2001; 13(3): 341 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Gorbachev, P. S. Heeger, and R. L. Fairchild CD4+ and CD8+ T Cell Priming for Contact Hypersensitivity Occurs Independently of CD40-CD154 Interactions J. Immunol., February 15, 2001; 166(4): 2323 - 2332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vizler, N. Bercovici, A. Heurtier, N. Pardigon, K. Goude, K. Bailly, C. Combadiere, and R. S. Liblau Relative Diabetogenic Properties of Islet-Specific Tc1 and Tc2 Cells in Immunocompetent Hosts J. Immunol., December 1, 2000; 165(11): 6314 - 6321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Barnhart, P. A. Kosinski, Z. Wang, G. S. Ford, M. Kiledjian, and L. R. Covey Identification of a Complex that Binds to the CD154 3' Untranslated Region: Implications for a Role in Message Stability During T Cell Activation J. Immunol., October 15, 2000; 165(8): 4478 - 4486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Furukawa, H. Sasaki, R. B. Pollard, and F. Suzuki Lanoconazole, a new imidazole antimycotic compound, protects MAIDS mice against encephalitis caused by Cryptococcus neoformans J. Antimicrob. Chemother., September 1, 2000; 46(3): 443 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delgado and D. Ganea Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit T Cell-Mediated Cytotoxicity by Inhibiting Fas Ligand Expression J. Immunol., July 1, 2000; 165(1): 114 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Sha and R. W. Compans Induction of CD4+ T-Cell-Independent Immunoglobulin Responses by Inactivated Influenza Virus J. Virol., June 1, 2000; 74(11): 4999 - 5005. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Vukmanovic-Stejic, B. Vyas, P. Gorak-Stolinska, A. Noble, and D. M. Kemeny Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes Blood, January 1, 2000; 95(1): 231 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodolfo, C. Zilocchi, P. Accornero, B. Cappetti, I. Arioli, and M. P. Colombo IL-4-Transduced Tumor Cell Vaccine Induces Immunoregulatory Type 2 CD8 T Lymphocytes That Cure Lung Metastases Upon Adoptive Transfer J. Immunol., August 15, 1999; 163(4): 1923 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Erard, J. A. Garcia-Sanz, R. Moriggl, and M.-T. Wild Presence or Absence of TGF-{beta} Determines IL-4-Induced Generation of Type 1 or Type 2 CD8 T Cell Subsets J. Immunol., January 1, 1999; 162(1): 209 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. G. Wagner, P. J. Kurtin, A. Wahner, M. Brackertz, D. J. Berry, J. J. Goronzy, and C. M. Weyand The Role of CD8+ CD40L+ T Cells in the Formation of Germinal Centers in Rheumatoid Synovitis J. Immunol., December 1, 1998; 161(11): 6390 - 6397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Thomsen, A. Nansen, J. P. Christensen, S. O. Andreasen, and O. Marker CD40 Ligand Is Pivotal to Efficient Control of Virus Replication in Mice Infected with Lymphocytic Choriomeningitis Virus J. Immunol., November 1, 1998; 161(9): 4583 - 4590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cerwenka, L. L. Carter, J. B. Reome, S. L. Swain, and R. W. Dutton In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines J. Immunol., July 1, 1998; 161(1): 97 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Nazaruk, R. Rochford, M. V. Hobbs, and M. J. Cannon Functional Diversity of the CD8+ T-Cell Response to Epstein-Barr Virus (EBV): Implications for the Pathogenesis of EBV-Associated Lymphoproliferative Disorders Blood, May 15, 1998; 91(10): 3875 - 3883. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
